Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells

Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2

(2017) Lili Tian et al.   Cell Death & Disease

CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer

(2017) Xinfeng Yu et al.   Scientific Reports

Antitumour activity of the novel flavonoid Oncamex in preclinical breast cancer models

(2016) Carlos Martínez-Pérez et al.   BRITISH JOURNAL OF CANCER

Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression

(2016) Ons Zakraoui et al.   MOLECULAR CARCINOGENESIS

Resveratrol inhibits IL-6-induced ovarian cancer cell migration through epigenetic up-regulation of autophagy

(2016) Alessandra Ferraresi et al.   MOLECULAR CARCINOGENESIS

Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines

(2016) Esther P. Jane et al.   MOLECULAR CARCINOGENESIS

Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes

(2016) Inhae Kang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Genistein and delphinidin antagonize the genotoxic effects of the mycotoxin alternariol in human colon carcinoma cells

(2016) Georg Aichinger et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

(2016) Francisco A. Tomás-Barberán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pomegranate extract prevents skeletal muscle of mice against wasting induced by acute TNF-α injection

(2016) Julie Rodriguez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary agents for prevention and treatment of lung cancer

(2015) Naghma Khan et al.   CANCER LETTERS

Dietary Polyphenols in Prevention and Treatment of Prostate Cancer

(2015) Rahul Lall et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

(2015) Massimo Fantini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preparative isolation and purification of urolithins from the intestinal metabolites of pomegranate ellagitannins by high-speed counter-current chromatography

(2015) Wenhua Zhao et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction ofCDKN1A(p21) as a common mechanism involved

(2015) Antonio González-Sarrías et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages

(2015) Jakub P. Piwowarski et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway

(2015) Ly Quoc Trung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells

(2015) Hyunnho Cho et al.   Food & Function

The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells

(2015) Antonio González-Sarrías et al.   Food & Function

In Vitro Bioaccessibility, Human Gut Microbiota Metabolites and Hepatoprotective Potential of Chebulic Ellagitannins: A Case of Padma Hepaten® Formulation

(2015) Daniil Olennikov et al.   Nutrients

Autophagy-based survival prognosis in human colorectal carcinoma

(2015) Maopeng Yang et al.   Oncotarget

Involvement of autophagy induction in penta-1,2,3,4,6-O-galloyl-β-D-glucose-induced senescence-like growth arrest in human cancer cells

(2014) Yinhui Dong et al.   Autophagy

Cecal Succinate Elevated by Some Dietary Polyphenols May Inhibit Colon Cancer Cell Proliferation and Angiogenesis

(2014) Tomoaki Haraguchi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Apoptosis Inducing Effects of Kuding Tea Polyphenols in Human Buccal Squamous Cell Carcinoma Cell Line BcaCD885

(2014) Xin Zhao et al.   Nutrients

Cytoprotective and nonprotective autophagy in cancer therapy

(2013) David A. Gewirtz   Autophagy

In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells

(2013) Zhenpeng Qiu et al.   FOOD AND CHEMICAL TOXICOLOGY

Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways

(2013) Sudeshna Mukherjee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration

(2012) Chiao-Chun Liao et al.   Autophagy

Ellagic Acid and Polyhydroxylated Urolithins Are Potent Catalytic Inhibitors of Human Topoisomerase II: An in Vitro Study

(2012) Valentina Furlanetto et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases

(2011) V. S. Thakur et al.   CARCINOGENESIS

Urolithins, ellagitannin metabolites produced by colon microbiota, inhibit Quorum Sensing in Yersinia enterocolitica: Phenotypic response and associated molecular changes

(2011) J.A. Giménez-Bastida et al.   FOOD CHEMISTRY

Ellagitannins, ellagic acid and their derived metabolites: A review about source, metabolism, functions and health

(2011) J.M. Landete   FOOD RESEARCH INTERNATIONAL

Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells

(2011) Suboj Babykutty et al.   MOLECULAR CARCINOGENESIS

Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment

(2010) Giuseppe Filomeni et al.   Autophagy

Pomegranate Ellagitannin-Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro

(2010) L. S. Adams et al.   Cancer Prevention Research

Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins

(2010) Sashi G. Kasimsetty et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cardiac specific deletion ofN-methyl-d-aspartate receptor 1 ameliorates mtMMP-9 mediated autophagy/mitophagy in hyperhomocysteinemia

(2010) Neetu Tyagi et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

MMP-9 (Gelatinase B) Expression is Associated With Disease-Free Survival and Disease-Specific Survival in Colorectal Cancer Patients

(2009) Riyad Bendardaf et al.   CANCER INVESTIGATION

Effects of Pomegranate Chemical Constituents/Intestinal Microbial Metabolites on CYP1B1 in 22Rv1 Prostate Cancer Cells

(2009) Sashi G. Kasimsetty et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay

(2009) Dobroslawa Bialonska et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism☆

(2009) Mar Larrosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins

(2009) Antonio González-Sarrías et al.   MOLECULAR NUTRITION & FOOD RESEARCH