Statins: Could an old friend help in the fight against COVID‐19?

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Statin Use and the Risk of Subsequent Hospitalized Exacerbations in COPD Patients with Frequent Exacerbations

(2020) Chieh-Mo Lin et al.   International Journal of Chronic Obstructive Pulmonary Disease

NLRP3 Inflammasome—A Key Player in Antiviral Responses

(2020) Chunyuan Zhao et al.   Frontiers in Immunology

COVID-19, ACE2, and the cardiovascular consequences

(2020) Andrew M. South et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19

(2020) Peng Zhang et al.   CIRCULATION RESEARCH

COVID-19 treatment by repurposing drugs until the vaccine is in sight

(2020) Mrudula Phadke et al.   DRUG DEVELOPMENT RESEARCH

Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis

(2020) Wei-jie Guan et al.   EUROPEAN RESPIRATORY JOURNAL

A Review of Coronavirus Disease-2019 (COVID-19)

(2020) Tanu Singhal   INDIAN JOURNAL OF PEDIATRICS

Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19

(2020) Ishan Paranjpe et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up

(2020) Behnood Bikdeli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease

(2020) Majd AlGhatrif et al.   JAMA Cardiology

Clotting Factors in COVID-19: Epidemiological Association and Prognostic Values in Different Clinical Presentations in an Italian Cohort

(2020) Pierpaolo Di Micco et al.   Journal of Clinical Medicine

Statin therapy in COVID-19 infection

(2020) Vincenzo Castiglione et al.   European Heart Journal-Cardiovascular Pharmacotherapy

Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past

(2020) Dimitrios Giannis et al.   JOURNAL OF CLINICAL VIROLOGY

Statins in coronavirus outbreak: It’s time for experimental and clinical studies

(2020) Maurizio Bifulco et al.   PHARMACOLOGICAL RESEARCH

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 inflammasome as a treatment target in atherosclerosis: A focus on statin therapy

(2019) Negin Parsamanesh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulatory effects of statins on the autophagy: A therapeutic perspective

(2019) Milad Ashrafizadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Current perspectives on statins as potential anti-cancer therapeutics: clinical outcomes and underlying molecular mechanisms

(2019) Ali Fatehi Hassanabad   Translational Lung Cancer Research

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

(2019) Nils C. Gassen et al.   Nature Communications

Statins in the treatment of COPD and asthma — where do we stand?

(2018) Jennifer Y So et al.   CURRENT OPINION IN PHARMACOLOGY

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

Simvastatin Suppresses Interleukin Iβ Release in Human Peripheral Blood Mononuclear Cells Stimulated With Cholesterol Crystals

(2018) Anna J. Boland et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Autophagy during viral infection — a double-edged sword

(2018) Younho Choi et al.   NATURE REVIEWS MICROBIOLOGY

Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing

(2018) Punya Shrivastava-Ranjan et al.   mBio

CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells

(2018) Adam L. Vanarsdall et al.   mBio

Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation

(2018) Tao-Tao Tang et al.   Cell Death & Disease

Effects of Pravastatin on Type 1 Diabetic Rat Heart with or without Blood Glycemic Control

(2018) Jeong Jin Min et al.   Journal of Diabetes Research

Targeting host lipid flows: Exploring new antiviral and antibiotic strategies

(2018) Alberto Fernández-Oliva et al.   CELLULAR MICROBIOLOGY

The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells

(2018) Isabella Spinello et al.   HAEMATOLOGICA

The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock

(2017) Xiaoli Chen et al.   MEDIATORS OF INFLAMMATION

Downregulation of monocytic differentiation via modulation of CD147 by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

(2017) Manda V. Sasidhar et al.   PLoS One

Inhibition of CD147 (Cluster of Differentiation 147) Ameliorates Acute Ischemic Stroke in Mice by Reducing Thromboinflammation

(2017) Rong Jin et al.   STROKE

Rho-kinase inhibitor treatment prevents pulmonary inflammation and coagulation in lipopolysaccharide-induced lung injury

(2017) Renyu Ding et al.   THROMBOSIS RESEARCH

Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses

(2017) Shringkhala Bajimaya et al.   VIROLOGY

The Interaction between Nidovirales and Autophagy Components

(2017) Yingying Cong et al.   Viruses-Basel

Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

(2017) Sin-Ting Wang et al.   Cell Death & Disease

Atorvastatin attenuates plaque vulnerability by downregulation of EMMPRIN expression via COX-2/PGE2 pathway

(2017) Xing Liang et al.   Experimental and Therapeutic Medicine

Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy

(2017) Zuozhang Yang et al.   EBioMedicine

Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes

(2016) Fanqi Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Autophagy in leukocytes and other cells: mechanisms, subsystem organization, selectivity, and links to innate immunity

(2016) Vojo Deretic   JOURNAL OF LEUKOCYTE BIOLOGY

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus

(2016) Che-Man Chan et al.   JOURNAL OF VIROLOGY

MTOR, PIK3C3, and autophagy: Signaling the beginning from the end

(2015) Michael J Munson et al.   Autophagy

How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity

(2015) G. D. Grass et al.   BIOSCIENCE REPORTS

NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins

(2015) Afrasyab Altaf et al.   CORONARY ARTERY DISEASE

Association between statin use and plasma D-dimer levels

(2015) Dimitri Mikhailidis et al.   THROMBOSIS AND HAEMOSTASIS

Viruses and the autophagy pathway

(2015) William T. Jackson   VIROLOGY

Statins May Decrease the Fatality Rate of Middle East Respiratory Syndrome Infection: FIG 1 

(2015) Shu Yuan   mBio

CD147 modulates autophagy through the PI3K/Akt/mTOR pathway in human prostate cancer PC-3 cells

(2015) FANG FANG et al.   Oncology Letters

Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation

(2015) Jonathan Vosper et al.   Oncotarget

Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome

(2015) Gonzalo J. Martínez et al.   Journal of the American Heart Association

Multiple roles of the coagulation protease cascade during virus infection

(2014) S. Antoniak et al.   BLOOD

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

(2014) Lijuan Xiong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Action and Efficacy of Statins against Influenza

(2014) Parvaneh Mehrbod et al.   Biomed Research International

Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes

(2013) Yu-Miao Wei et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

NLRP3 inflammasome activation in coronary artery disease: results from prospective and randomized study of treatment with atorvastatin or rosuvastatin

(2013) Mamoru Satoh et al.   CLINICAL SCIENCE

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Autophagosome formation—The role of ULK1 and Beclin1–PI3KC3 complexes in setting the stage

(2013) Martina Wirth et al.   SEMINARS IN CANCER BIOLOGY

Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication

(2012) Ming-Xia Sun et al.   Autophagy

The effect of rosuvastatin on incident pneumonia: results from the JUPITER trial

(2012) V. Novack et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Statins, autophagy and cancer metastasis

(2012) Jing Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Differential Effects of Lovastatin on Cisplatin Responses in Normal Human Mesothelial Cells versus Cancer Cells: Implication for Therapy

(2012) Yandong Shi et al.   PLoS One

Involvement of Autophagy in Coronavirus Replication

(2012) Helena Maier et al.   Viruses-Basel

Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

(2012) Juan Reguera et al.   PLoS Pathogens

Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage

(2011) Zacharie Taoufiq et al.   MALARIA JOURNAL

Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum

(2011) Cécile Crosnier et al.   NATURE

EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD

(2011) STEPHANE JOUNEAU et al.   RESPIROLOGY

Multifaceted roles for lipids in viral infection

(2011) Nicholas S. Heaton et al.   TRENDS IN MICROBIOLOGY

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

(2010) Anthony Orvedahl et al.   Cell Host & Microbe

Statins Inhibit Angiotensin II/Smad Pathway and Related Vascular Fibrosis, by a TGF-β-Independent Process

(2010) Raúl Rodrigues Díez et al.   PLoS One

Do viruses subvert cholesterol homeostasis to induce host cubic membranes?

(2010) Yuru Deng et al.   TRENDS IN CELL BIOLOGY

Tissue Factor in Coagulation

(2009) Saulius Butenas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Statins and Cardiovascular Diseases: From Cholesterol Lowering to Pleiotropy

(2009) Qian Zhou et al.   CURRENT PHARMACEUTICAL DESIGN

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Results of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial by Stroke Subtypes

(2009) Pierre Amarenco et al.   STROKE

Overexpression of ACE2 Enhances Plaque Stability in a Rabbit Model of Atherosclerosis

(2008) Bo Dong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Statins inhibit Rho kinase activity in patients with atherosclerosis

(2008) Anju Nohria et al.   ATHEROSCLEROSIS

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2

(2008) Joerg Glende et al.   VIROLOGY