Cytokines and costimulation in acute graft-versus-host disease

Monitoring TIGIT/DNAM-1 and PVR/PVRL2 immune checkpoint's expression levels in allogeneic stem cell transplantation for acute myeloid leukemia

(2019) Norimichi Hattori et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

(2019) Agnieszka Czechowicz et al.   Nature Communications

Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker parameters in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study

(2019) Sudha Visvanathan et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation

(2019) Wenjun Ouyang et al.   IMMUNITY

The Immunobiology of the Interleukin-12 Family: Room for Discovery

(2019) Elia D. Tait Wojno et al.   IMMUNITY

Targeting Interleukin-6 Signaling in Clinic

(2019) Sujin Kang et al.   IMMUNITY

Outcomes and Predictors of Response in Steroid-Refractory Acute Graft-versus-Host Disease

(2019) Armin Rashidi et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance

(2019) Benson M. George et al.   Cell Stem Cell

CTLA4Ig-based reduced intensity conditioning and donor lymphocyte infusions for haploidentical transplantation in refractory aggressive B-cell lymphoma relapsing after an autograft: Early results from a pilot study

(2019) Sarita Rani Jaiswal et al.   EXPERIMENTAL HEMATOLOGY

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

(2019) Motoko Koyama et al.   IMMUNITY

Structure and Functional Binding Epitope of V-domain Ig Suppressor of T Cell Activation

(2019) Nishant Mehta et al.   Cell Reports

Idarubicin, cytarabine, and nivolumab in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a single-arm, phase 2 study

(2019) Farhad Ravandi et al.   Lancet Haematology

VISTA is an acidic pH-selective ligand for PSGL-1

(2019) Robert J. Johnston et al.   NATURE

Interleukin-10 mediated immune regulation after stem cell transplantation: Mechanisms and implications for therapeutic intervention

(2019) Ping Zhang et al.   SEMINARS IN IMMUNOLOGY

IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling

(2019) Andrew N. Wilkinson et al.   BLOOD

Signaling and Function of Interleukin-2 in T Lymphocytes

(2018) Sarah H. Ross et al.   Annual Review of Immunology

Strategies to activate NK cells to prevent relapse and induce remission following hematopoietic stem cell transplantation

(2018) Sarah Cooley et al.   BLOOD

Recommendations for managing PD-1 blockade in the context of allogeneic HCT in Hodgkin lymphoma: taming a necessary evil

(2018) Charles Herbaux et al.   BLOOD

CD8 + T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in acute myeloid leukemia (AML) patients

(2018) Mengjie Wang et al.   CLINICAL IMMUNOLOGY

Tocilizumab, tacrolimus and methotrexate for the prevention of acute graft- versus -host disease: low incidence of lower gastrointestinal tract disease

(2018) William R. Drobyski et al.   HAEMATOLOGICA

Recipient mucosal-associated invariant T cells control GVHD within the colon

(2018) Antiopi Varelias et al.   JOURNAL OF CLINICAL INVESTIGATION

OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms

(2018) Xiaolong Zhang et al.   Cell Reports

Tocilizumab, tacrolimus and methotrexate for the prevention of acute graft- versus -host disease: low incidence of lower gastrointestinal tract disease

(2018) William R. Drobyski et al.   HAEMATOLOGICA

Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis

(2018) Laurence E. Cheng et al.   Arthritis & Rheumatology

Significant Risk of Graft-versus-Host Disease with Exposure to Checkpoint Inhibitors Before and After Allogeneic transplantation

(2018) Awais Ijaz et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

VSIG-3 as a ligand of VISTA inhibits human T cell function

(2018) Jinghua Wang et al.   IMMUNOLOGY

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease

(2018) Dongchang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates

(2018) Benjamin K. Watkins et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond

(2018) Jodi L. Karnell et al.   ADVANCED DRUG DELIVERY REVIEWS

IL-2 promotes early Treg reconstitution after allogeneic hematopoietic cell transplantation

(2017) Brian C. Betts et al.   HAEMATOLOGICA

In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation

(2017) Joseph Pidala et al.   HAEMATOLOGICA

Alarmins and immunity

(2017) De Yang et al.   IMMUNOLOGICAL REVIEWS

TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy

(2017) William C. Dougall et al.   IMMUNOLOGICAL REVIEWS

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

(2017) Jooho Chung et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: Results from the phase III, double-blinded, placebo- and active comparator–controlled VOYAGE 1 trial

(2017) Andrew Blauvelt et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity

(2017) K A Kuhn et al.   Mucosal Immunology

VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

(2017) Jianjun Gao et al.   NATURE MEDICINE

Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

(2017) Julius C. Fischer et al.   Science Translational Medicine

Combined OX40L and mTOR blockade controls effector T cell activation while preserving T reg reconstitution after transplant

(2017) Victor Tkachev et al.   Science Translational Medicine

IL-2 promotes early Treg reconstitution after allogeneic hematopoietic cell transplantation

(2017) Brian C. Betts et al.   HAEMATOLOGICA

In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation

(2017) Joseph Pidala et al.   HAEMATOLOGICA

Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double-Blind, Active Comparator- and Placebo-Controlled Study

(2017) Francisco J. Blanco et al.   Arthritis & Rheumatology

Natural Killer Cells in Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation

(2017) Federico Simonetta et al.   Frontiers in Immunology

The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases

(2017) Brad Griesenauer et al.   Frontiers in Immunology

Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study

(2016) Jürgen Braun et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of Cumulative Steroid Dose with Risk of Infection after Treatment for Severe Acute Graft-versus-Host Disease

(2016) Yayoi Matsumura-Kimoto et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Combination Therapy for Graft-versus-Host Disease Prophylaxis with Etanercept and Extracorporeal Photopheresis: Results of a Phase II Clinical Trial

(2016) Carrie L. Kitko et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression

(2016) L. Belle et al.   BLOOD

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

(2016) Scott N. Furlan et al.   BLOOD

Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD

(2016) B. M. Matta et al.   BLOOD

Co-stimulatory and Co-inhibitory Pathways in Autoimmunity

(2016) Qianxia Zhang et al.   IMMUNITY

The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses

(2016) Lindsay K. Ward-Kavanagh et al.   IMMUNITY

First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28

(2016) Nicolas Poirier et al.   JOURNAL OF IMMUNOLOGY

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

(2016) Rahul Palchaudhuri et al.   NATURE BIOTECHNOLOGY

Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy

(2016) Akanksha Chhabra et al.   Science Translational Medicine

Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease

(2016) Minoru Kanaya et al.   PLoS One

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

(2015) D. K. Reichenbach et al.   BLOOD

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation

(2015) A. Varelias et al.   BLOOD

Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects

(2015) K. H. Gartlan et al.   BLOOD

 -Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice

(2015) H. Uryu et al.   BLOOD

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Out-of-Sequence Signal 3 Paralyzes Primary CD4+ T-Cell-Dependent Immunity

(2015) Gail D. Sckisel et al.   IMMUNITY

Donor colonic CD103+dendritic cells determine the severity of acute graft-versus-host disease

(2015) Motoko Koyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Donor interleukin-22 and host type I interferon signaling pathway participate in intestinal graft-versus-host disease via STAT1 activation and CXCL10

(2015) B Lamarthée et al.   Mucosal Immunology

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses

(2015) Claudia Baumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

(2015) Jilu Zhang et al.   Science Translational Medicine

Ultra Low-Dose IL-2 for GVHD Prophylaxis after Allogeneic Hematopoietic Stem Cell Transplantation Mediates Expansion of Regulatory T Cells without Diminishing Antiviral and Antileukemic Activity

(2014) A. A. Kennedy-Nasser et al.   CLINICAL CANCER RESEARCH

CSF-1–dependant donor-derived macrophages mediate chronic graft-versus-host disease

(2014) Kylie A. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

ICOS Controls the Pool Size of Effector-Memory and Regulatory T Cells

(2014) Y. Burmeister et al.   JOURNAL OF IMMUNOLOGY

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial

(2014) Glen A Kennedy et al.   LANCET ONCOLOGY

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vivo T Cell Costimulation Blockade with Abatacept for Acute Graft-versus-Host Disease Prevention: A First-in-Disease Trial

(2013) Divya T. Koura et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Promoting regulation via the inhibition of DNAM-1 after transplantation

(2013) M. Koyama et al.   BLOOD

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

(2013) Dietmar M.W. Zaiss et al.   IMMUNITY

Blockade of individual Notch ligands and receptors controls graft-versus-host disease

(2013) Ivy T. Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphatidylinositol 3-Kinase-Independent Signaling Pathways Contribute to ICOS-Mediated T Cell Costimulation in Acute Graft-Versus-Host Disease in Mice

(2013) J. Li et al.   JOURNAL OF IMMUNOLOGY

A Diametric Role for OX40 in the Response of Effector/Memory CD4+ T Cells and Regulatory T Cells to Alloantigen

(2013) G. Kinnear et al.   JOURNAL OF IMMUNOLOGY

IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effect

(2013) M Couturier et al.   LEUKEMIA

ST2 as a Marker for Risk of Therapy-Resistant Graft-versus-Host Disease and Death

(2013) Mark T. Vander Lugt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

(2013) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF-Inhibition with Etanercept for Graft-versus-Host Disease Prevention in High-Risk HCT: Lower TNFR1 Levels Correlate with Better Outcomes

(2012) Sung W. Choi et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Dead on Arrival: Understanding the Failure of CTLA4-Immunoglobulin Therapy in Inflammatory Bowel Disease

(2012) Lloyd Mayer et al.   GASTROENTEROLOGY

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

Selective Blockade of Herpesvirus Entry Mediator-B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction

(2012) M.-L. del Rio et al.   JOURNAL OF IMMUNOLOGY

The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

(2012) W. V. Bonilla et al.   SCIENCE

Roles of CD28, CTLA4, and Inducible Costimulator in Acute Graft-versus-Host Disease in Mice

(2011) Jun Li et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR t in mice

(2011) Y. Yu et al.   BLOOD

Durable donor engraftment after radioimmunotherapy using  -emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation

(2011) Y. Chen et al.   BLOOD

Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway

(2011) Y. Sakoda et al.   BLOOD

Type I-IFNs control GVHD and GVL responses after transplantation

(2011) R. J. Robb et al.   BLOOD

Vstm3 is a member of the CD28 family and an important modulator of T-cell function

(2011) Steven D. Levin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

(2011) Li Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses

(2010) R. Das et al.   BLOOD

GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

(2010) W. P. Miller et al.   BLOOD

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease

(2010) Y. Zhang et al.   BLOOD

Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation

(2010) I. Tawara et al.   CLINICAL CANCER RESEARCH

Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice

(2010) Shoji Asakura et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression

(2010) Jörn C. Albring et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice

(2010) T. Nabekura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network

(2009) A. M. Alousi et al.   BLOOD

Acute graft-versus-host disease: from the bench to the bedside

(2009) G. Socie et al.   BLOOD

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease

(2009) X. Chen et al.   BLOOD

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

(2008) P. A. Taylor et al.   BLOOD

IL-17 contributes to CD4-mediated graft-versus-host disease

(2008) L. W. Kappel et al.   BLOOD