Donor interleukin-22 and host type I interferon signaling pathway participate in intestinal graft-versus-host disease via STAT1 activation and CXCL10

Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD

(2014) C. M. Capitini et al.   BLOOD

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

(2014) S. Spoerl et al.   BLOOD

Neutrophils Recruited by IL-22 in Peripheral Tissues Function as TRAIL-Dependent Antiviral Effectors against MCMV

(2014) Maria A. Stacey et al.   Cell Host & Microbe

CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis

(2014) Yaniv Zohar et al.   JOURNAL OF CLINICAL INVESTIGATION

A New Approach to the Blocking of Alloreactive T Cell-Mediated Graft-versus-Host Disease by In Vivo Administration of Anti-CXCR3 Neutralizing Antibody

(2014) S. He et al.   JOURNAL OF IMMUNOLOGY

Interleukin-22 Aggravates Murine Acute Graft-Versus-Host Disease by Expanding Effector T Cell and Reducing Regulatory T Cell

(2014) Kai Zhao et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells

(2014) L L Korn et al.   Mucosal Immunology

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

(2014) Lukas Schwab et al.   NATURE MEDICINE

The identification and characteristics of IL-22-producing T cells in acute graft-versus-host disease following allogeneic bone marrow transplantation

(2013) Kai Zhao et al.   IMMUNOBIOLOGY

IL-22, not simply a Th17 cytokine

(2013) Sascha Rutz et al.   IMMUNOLOGICAL REVIEWS

IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effect

(2013) M Couturier et al.   LEUKEMIA

Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?

(2013) Heiko Mühl   Frontiers in Immunology

IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets

(2012) Malte Bachmann et al.   BIOCHEMICAL PHARMACOLOGY

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

Plasmacytoid dendritic cells and Th17 immune response contribution in gastrointestinal acute graft-versus-host disease

(2012) C Bossard et al.   LEUKEMIA

Type I-IFNs control GVHD and GVL responses after transplantation

(2011) R. J. Robb et al.   BLOOD

Recent advances in IL-22 biology

(2011) L. A. Zenewicz et al.   INTERNATIONAL IMMUNOLOGY

Long-Term Survival and Late Deaths After Allogeneic Hematopoietic Cell Transplantation

(2011) John R. Wingard et al.   JOURNAL OF CLINICAL ONCOLOGY

Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology

(2011) Masahito Kamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A

(2010) Gregory F. Sonnenberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22 Induces an Acute-Phase Response

(2010) S. C. Liang et al.   JOURNAL OF IMMUNOLOGY

Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa

(2009) M. M. Imanguli et al.   BLOOD

Interleukin (IL)-23 mediatesToxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

(2009) Melba Muñoz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY