Journal
BLOOD
Volume 125, Issue 19, Pages 3014-3023Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2014-12-615781
Keywords
-
Categories
Funding
- Japan Society for the Promotion of Science, KAKENHI [26461438, 25293217]
- Promotion and Standardization of the Tenure-Track System
- Health and Labor Science Research grants
- Uehara Memorial Foundation
- North Japan Hematology Study Group
- Grants-in-Aid for Scientific Research [15K15365, 26461438, 25293217] Funding Source: KAKEN
Ask authors/readers for more resources
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy for various hematopoietic disorders. Graft-versus-host disease (GVHD) and infections are the major obstacles of HSCT, and their close relationship has been suggested. Although roles of bacterial and viral infections in the pathophysiology of GVHD are well described, impacts of fungal infection on GVHD remain to be elucidated. In mouse models of GVHD, injection of a-mannan (Mn), a major component of fungal cell wall, or heat-killed Candida albicans exacerbated GVHD, particularly in the lung. Mn-induced donor T-cell polarization toward Th17 and lung-specific chemokine environment in GVHD led to accumulation of Th17 cells in the lung. The detrimental effects of Mn on GVHD depended on donor IL-17A production and host C-type lectin receptor Dectin-2. These results suggest a previously unrecognized link between pulmonary GVHD and fungal infection after allogeneic HSCT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available