Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates

Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

(2020) Dominic M Walsh et al.   CURRENT OPINION IN NEUROBIOLOGY

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis

(2020) Arun Thiruvalluvan et al.   MOLECULAR CELL

Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine

(2019) Amber N. Ziegler et al.   Stem Cell Reports

Pathogenesis of SCA3 and implications for other polyglutamine diseases

(2019) Hayley S. McLoughlin et al.   NEUROBIOLOGY OF DISEASE

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Exosome isolation from distinct biofluids using precipitation and column-based approaches

(2018) Tânia Soares Martins et al.   PLoS One

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Insulin-like Growth Factor II Targets the mTOR Pathway to Reverse Autism-like Phenotypes in Mice

(2017) Adam B. Steinmetz et al.   JOURNAL OF NEUROSCIENCE

Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway

(2017) Katarina Trajkovic et al.   JOURNAL OF NEUROSCIENCE

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

(2017) Ilija Melentijevic et al.   NATURE

ER stress and the unfolded protein response in neurodegeneration

(2017) Claudio Hetz et al.   Nature Reviews Neurology

Human-to-mouse prion-like propagation of mutant huntingtin protein

(2016) Iksoo Jeon et al.   ACTA NEUROPATHOLOGICA

The unfolded protein response: mechanisms and therapy of neurodegeneration

(2016) Heather L. Smith et al.   BRAIN

The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?

(2016) Paula Garcia-Huerta et al.   BRAIN RESEARCH

Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture

(2016) Xuan Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Insulin-Like Growth Factor 2 - The Oncogene and its Accomplices

(2016) Sonja Kessler et al.   CURRENT PHARMACEUTICAL DESIGN

Disease modelling using human iPSCs

(2016) Stormy J. Chamberlain   HUMAN MOLECULAR GENETICS

Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes

(2016) T. Zhao et al.   JOURNAL OF NEUROSCIENCE

Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA

(2016) Paul J. Kemp et al.   JOURNAL OF PHYSIOLOGY-LONDON

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS

(2016) Ilary Allodi et al.   Scientific Reports

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

(2016) Lars Plate et al.   eLife

Insulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Decline in Huntington’s Disease

(2016) Linda Salem et al.   PLoS One

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

(2015) Wiep Scheper et al.   ACTA NEUROPATHOLOGICA

A user-friendly workflow for analysis of Illumina gene expression bead array data available at the arrayanalysis.org portal

(2015) Lars M.T. Eijssen et al.   BMC GENOMICS

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

(2015) Mauricio Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients

(2015) Edward J. Wild et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

(2015) Bibiana K.Y. Wong et al.   NEUROBIOLOGY OF DISEASE

Transcellular spreading of huntingtin aggregates in theDrosophilabrain

(2015) Daniel T. Babcock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies

(2015) Eugenia R. Zanella et al.   Science Translational Medicine

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

(2015) S. R. Ferrón et al.   Nature Communications

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1

(2014) Lisa M. Ryno et al.   ACS Chemical Biology

Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice

(2014) M. Pascual-Lucas et al.   EMBO Molecular Medicine

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

(2014) Eline Pecho-Vrieseling et al.   NATURE NEUROSCIENCE

IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice

(2014) Tiffany J. Mellott et al.   PLoS One

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

(2014) P. Valdes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin–proteasome system involvement in Huntington’s disease

(2014) Zaira Ortega et al.   Frontiers in Molecular Neuroscience

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans

(2013) M. Safra et al.   JOURNAL OF CELL SCIENCE

Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators

(2013) Hyeon-Sook Suh et al.   Journal of Neuroinflammation

Reduced Adult Hippocampal Neurogenesis and Working Memory Deficits in the Dgcr8-Deficient Mouse Model of 22q11.2 Deletion-Associated Schizophrenia Can Be Rescued by IGF2

(2013) Y. Ouchi et al.   JOURNAL OF NEUROSCIENCE

Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression

(2013) Catia C. Proenca et al.   PLoS One

Placental programming of anxiety in adulthood revealed by Igf2-null models

(2013) Mikael Allan Mikaelsson et al.   Nature Communications

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington’s disease

(2012) Amparo Zuleta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple roles for the actin cytoskeleton during regulated exocytosis

(2012) Natalie Porat-Shliom et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Insulin-Like Growth Factor 2 in Development and Disease: A Mini-Review

(2012) Daniel Bergman et al.   GERONTOLOGY

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

(2012) Rene L. Vidal et al.   HUMAN MOLECULAR GENETICS

I B Kinase/Nuclear Factor  B-Dependent Insulin-Like Growth Factor 2 (Igf2) Expression Regulates Synapse Formation and Spine Maturation via Igf2 Receptor Signaling

(2012) M. J. Schmeisser et al.   JOURNAL OF NEUROSCIENCE

Gene Expression Profiling of Neural Stem Cells and Their Neuronal Progeny Reveals IGF2 as a Regulator of Adult Hippocampal Neurogenesis

(2012) O. Bracko et al.   JOURNAL OF NEUROSCIENCE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

The Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B) Is Responsible for Tiam1 Binding and Rac1 Activation in Neuronal Cells

(2012) Daniel R. Henríquez et al.   PLoS One

Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2

(2012) Cristina M. Alberini et al.   TRENDS IN NEUROSCIENCES

Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntingtons Disease

(2011) R. Vidal et al.   CURRENT MOLECULAR MEDICINE

A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories

(2011) Roberto Carlos Agis-Balboa et al.   EMBO JOURNAL

A critical role for IGF-II in memory consolidation and enhancement

(2011) Dillon Y. Chen et al.   NATURE

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease

(2011) Philipp Koch et al.   NATURE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Insulin-like Growth Factor 2 Expression Modulates Taxol Resistance and Is a Candidate Biomarker for Reduced Disease-Free Survival in Ovarian Cancer

(2010) G. S. Huang et al.   CLINICAL CANCER RESEARCH

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

(2010) M. A. Pouladi et al.   HUMAN MOLECULAR GENETICS

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

High insulinlike growth factor I is associated with cognitive decline in Huntington disease

(2010) N. Saleh et al.   NEUROLOGY

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

(2010) S. Henis-Korenblit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Inhibition of the Insulin-like Growth Factor-1 Receptor (IGF1R) Tyrosine Kinase as a Novel Cancer Therapy Approach

(2009) Rongshi Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Decreased motoneuron survival in Igf2 null mice after sciatic nerve transection

(2009) Delia Silva et al.   NEUROREPORT

Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration

(2009) F. Cicchetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington’s disease: degradation of mutant huntingtin by autophagy

(2008) Sovan Sarkar et al.   FEBS Journal

Igf2r improves the survival and transmission ratio of Igf2 transgenic mice

(2008) Dimitrina D. Pravtcheva et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis

(2008) C. Hetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE