Article
Biochemistry & Molecular Biology
Bo Ren, Luanfeng Wang, Lin Shi, Xin Jin, Yan Liu, Rui Hai Liu, Fei Yin, Enrique Cadenas, Xiaoshuang Dai, Zhigang Liu, Xuebo Liu
Summary: Methionine restriction has shown protective effects against age-related cognitive decline in mice through preserving synaptic ultrastructure, increasing mitochondrial biogenesis, and reducing brain MDA levels. The role of FGF21 in this process is crucial.
Article
Oncology
Zhengxing Xie, Yan Zhuang, Zongqiang Zhang, Jieping Liu
Summary: This study investigated the prevalence and potential factors associated with cerebral microbleeds (CMBs) in patients with acromegaly. The results showed a higher incidence of CMBs in patients with acromegaly, which may be related to obstructive sleep apnea (OSA) caused by acromegaly. The increase in CMBs could be an important factor contributing to cognitive decline in patients with acromegaly.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Alexandra Horvath, Patrick Quinlan, Carl Eckerstrom, N. David Aberg, Anders Wallin, Johan Svensson
Summary: The study found that serum IGF-I was positively correlated with baseline MRI variables and annualized changes in hippocampal volume in sMCI patients, suggesting a neuroprotective effect of IGF-I in maintaining hippocampal volume. However, in AD patients, IGF-I was not associated with brain volumes, indicating a lack of neuroprotection in this disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Dinne Skjaerlund Christensen, Ellen Garde, Hartwig Roman Siebner, Erik Lykke Mortensen
Summary: This study found that there is an association between cognitive decline and perceived stress in midlife, with higher levels of stress leading to greater decline in cognitive ability.
Article
Geriatrics & Gerontology
Cassandra Morrison, Michael D. Oliver
Summary: This study aimed to examine whether healthy older adults with subjective cognitive decline (SCD+) have lower cognition and increased rates of cognitive decline compared to those without SCD (SCD-). The results showed that SCD+ individuals exhibited lower baseline cognition and steeper declines in global cognition, episodic memory, semantic memory, and perceptual speed compared to SCD-. There were no baseline differences in visuospatial ability and working memory between SCD+ and SCD-, but SCD+ individuals showed increased change over time in these two domains compared to SCD-.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Robin M. Voigt, Shohreh Raeisi, Jingyun Yang, Sue Leurgans, Christopher B. Forsyth, Aron S. Buchman, David A. Bennett, Ali Keshavarzian
Summary: The study did not find evidence supporting the hypothesis that intestinal barrier dysfunction precedes diagnosis of AD or MCI, changes in cognition, or brain pathology. Future research with larger sample sizes is needed for further investigation.
Article
Clinical Neurology
Naomi Vidal Ferreira, Natalia Gomes Goncalves, Claudia Szlejf, Alessandra C. Goulart, Itamar de Souza Santos, Bruce B. Duncan, Maria Ines Schmidt, Sandhi Maria Barreto, Paulo Caramelli, Natan Feter, Raphael Machado Castilhos, Luciano F. Drager, Paulo Lotufo, Isabela Bensenor, Claudia Kimie Suemoto
Summary: This study found that higher baseline scores on Life's Essential 8 (LE8), which includes sleep and other health factors, were associated with slower cognitive decline over an 8-year follow-up period. The association was mainly driven by health factors such as blood glucose and blood pressure. Age, sex, and race were also modifiers of this association.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Clinical Neurology
Jiao Wang, Ruixue Song, Abigail Dove, Xiuying Qi, Jun Ma, Erika J. Laukka, David A. Bennett, Weili Xu
Summary: The study found that low pulmonary function is associated with faster decline in overall cognition and different domain-specific cognitive functions, as well as differences in brain volumes.
ALZHEIMERS & DEMENTIA
(2022)
Article
Medicine, General & Internal
Hui-Fu Wang, Wei Zhang, Edmund T. Rolls, Yuzhu Li, Linbo Wang, Ya-Hui Ma, Jujiao Kang, Jianfeng Feng, Jin-Tai Yu, Wei Cheng
Summary: This study investigated the association of hearing performance with cognitive function, brain structure, and cerebrospinal fluid (CSF) proteins. The findings revealed that poor hearing performance was related to worse cognitive function, brain atrophy, and tau pathology.
Article
Neurosciences
Rong Zhou, Shan Wei, Yanyu Wang, Ling Gao, Liangjun Dang, Suhang Shang, Ningwei Hu, Wei Peng, Yi Zhao, Ye Yuan, Jingyi Wang, Jin Wang, Qiumin Qu
Summary: This study investigated the relationship between pulse pressure (PP) and cognitive decline in a community-based cohort. The results showed that elevated PP is associated with rapid cognitive decline, particularly in males, middle-aged individuals with low education, hypertension, and those who do not carry the APOE ε4 gene.
Article
Neurosciences
Benjamin Sweigart, Stacy L. Andersen, Anastasia Gurinovich, Stephanie Cosentino, Nicole Schupf, Thomas T. Perls, Paola Sebastiani
Summary: The study found that individuals carrying the APOE E2 allele had a slower rate of cognitive decline, indicating a protective effect against cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Siqi Li, Xuan Deng, Yumei Zhang
Summary: This study found a positive association between increasing values of the TyG index and the risk of cognitive decline. Monitoring the TyG index may help in the early identification of individuals at high risk of cognitive deterioration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Simone Migliore, Giulia D'Aurizio, Eugenia Scaricamazza, Sabrina Maffi, Consuelo Ceccarelli, Giovanni Ristori, Silvia Romano, Anna Castaldo, Mario Fichera, Giuseppe Curcio, Ferdinando Squitieri
Summary: This study focused on Cognitive Reserve (CR) in patients with early Huntington Disease (HD) and found that lifetime intellectual enrichment may influence clinical outcomes. The results indicated that leisure time cognitive reserve was inversely associated with functional impairment and HD progression, while positively associated with cognitive performance.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Ying Zhou, Wang Ran, Zhongyu Luo, Jianan Wang, Mengmeng Fang, Kai Wei, Jianzhong Sun, Min Lou
Summary: Animal experiments have shown the dependency of cerebrospinal fluid clearance function on age and sleep. However, human evidence is lacking. This study used dynamic magnetic resonance imaging to visualize the putative meningeal lymphatic and perineural pathways of cerebrospinal fluid clearance function and found a correlation between sleep quality and cognitive function.
Review
Clinical Neurology
Joaquim J. Ferreira, Filipe B. Rodrigues, Goncalo S. Duarte, Tiago A. Mestre, Anne-Catherine Bachoud-Levi, Anna Rita Bentivoglio, Jean-Marc Burgunder, Francisco Cardoso, Daniel O. Claassen, G. Bernard Landwehrmeyer, Jaime Kulisevsky, Melissa J. Nirenberg, Anne Rosser, Jan Roth, Klaus Seppi, Jaroslaw Slawek, Erin Furr-Stimming, Sarah J. Tabrizi, Francis O. Walker, Wim Vandenberghe, Joao Costa, Cristina Sampaio
Summary: The management of Huntington's disease (HD) is challenging and mainly consists of off-label treatments. A task force was commissioned to review available therapies for HD gene expansion carriers. Limited data supports the use of VMAT2 inhibitors for specific motor symptoms.
MOVEMENT DISORDERS
(2022)
Review
Clinical Neurology
Quang Tuan Remy Nguyen, Juan Dario Ortigoza Escobar, Jean-Marc Burgunder, Caterina Mariotti, Carsten Saft, Lena Elisabeth Hjermind, Katia Youssov, G. Bernhard Landwehrmeyer, Anne-Catherine Bachoud-Levi
Summary: This study examines the diagnosis of HD phenocopies and proposes guidance that combines the detection of clinical red flags with the classification of paraclinical testing options. The study utilizes a literature review and physician surveys to provide a diagnostic approach for HD phenocopies.
FRONTIERS IN NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Pablo Lemercier, Laurent Cleret de Langavant, Jennifer Hamet Bagnou, Katia Youssov, Laurie Lemoine, Etienne Audureau, Renaud Massart, Anne-Catherine Bachoud-Levi
Summary: Huntington's Disease (HD) is characterized by motor, cognitive, and behavioral symptoms that impact the quality of life of patients. The development of the Social Relationship Self-Questionnaire (SRSQ) provides insight into how HD patients perceive their social relationships and predicts future decline in motor, functional, and cognitive abilities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Rachid Riad, Marine Lunven, Hadrien Titeux, Xuan-Nga Cao, Jennifer Hamet Bagnou, Laurie Lemoine, Justine Montillot, Agnes Sliwinski, Katia Youssov, Laurent Cleret de Langavant, Emmanuel Dupoux, Anne-Catherine Bachoud-Levi
Summary: Using machine learning and speech features, we were able to predict the clinical performance of Huntington's Disease patients, which could be an efficient method for remote evaluation of individual condition in the future.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
A. -C. Bachoud-Levi
Summary: Huntington's disease is a rare and severe neurodegenerative disorder with no treatment options to stop its progression. Intracerebral transplantation from fetal cells shows potential in restoring disrupted structures and improving symptoms in some patients. However, there are limitations in terms of immune rejection and standardization of the procedure, which require further research and improvement.
REVUE NEUROLOGIQUE
(2022)
Correction
Clinical Neurology
Quang Tuan Remy Nguyen, Juan Dario Ortigoza Escobar, Jean-Marc Burgunder, Caterina Mariotti, Carsten Saft, Lena Elisabeth Hjermind, Katia Youssov, G. Bernhard Landwehrmeyer, Anne-Catherine Bachoud-Levi
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Laurent Cleret de Langavant, Emmanuel Roze, Aimee Petit, Benoit Tressieres, Amin Gharbi-Meliani, Hugo Chaumont, Patrick Pierre Michel, Anne-Catherine Bachoud-Levi, Philippe Remy, Regine Edragas, Annie Lannuzel
Summary: The research found that in the Caribbean, the consumption of Annonaceae products is positively associated with the disease severity and cognitive deficits of patients with degenerative parkinsonism.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Katia Youssov, Etienne Audureau, Henri Vandendriessche, Graca Morgado, Richard Layese, Cyril Goizet, Christophe Verny, Marie-Laure Bourhis, Anne-Catherine Bachoud-Levi
Summary: Our study revealed the different features of caregiver burden in Huntington's disease patients over time. The stage of the disease, severity of decline, psychiatric and behavioral disorders, and their evolution play important roles in the dynamics of caregiver burden.
PARKINSONISM & RELATED DISORDERS
(2022)
Letter
Rehabilitation
Anne-Catherine Bachoud-Levi, Alice Dormeuil, Charlotte Jacquemot
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Behavioral Sciences
Laurie Lemoine, Marine Lunven, Nicolas Fraisse, Katia Youssov, Blanche Bapst, Graca Morgado, Ralf Reilmann, Monica Busse, David Craufurd, Anne Rosser, Vincent de Gardelle, Anne-Catherine Bachoud-Levi
Summary: This study investigated whether patients with Huntington's disease and presymptomatic gene carriers had a deficit in time production tasks and found that HD patients exhibited a clear deficit in temporal production, while Pre-HD participants performed similarly to healthy controls. The ability of temporal production was associated with grey matter volume in the amygdala and caudate, and with clinical assessments of psychomotor and executive functions.
Article
Multidisciplinary Sciences
Carmen Martin-Gomez, Juan Dario Ortigoza-Escobar, Laia Nou-Fontanet, Juan M. Molina-Linde, Anne-Catherine Bachoud-Levi, Juliane Leger, Juan Antonio Blasco-Amaro
Summary: This study aims to explore the values, preferences, and information needs of patients with NKX2-1-related disorders and their caregivers. Qualitative methods will be used to collect data through a focus group and semi-structured interviews, and Grounded Theory will be employed for data analysis. The findings of this study will provide guidance to improve the care given to patients with the studied condition.
Article
Rehabilitation
Eleonore Bayen, Laurent Cleret de Langavant, Katia Youssov, Anne-Catherine Bachoud-Levi
Summary: This study aimed to quantify the burden of informal caregivers (ICs) and identify associated factors. The study found that family burden was closely related to the functional loss and cognitive-behavioral disorders of HD patients. Additionally, the duration of HD and the presence of aggressive symptoms in patients were associated with the subjective burden of caregivers. However, factors such as financial stability, social network, and employment status can alleviate the burden.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Behavioral Sciences
Lorna Le Stanc, Katia Youssov, Maria Giavazzi, Agnes Sliwinski, Anne-Catherine Bachoud-Levi, Charlotte Jacquemot
Summary: This study investigated the role of the striatum in language and decision-making by testing carriers of Huntington's disease (HD) mutations and controls. The results showed that decision parameters better explained the variance in linguistic and non-linguistic tasks than non-decision parameters. In addition, decision parameters were positively correlated with gray matter volume in the ventral striatum and putamen in the linguistic task. These findings suggest that the striatum is involved in language through the modulation of decision-making.
Review
Clinical Neurology
Laia Nou-Fontanet, Carmen Martin-Gomez, Rebeca Isabel-Gomez, Anne-Catherine Bachoud-Levi, Giovanna Zorzi, Alessandro Capuano, Juan Antonio Blasco-Amaro, Juan Dario Ortigoza-Escobar
Summary: This study aimed to provide clinical recommendations for the management of chorea in NKX2-1-RD. The available evidence suggests that methylphenidate may be effective in improving chorea symptoms, but the quality of evidence is low, and more rigorous studies are needed to provide sufficient clinical recommendations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Proceedings Paper
Audiology & Speech-Language Pathology
Rachid Riad, Hadrien Titeux, Xuan Nga Cao, Emmanuel Dupoux, Laurie Lemoine, Justine Montillot, Agnes Sliwinski, Jennifer Hamet Bagnou, Anne-Catherine Bachoud-Levi
Summary: Conversations between clinicians and patients in natural conditions provide valuable information for medical follow-up. This study proposes a comparative evaluation of different methods for automatically analyzing these dialogues to detect and identify speaker turns, especially for individuals with speech disorders. The researchers designed and trained end-to-end neural network architectures and found that their best model achieved 19.5% IER on the test set. They also discovered that clinical markers could be directly extracted from the automatic systems, showing the clinical relevance of their methods.
NINTH WORKSHOP ON SPEECH AND LANGUAGE PROCESSING FOR ASSISTIVE TECHNOLOGIES (SLPAT-2022)
(2022)