New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors

The Glycoscience of Immunity

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Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB–Regulated Gene Network

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Galectin-1 damages cartilage via inflammation

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Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

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Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage

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A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code

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Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing precursors in the cortico-medullary junction

(2015) Lucas Onder et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility

(2015) Harini Krishnan et al.   EXPERIMENTAL CELL RESEARCH

Detection and Automated Scoring of Dicentric Chromosomes in Nonstimulated Lymphocyte Prematurely Condensed Chromosomes After Telomere and Centromere Staining

(2015) Radhia M'kacher et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The Phyre2 web portal for protein modeling, prediction and analysis

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The magic of the sugar code

(2015) Hans-Joachim Gabius   TRENDS IN BIOCHEMICAL SCIENCES

The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity

(2015) Yukinari Kato et al.   Oncotarget

Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms

(2015) Jhon A. Ochoa-Alvarez et al.   Oncotarget

Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration

(2014) Stefan Toegel et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability

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Clinicopathological Correlations of Podoplanin (gp38) Expression in Rheumatoid Synovium and Its Potential Contribution to Fibroblast Platelet Crosstalk

(2014) Manuel J. Del Rey et al.   PLoS One

A Platform of C-type Lectin-like Receptor CLEC-2 for Binding O -Glycosylated Podoplanin and Nonglycosylated Rhodocytin

(2014) Masamichi Nagae et al.   STRUCTURE

Human Articular Chondrocytes Express Multiple Gap Junction Proteins

(2013) Maria D. Mayan et al.   AMERICAN JOURNAL OF PATHOLOGY

Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis

(2013) Maria D Mayan et al.   ANNALS OF THE RHEUMATIC DISEASES

The NF-κB signalling pathway in osteoarthritis

(2013) Stella Rigoglou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Podoplanin and Clusterin Are Reliable Markers of Nonneoplastic Synovium at Various Sites

(2013) Geoffrey Talmon et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell Motility

(2013) Harini Krishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas

(2013) Koji Shindo et al.   Molecular Cancer

Podoplanin is an inflammatory protein upregulated in Th17 cells in SKG arthritic joints

(2013) Yoshiaki Miyamoto et al.   MOLECULAR IMMUNOLOGY

Glycophenotyping of osteoarthritic cartilage and chondrocytes by RT-qPCR, mass spectrometry, histochemistry with plant/human lectins and lectin localization with a glycoprotein

(2013) Stefan Toegel et al.   ARTHRITIS RESEARCH & THERAPY

Reactive Oxygen Species: The 2-Edged Sword of Osteoarthritis

(2012) Ding Li et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Regulation of the metastatic cell phenotype by sialylated glycans

(2012) Matthew J. Schultz et al.   CANCER AND METASTASIS REVIEWS

Oxidative stress as a potential biomarker for determining disease activity in patients with Rheumatoid Arthritis

(2012) Sunanda Kundu et al.   FREE RADICAL RESEARCH

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Podoplanin expression profiles characteristic of odontogenic tumor-specific tissue architectures

(2012) Masayuki Tsuneki et al.   PATHOLOGY RESEARCH AND PRACTICE

Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified by Podoplanin, to Inhibit Transformed Cell Growth and Migration

(2012) Jhon Alberto Ochoa-Alvarez et al.   PLoS One

Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines

(2012) Harumi Inoue et al.   Journal of Oral Science

Podoplanin: emerging functions in development, the immune system, and cancer

(2012) Jillian L. Astarita et al.   Frontiers in Immunology

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

(2011) Diego Mourão-Sá et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Letter to the Glyco-Forum: Effective glycoanalysis with Maackia amurensis lectins requires a clear understanding of their binding specificities

(2011) C. Geisler et al.   GLYCOBIOLOGY

Podoplanin expression in wound and hyperproliferative psoriatic epidermis: Regulation by TGF-β and STAT-3 activating cytokines, IFN-γ, IL-6, and IL-22

(2011) Masaru Honma et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Novel platelet activation receptor CLEC-2: from discovery to prospects

(2011) K. SUZUKI-INOUE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis

(2011) Anna-Karin H Ekwall et al.   ARTHRITIS RESEARCH & THERAPY

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

IL-1β and TNF-α alter the glycophenotype of primary human chondrocytes in vitro

(2010) Martin Pabst et al.   CARBOHYDRATE RESEARCH

GPVI and CLEC-2 in hemostasis and vascular integrity

(2010) S. P. WATSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions

(2009) Leah N. Cueni et al.   EXPERIMENTAL CELL RESEARCH

Phenotype-related differential α-2,6- or α-2,3-sialylation of glycoprotein N-glycans in human chondrocytes

(2009) S. Toegel et al.   OSTEOARTHRITIS AND CARTILAGE

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Uses of plant lectins in bioscience and biomedicine

(2007) Arpad Pusztai   Frontiers in Bioscience-Landmark