More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

(2019) Sara Sdelci et al.   NATURE GENETICS

Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold

(2019) Junya Kawai et al.   ACS Medicinal Chemistry Letters

Micro RNA ‐33a‐5p suppresses colorectal cancer cell growth by inhibiting MTHFD 2

(2019) Yan Yan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma

(2019) Nathanael H. Green et al.   ONCOGENE

The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines

(2019) Yameng Wei et al.   OncoTargets and Therapy

Mitochondrial MTHFD isozymes display distinct expression, regulation, and association with cancer

(2019) R. Nilsson et al.   GENE

Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity

(2019) Junya Kawai et al.   JOURNAL OF MEDICINAL CHEMISTRY

SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function

(2018) Yumeng Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis

(2018) Nirmalya Sen et al.   MOLECULAR CARCINOGENESIS

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mitochondrial one‑carbon metabolic pathway is associated with patient survival in pancreatic cancer

(2018) Kozo Noguchi et al.   Oncology Letters

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

(2018) Juliane Hitzel et al.   Nature Communications

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase

(2018) Wei-Cheng Lin et al.   Cell Reports

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

(2018) Tatsunori Nishimura et al.   ONCOGENE

miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia

(2017) Yueli Gu et al.   ONCOLOGY RESEARCH

Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling

(2017) Babu Sudhamalla et al.   Chemical Science

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

(2017) Chengzhang Fu et al.   Nature Communications

The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis

(2017) Mingfa Liu et al.   Journal of Immunology Research

Gene expression meta-analysis in diffuse low-grade glioma and the corresponding histological subtypes

(2017) Siqi Wang et al.   Scientific Reports

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

(2016) Robert Gustafsson et al.   CANCER RESEARCH

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

(2016) Gregory S. Ducker et al.   Cell Metabolism

Methylenetetrahydrofolate dehydrogenase 2 overexpression is associated with tumor aggressiveness and poor prognosis in hepatocellular carcinoma

(2016) Xincheng Liu et al.   DIGESTIVE AND LIVER DISEASE

Targeting MTHFD2 in acute myeloid leukemia

(2016) Yana Pikman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion

(2016) Costas Koufaris et al.   JOURNAL OF PROTEOME RESEARCH

The importance of mitochondrial folate enzymes in human colorectal cancer

(2016) Masaaki Miyo et al.   ONCOLOGY REPORTS

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species

(2015) Suyeun Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development

(2015) P. M. Tedeschi et al.   MOLECULAR CANCER RESEARCH

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

(2015) Nina Gustafsson Sheppard et al.   Scientific Reports

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion

(2015) Laura Lehtinen et al.   Oncotarget

Mitochondrial MTHFD2L Is a Dual Redox Cofactor-specific Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase Expressed in Both Adult and Embryonic Tissues

(2014) Minhye Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non-Small Cell Lung Cancer Cells

(2014) D. M. Moran et al.   MOLECULAR CANCER THERAPEUTICS

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Increased MTHFD2 expression is associated with poor prognosis in breast cancer

(2014) Feng Liu et al.   TUMOR BIOLOGY

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells

(2012) S. Duygu Selcuklu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Bladder cancer SNP panel predicts susceptibility and survival

(2009) Angeline S. Andrew et al.   HUMAN GENETICS