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Nuclear Folate Metabolism

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Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape

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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

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Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis

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Undercover: gene control by metabolites and metabolic enzymes

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Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

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Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

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Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription

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Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

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BET inhibitor resistance emerges from leukaemia stem cells

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Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

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Phthalimide conjugation as a strategy for in vivo target protein degradation

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Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

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Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protectde NovoThymidylate Biosynthesis during Folate Deficiency

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Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

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Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

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Targeting bromodomains: epigenetic readers of lysine acetylation

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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

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A reversible gene trap collection empowers haploid genetics in human cells

(2013) Tilmann Bürckstümmer et al.   NATURE METHODS

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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

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Nuclear Localization ofde NovoThymidylate Biosynthesis Pathway Is Required to Prevent Uracil Accumulation in DNA

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

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GREAT improves functional interpretation of cis-regulatory regions

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Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

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Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

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