Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

(2020) Pearl Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular landmarks of tumor hypoxia across cancer types

(2019) Vinayak Bhandari et al.   NATURE GENETICS

Reference MicroRNAs for RT-qPCR Assays in Cervical Cancer Patients and Their Application to Studies of HPV16 and Hypoxia Biomarkers

(2019) Anja Nilsen et al.   Translational Oncology

Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer

(2019) Sandhya Chipurupalli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute Hypoxia Profile is a Stronger Prognostic Factor than Chronic Hypoxia in Advanced Stage Head and Neck Cancer Patients

(2019) Martijn van der Heijden et al.   Cancers

Challenges to DNA replication in hypoxic conditions

(2018) Natalie Ng et al.   FEBS Journal

IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers

(2018) Hong Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

(2018) Xinglong Qu et al.   Frontiers in Immunology

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer

(2018) Lingjian Yang et al.   EBioMedicine

Abstract 3030: Immuno PET imaging of PD-L1 expression in syngeneic and human xenograft tumor mouse models using a site-specific89Zr labeled PD-L1 antibody

(2018) Camilla Christensen et al.   CANCER RESEARCH

Single-Photon Emission Computed Tomographic Imaging of the Early Time Course of Therapy-Induced Cell Death Using Technetium 99m Tricarbonyl His-Annexin A5 in a Colorectal Cancer Xenograft Model

(2018) Christel Vangestel et al.   Molecular Imaging

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

(2018) James A Smythies et al.   EMBO REPORTS

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

(2018) Frederike Bensch et al.   NATURE MEDICINE

New horizons in hypoxia signaling pathways

(2017) Christopher W. Pugh et al.   EXPERIMENTAL CELL RESEARCH

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine

(2017) Peter Vaupel et al.   Frontiers in Immunology

Validation of a 15-gene hypoxia classifier in head and neck cancer for prospective use in clinical trials

(2016) Kasper Toustrup et al.   ACTA ONCOLOGICA

Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer

(2016) J J Irlam-Jones et al.   BRITISH JOURNAL OF CANCER

Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer

(2016) Christina S. Fjeldbo et al.   CLINICAL CANCER RESEARCH

Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG

(2016) A. Linge et al.   CLINICAL CANCER RESEARCH

Immuno-oncology: Allying forces of radio- and immuno-therapy to enhance cancer cell killing

(2016) Jacques Bernier   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Sorafenib Increases Tumor Hypoxia in Cervical Cancer Patients Treated With Radiation Therapy: Results of a Phase 1 Clinical Study

(2016) Michael F. Milosevic et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Hypoxia-inducible factors: a central link between inflammation and cancer

(2016) Daniel Triner et al.   JOURNAL OF CLINICAL INVESTIGATION

The tumour hypoxia induced non-coding transcriptome

(2016) Hani Choudhry et al.   MOLECULAR ASPECTS OF MEDICINE

Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma

(2016) Bouchra Tawk et al.   RADIOTHERAPY AND ONCOLOGY

Prognostic value of blood-biomarkers related to hypoxia, inflammation, immune response and tumour load in non-small cell lung cancer – A survival model with external validation

(2016) Sara Carvalho et al.   RADIOTHERAPY AND ONCOLOGY

An evaluation of multiplex bead-based analysis of cytokines and soluble proteins in archived lithium heparin plasma, EDTA plasma and serum samples

(2016) Line Brøndum et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Pathophysiological Basis for the Formation of the Tumor Microenvironment

(2016) Michael R. Horsman et al.   Frontiers in Oncology

Signaling pathways and mechanisms of hypoxia-induced autophagy in the animal cells

(2015) Yungyun Fang et al.   CELL BIOLOGY INTERNATIONAL

Gene Expression Signatures as Biomarkers of Tumour Hypoxia

(2015) B.H.L. Harris et al.   CLINICAL ONCOLOGY

Signature of cytokines and angiogenic factors (CAFs) defines a clinically distinct subgroup of gastric cancer

(2015) Chan-Young Ock et al.   Gastric Cancer

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

Modulation of the tumor vasculature and oxygenation to improve therapy

(2015) Dietmar W. Siemann et al.   PHARMACOLOGY & THERAPEUTICS

Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro

(2015) Brita Singers Sørensen et al.   PLoS One

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer

(2014) H B Ragnum et al.   BRITISH JOURNAL OF CANCER

Mechanisms of Hypoxia-Mediated Immune Escape in Cancer

(2014) I. B. Barsoum et al.   CANCER RESEARCH

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

LET-painting increases tumour control probability in hypoxic tumours

(2013) Niels Bassler et al.   ACTA ONCOLOGICA

HypoxamiRs and Cancer: From Biology to Targeted Therapy

(2013) Harriet E. Gee et al.   ANTIOXIDANTS & REDOX SIGNALING

A 26-Gene Hypoxia Signature Predicts Benefit from Hypoxia-Modifying Therapy in Laryngeal Cancer but Not Bladder Cancer

(2013) A. Eustace et al.   CLINICAL CANCER RESEARCH

Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer

(2013) Charles G. Drake et al.   Nature Reviews Clinical Oncology

Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation

(2013) T. T. Batchelor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunologically augmented cancer treatment using modern radiotherapy

(2013) Marco Durante et al.   TRENDS IN MOLECULAR MEDICINE

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma

(2012) Guy N.J. Betts et al.   EUROPEAN JOURNAL OF CANCER

Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial

(2012) Geert O. Janssens et al.   JOURNAL OF CLINICAL ONCOLOGY

Imaging hypoxia to improve radiotherapy outcome

(2012) Michael R. Horsman et al.   Nature Reviews Clinical Oncology

Hypoxia Gene Expression Signatures as Prognostic and Predictive Markers in Head and Neck Radiotherapy

(2012) Kasper Toustrup et al.   SEMINARS IN RADIATION ONCOLOGY

HIF-1 versus HIF-2 — Is one more important than the other?

(2012) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer

(2011) K. Toustrup et al.   CANCER RESEARCH

Acute Versus Chronic Hypoxia: Why a Simplified Classification is Simply Not Enough

(2011) Christine Bayer et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Metastatic Renal Cell Carcinoma: Relationship Between Initial Metastasis Hypoxia, Change After 1 Month's Sunitinib, and Therapeutic Response: An 18F-Fluoromisonidazole PET/CT Study

(2011) F. Hugonnet et al.   JOURNAL OF NUCLEAR MEDICINE

Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study

(2011) E. Hattingen et al.   NEURO-ONCOLOGY

Identifying pH independent hypoxia induced genes in human squamous cell carcinomasin vitro

(2010) Brita Singers Sørensen et al.   ACTA ONCOLOGICA

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

(2010) F M Buffa et al.   BRITISH JOURNAL OF CANCER

Targeting Hypoxic Cells through the DNA Damage Response

(2010) M. Olcina et al.   CLINICAL CANCER RESEARCH

Improved Intratumoral Oxygenation Through Vascular Normalization Increases Glioma Sensitivity to Ionizing Radiation

(2010) Mackenzie C. McGee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Bevacizumab-induced tumor vessel remodeling in rhabdomyosarcoma xenografts increases the effectiveness of adjuvant ionizing radiation

(2010) Adrianne L. Myers et al.   JOURNAL OF PEDIATRIC SURGERY

Serum Signature of Hypoxia-Regulated Factors Is Associated with Progression after Induction Therapy in Head and Neck Squamous Cell Cancer

(2010) L. A. Byers et al.   MOLECULAR CANCER THERAPEUTICS

Cell surface nucleolin antagonist causes endothelial cell apoptosis and normalization of tumor vasculature

(2009) Valentina Fogal et al.   ANGIOGENESIS

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Plasma Osteopontin, Hypoxia, and Response to Radiotherapy in Nasopharyngeal Cancer

(2008) E. P. Hui et al.   CLINICAL CANCER RESEARCH

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

(2008) C. Camps et al.   CLINICAL CANCER RESEARCH

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers

(2008) Julia Ling-Yu Chen et al.   PLoS Genetics