Signaling pathways and mechanisms of hypoxia-induced autophagy in the animal cells

Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease

(2014) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia–ischemia: Role of protein synthesis and autophagic pathways

(2014) Silvia Carloni et al.   EXPERIMENTAL NEUROLOGY

Inhibition of Autophagy via Activation of PI3K/Akt Pathway Contributes to the Protection of Ginsenoside Rb1 against Neuronal Death Caused by Ischemic Insults

(2014) Tianfei Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia Induces Autophagic Cell Death through Hypoxia-Inducible Factor 1α in Microglia

(2014) Zhao Yang et al.   PLoS One

Autophagy and hippocampal neuronal injury

(2014) Lulu Li et al.   Sleep and Breathing

mTOR signaling and its roles in normal and abnormal brain development

(2014) Nobuyuki Takei et al.   Frontiers in Molecular Neuroscience

Autophagy

(2013) Amber N. Hale et al.   Autophagy

Induction of autophagy restores the loss of sevoflurane cardiac preconditioning seen with prolonged ischemic insult

(2013) Mayumi Shiomi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of autophagy and glycolysis by nitric oxide during hypoxia–reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons

(2013) Gloria A. Benavides et al.   FREE RADICAL BIOLOGY AND MEDICINE

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

(2013) Michalis Papadakis et al.   NATURE MEDICINE

Autophagy in the brain of neonates following hypoxia–ischemia shows sex- and region-specific effects

(2013) S.N. Weis et al.   NEUROSCIENCE

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

(2013) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death

(2012) Xiucui Ma et al.   Autophagy

Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction

(2012) Shihui Xing et al.   Autophagy

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

(2012) T. W. H. Meijer et al.   CLINICAL CANCER RESEARCH

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

mTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy

(2012) Alejandro Gomez-Pinillos et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis

(2012) Yanmei Qi et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Autophagy Contributes to Ischemic Postconditioning-Induced Neuroprotection against Focal Cerebral Ischemia in Rats

(2012) Li Gao et al.   PLoS One

ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK

(2012) Arvin B. Tam et al.   PLoS One

An IFN- -stimulated ATF6-C/EBP- -signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy

(2012) P. Gade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+and ER/Golgi Membrane Network

(2011) Can E. Senkal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia

(2011) N. C. Wolff et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences

(2011) Hakan Cam et al.   Targeted Oncology

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

(2010) Rui Sheng et al.   Autophagy

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia☆

(2010) Xiao-Wen Liu et al.   PHARMACOLOGICAL RESEARCH

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death

(2009) T R Burton et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Autophagy Through Multiple Independent Hypoxic Signaling Pathways

(2009) Kasper Rouschop et al.   CURRENT MOLECULAR MEDICINE

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity

(2009) S. Wilkinson et al.   GENES & DEVELOPMENT

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

(2009) S. Vasseur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

(2008) Dong-Hyung Cho et al.   CANCER LETTERS

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Roles for Protein Kinase Cδ-dependent Signaling Pathways in Acute Hypoxic Stress-induced Autophagy

(2008) Jo-Lin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY