Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

mTOR Pathways in Cancer and Autophagy

(2018) Mathieu Paquette et al.   Cancers

The role of hypoxia-inducible factors in metabolic diseases

(2018) Frank J. Gonzalez et al.   Nature Reviews Endocrinology

Protein disulfide isomerase inhibition synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma

(2017) Jae-Kyung Won et al.   HEPATOLOGY

Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy

(2017) Ying-Ying Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate

(2017) Marco Corazzari et al.   Frontiers in Oncology

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

The hypoxic tumor microenvironment: A driving force for breast cancer progression

(2016) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Activation of UPR Signaling Pathway is Associated With the Malignant Progression and Poor Prognosis in Prostate Cancer

(2016) Junnan Liu et al.   PROSTATE

Anticipatory UPR Activation: A Protective Pathway and Target in Cancer

(2016) David J. Shapiro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ER Stress and Angiogenesis

(2015) François Binet et al.   Cell Metabolism

Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy

(2015) Yu Qiu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia factors suffocate leukemic stem cell initiation

(2015) Mick Bhatia   JOURNAL OF EXPERIMENTAL MEDICINE

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Targeting the IRE1α–XBP1 branch of the unfolded protein response in human diseases

(2015) Dadi Jiang et al.   SEMINARS IN CANCER BIOLOGY

HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets

(2015) Tariq Shah et al.   Oncotarget

A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels

(2015) Bo Kong et al.   Scientific Reports

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

(2015) Agnes Görlach et al.   Redox Biology

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions

(2014) Shane Deegan et al.   Autophagy

Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma

(2014) M Corazzari et al.   CELL DEATH AND DIFFERENTIATION

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

(2014) Yves-Paul Vandewynckel et al.   Hepatology International

MDM2 Regulates Hypoxic Hypoxia-inducible Factor 1α Stability in an E3 Ligase, Proteasome, and PTEN-Phosphatidylinositol 3-Kinase-AKT-dependent Manner

(2014) Shweta Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response

(2014) Nobuhiko Hiramatsu et al.   MOLECULAR BIOLOGY OF THE CELL

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface-Associated GRP78

(2013) Y. R. Miao et al.   CLINICAL CANCER RESEARCH

Protein disulfide isomerase: a promising target for cancer therapy

(2013) Shili Xu et al.   DRUG DISCOVERY TODAY

BiP-bound and nonclustered mode of Ire1 evokes a weak but sustained unfolded protein response

(2013) Yuki Ishiwata-Kimata et al.   GENES TO CELLS

Two phases of disulfide bond formation have differing requirements for oxygen

(2013) Marianne Koritzinsky et al.   JOURNAL OF CELL BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucose regulated protein 78: A critical link between tumor microenvironment and cancer hallmarks

(2012) Zongwei Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factors: Crosstalk between inflammation and metabolism

(2012) Jessica E.S. Shay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Unfolded protein response in cancer: the Physician's perspective

(2011) Xuemei Li et al.   Journal of Hematology & Oncology

Inducible Hsp70 in the Regulation of Cancer Cell Survival: Analysis of Chaperone Induction, Expression and Activity

(2011) Elisa Zorzi et al.   Cancers

The in vitro cleavage of the hAtg proteins by cell death proteases

(2010) Joanna M. Norman et al.   Autophagy

Hypoxia-induced metabolic shifts in cancer cells: Moving beyond the Warburg effect

(2010) Aalim M. Weljie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells

(2010) Zhenyu Ding et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The role of HIF prolyl hydroxylases in tumour growth

(2010) Terhi Jokilehto et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction

(2010) Sanjeev Gupta et al.   PLOS BIOLOGY

GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib

(2009) J. Kern et al.   BLOOD

HIF-1α determines the metastatic potential of gastric cancer cells

(2009) N Rohwer et al.   BRITISH JOURNAL OF CANCER

Activation and clinical significance of the unfolded protein response in breast cancer

(2009) P Scriven et al.   BRITISH JOURNAL OF CANCER

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxygen homeostasis

(2009) Gregg L. Semenza   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

(2008) Michael L. Whitney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Increasing Melanoma Cell Death Using Inhibitors of Protein Disulfide Isomerases to Abrogate Survival Responses to Endoplasmic Reticulum Stress

(2008) P. E. Lovat et al.   CANCER RESEARCH

Critical Role of the Stress Chaperone GRP78/BiP in Tumor Proliferation, Survival, and Tumor Angiogenesis in Transgene-Induced Mammary Tumor Development

(2008) D. Dong et al.   CANCER RESEARCH

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

(2008) Hua-chuan Zheng et al.   HUMAN PATHOLOGY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis

(2008) Hae Kyung Lee et al.   NEURO-ONCOLOGY