Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma

Doxorubicin-resistant osteosarcoma: novel therapeutic approaches in sight?

(2017) Claudia M Hattinger et al.   Future Oncology

PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy

(2017) Iris C. Salaroglio et al.   Molecular Cancer

Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1® can Overcome Drug Resistance in Osteosarcoma

(2016) Marilù Fanelli et al.   CURRENT CANCER DRUG TARGETS

H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance

(2016) Konstantin Chegaev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma

(2016) I. Buondonno et al.   MOLECULAR CANCER THERAPEUTICS

VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal

(2016) Prabhakar Bastola et al.   Molecular Oncology

P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors

(2016) Joanna Kopecka et al.   Oncotarget

The Therapeutic Potential of Cystathionine β-Synthetase/Hydrogen Sulfide Inhibition in Cancer

(2015) Mark R. Hellmich et al.   ANTIOXIDANTS & REDOX SIGNALING

Advances in emerging drugs for osteosarcoma

(2015) Claudia Maria Hattinger et al.   EXPERT OPINION ON EMERGING DRUGS

Role of cystathionine β-synthase in human breast Cancer

(2015) Suvajit Sen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of C/EBP-β LIP in Multidrug Resistance

(2015) Chiara Riganti et al.   JNCI-Journal of the National Cancer Institute

Equilibrated Atomic Models of Outward-Facing P-glycoprotein and Effect of ATP Binding on Structural Dynamics

(2015) Lurong Pan et al.   Scientific Reports

Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

(2015) Xing-Huang Gao et al.   eLife

The Role of C/EBP-β LIP in Multidrug Resistance

(2015) Chiara Riganti et al.   JNCI-Journal of the National Cancer Institute

Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance

(2014) Douglas J. Swartz et al.   BIOSCIENCE REPORTS

Nano carriers that enable co-delivery of chemotherapy and RNAi agents for treatment of drug-resistant cancers

(2014) Vasilios Tsouris et al.   BIOTECHNOLOGY ADVANCES

Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

(2014) Gergely Szakács et al.   CHEMICAL REVIEWS

GYY4137, a hydrogen sulfide (H2S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway

(2014) SEN LU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of invasion and epithelial-mesenchymal transition of human breast cancer cells by hydrogen sulfide through decreased phospho-p38 expression

(2014) MIN LV et al.   Molecular Medicine Reports

Involvement of HIF-1α activation in the doxorubicin resistance of human osteosarcoma cells

(2014) LAURA RONCUZZI et al.   ONCOLOGY REPORTS

Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron

(2014) Tomáš Šimůnek et al.   Pharmacological Reports

Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells

(2013) Tianliang Li et al.   Autophagy

Anthracycline-related cardiotoxicity in childhood cancer survivors

(2013) Steven E. Lipshultz et al.   CURRENT OPINION IN CARDIOLOGY

Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibition of the p38 MAPK pathway in H9c2 cells

(2013) RUNMIN GUO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

(2013) C. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

(2012) Khosrow Kashfi et al.   BIOCHEMICAL PHARMACOLOGY

Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides

(2012) S. Bruce King   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hydrogen Sulfide and Cell Signaling

(2011) Ling Li et al.   Annual Review of Pharmacology and Toxicology

Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity

(2011) Anna Tesei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

H2S Donor, S-Propargyl-Cysteine, Increases CSE in SGC-7901 and Cancer-Induced Mice: Evidence for a Novel Anti-Cancer Effect of Endogenous H2S?

(2011) Kaium MA et al.   PLoS One

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis

(2010) Sophie C. Cazanave et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

New advances in molecular mechanisms and the prevention of adriamycin toxicity by antioxidant nutrients

(2010) Sergio Granados-Principal et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular Symbiosis of CHOP and C/EBP  Isoform LIP Contributes to Endoplasmic Reticulum Stress-Induced Apoptosis

(2010) C.-B. Chiribau et al.   MOLECULAR AND CELLULAR BIOLOGY

C/EBP-β Regulates Endoplasmic Reticulum Stress–Triggered Cell Death in Mouse and Human Models

(2010) Ofir Meir et al.   PLoS One

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY