Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein

Multiple Drug Transport Pathways through Human P-Glycoprotein

(2015) James W. McCormick et al.   BIOCHEMISTRY

The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein

(2015) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beware of docking!

(2015) Yu-Chian Chen   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice

(2015) Ling-Lei Kong et al.   Scientific Reports

Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation

(2014) Tip W. Loo et al.   BIOCHEMICAL PHARMACOLOGY

Translocation mechanism of P-glycoprotein and conformational changes occurring at drug-binding site: Insights from multi-targeted molecular dynamics

(2014) Rameshwar Prajapati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cysteines Introduced into Extracellular Loops 1 and 4 of Human P-Glycoprotein That Are Close Only in the Open Conformation Spontaneously Form a Disulfide Bond That Inhibits Drug Efflux and ATPase Activity

(2014) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Corrector VX-809 stabilizes the first transmembrane domain of CFTR

(2013) Tip W. Loo et al.   BIOCHEMICAL PHARMACOLOGY

Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms

(2013) Tip W. Loo et al.   BIOCHEMISTRY

Drug Rescue Distinguishes between Different Structural Models of Human P-Glycoprotein

(2013) Tip W. Loo et al.   BIOCHEMISTRY

A Salt Bridge in Intracellular Loop 2 Is Essential for Folding of Human P-Glycoprotein

(2013) Tip W. Loo et al.   BIOCHEMISTRY

Protein Contacts and Ligand Binding in the Inward-Facing Model of Human P-Glycoprotein

(2013) Ilza K. Pajeva et al.   ChemMedChem

Locking Intracellular Helices 2 and 3 Together Inactivates Human P-glycoprotein

(2013) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human P-glycoprotein Contains a Greasy Ball-and-Socket Joint at the Second Transmission Interface

(2013) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the Origin of Large Flexibility of P-glycoprotein in the Inward-facing State

(2013) Po-Chao Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of modulators to mouse and human multidrug resistance P-glycoprotein. A computational study

(2013) Gabriel E. Jara et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

(2013) Eduardo E. Chufan et al.   PLoS One

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

(2013) A. B. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

The ATPase Activity of the P-glycoprotein Drug Pump Is Highly Activated When the N-terminal and Central Regions of the Nucleotide-binding Domains Are Linked Closely Together

(2012) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Corrector-mediated rescue of misprocessed CFTR mutants can be reduced by the P-glycoprotein drug pump

(2011) Tip W. Loo et al.   BIOCHEMICAL PHARMACOLOGY

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The “Specific” P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Pavitra Kannan et al.   ACS Chemical Neuroscience

Human P-glycoprotein is active when the two halves are clamped together in the closed conformation

(2010) Tip W. Loo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Residues in the Drug Translocation Pathway of the Human Multidrug Resistance P-glycoprotein by Arginine Mutagenesis

(2009) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-glycoprotein at the Human Blood-Brain Barrier with (R)-11C-Verapamil and PET

(2009) C. C. Wagner et al.   JOURNAL OF NUCLEAR MEDICINE

Correctors promote folding of the CFTR in the endoplasmic reticulum

(2008) Tip W. Loo et al.   BIOCHEMICAL JOURNAL

Arginines in the First Transmembrane Segment Promote Maturation of a P-glycoprotein Processing Mutant by Hydrogen Bond Interactions with Tyrosines in Transmembrane Segment 11

(2008) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing Mutations Disrupt Interactions between the Nucleotide Binding and Transmembrane Domains of P-glycoprotein and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

(2008) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY