Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

Chemotherapeutic Effect of CD147 Antibody-labeled Micelles Encapsulating Doxorubicin Conjugate Targeting CD147-Expressing Carcinoma Cells

(2018)   ANTICANCER RESEARCH

Doxorubicin and rhein loaded nanomicelles attenuates multidrug resistance in human ovarian cancer

(2018) Na-Na Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Risk, Risk Factors, and Surveillance of Subsequent Malignant Neoplasms in Survivors of Childhood Cancer: A Review

(2018) Lucie M. Turcotte et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor targeted delivery of doxorubicin in malignant peripheral nerve sheath tumors

(2018) A. B. Madhankumar et al.   PLoS One

Review: Cell Death, Nucleic Acids, and Immunity

(2018) Keith B. Elkon   Arthritis & Rheumatology

PhytoNanotechnology: Enhancing Delivery of Plant Based Anti-cancer Drugs

(2018) Tabassum Khan et al.   Frontiers in Pharmacology

Daunorubicin, a topoisomerase II poison, suppresses viral production of hepatitis B virus by inducing cGAS-dependent innate immune response

(2018) Hirotaka Imai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TOP2B: The First Thirty Years

(2018) Caroline Austin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor

(2017) Yurui Xu et al.   International Journal of Nanomedicine

A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance

(2017) Jinjin Shi et al.   International Journal of Nanomedicine

Surface-enhanced Raman scattering investigation of targeted delivery and controlled release of gemcitabine

(2017) Ty Santiago et al.   International Journal of Nanomedicine

Application of a lipid-coated hollow calcium phosphate nanoparticle in synergistic co-delivery of doxorubicin and paclitaxel for the treatment of human lung cancer A549 cells

(2017) Chao Wu et al.   International Journal of Nanomedicine

Type I DNA Topoisomerases

(2017) Giovanni Capranico et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion

(2017) Priya Luthra et al.   mBio

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

(2017) Weijun Feng et al.   Nature Communications

Discovery of antitumor anthra[2,3- b ]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties

(2016) Andrey E. Shchekotikhin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

(2016) Olga A Guryanova et al.   NATURE MEDICINE

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

(2016) Yves Pommier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Topoisomerases and the regulation of neural function

(2016) Peter J. McKinnon   NATURE REVIEWS NEUROSCIENCE

Interfacial inhibitors

(2015) Yves Pommier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules

(2015) Angelica Mariani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies

(2015) Simon Gebremeskel et al.   Oncotarget

Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells

(2015) C. M. Manville et al.   Biology Open

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases II  and II  in vertebrate mitochondria

(2014) H. Zhang et al.   NUCLEIC ACIDS RESEARCH

New Mechanistic and Functional Insights into DNA Topoisomerases

(2013) Stefanie Hartman Chen et al.   Annual Review of Biochemistry

Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer

(2013) L Bracci et al.   CELL DEATH AND DIFFERENTIATION

Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response

(2013) Lára Hannesdóttir et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Topoisomerases facilitate transcription of long genes linked to autism

(2013) Ian F. King et al.   NATURE

Transcription-dependent dynamic supercoiling is a short-range genomic force

(2013) Fedor Kouzine et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gene regulation and priming by topoisomerase IIα in embryonic stem cells

(2013) Sudhir Thakurela et al.   Nature Communications

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation

(2013) Swagat Ray et al.   Nature Communications

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

(2013) Baoxu Pang et al.   Nature Communications

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy

(2012) Christian Bailly   CHEMICAL REVIEWS

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα

(2012) Kumiko Samejima et al.   JOURNAL OF CELL BIOLOGY

Synthesis and Biological Activities of Topopyrones

(2012) Paul A. Zaleski et al.   JOURNAL OF NATURAL PRODUCTS

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Model for MLL translocations in therapy-related leukemia involving topoisomerase II -mediated DNA strand breaks and gene proximity

(2012) I. G. Cowell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target genes of Topoisomerase II  regulate neuronal survival and are defined by their chromatin state

(2012) V. K. Tiwari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

(2011) Rui Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II  and DNA-dependent protein kinase

(2011) T. Hisatomi et al.   BLOOD

Chiral ruthenium(II) anthraquinone complexes as dual inhibitors of topoisomerases I and II

(2011) Jun-Feng Kou et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

A Journey in the World of DNA Rings and Beyond

(2009) James C. Wang   Annual Review of Biochemistry

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

(2009) Yves Pommier   CHEMICAL REVIEWS

Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model

(2009) A. B. Madhankumar et al.   MOLECULAR CANCER THERAPEUTICS

2008 FDA drug approvals

(2009) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

NK314, a Topoisomerase II Inhibitor That Specifically Targets the α Isoform

(2008) Eriko Toyoda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

American Society of Clinical Oncology 2008 Clinical Practice Guideline Update: Use of Chemotherapy and Radiation Therapy Protectants

(2008) Martee L. Hensley et al.   JOURNAL OF CLINICAL ONCOLOGY

Topoisomerase IIβ Activates a Subset of Neuronal Genes that Are Repressed in AT-Rich Genomic Environment

(2008) Kuniaki Sano et al.   PLoS One