Insights from In Vivo Studies of Cellular Senescence

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging

(2019) Zsofia Turi et al.   Aging-US

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Autophagy and senescence: A new insight in selected human diseases

(2019) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Notch Signaling Mediates Secondary Senescence

(2019) Yee Voan Teo et al.   Cell Reports

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

(2019) James Chapman et al.   FEBS LETTERS

Cellular Senescence and the Immune System in Cancer

(2019) Luis I. Prieto et al.   GERONTOLOGY

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

(2019) Milica Momcilovic et al.   NATURE

Paracrine roles of cellular senescence in promoting tumourigenesis

(2018) Jose Mario Gonzalez-Meljem et al.   BRITISH JOURNAL OF CANCER

DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk

(2018) Wenbing Xie et al.   CANCER CELL

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

(2018) Georg Schett et al.   Nature Communications

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Endoplasmic Reticulum Unfolded Protein Response, Aging and Exercise: An Update

(2018) Brisamar Estébanez et al.   Frontiers in Physiology

Epigenetic regulation in cell senescence

(2017) Li-Qin Cheng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

(2016) Marissa J. Schafer et al.   DIABETES

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression

(2016) M. Lienhard Schmitz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Loss of Nfkb1 leads to early onset aging

(2016) Giovanna M. Bernal et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs

(2015) Ruping Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging

(2014) David M. Nelson et al.   AGE

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Senescent cells harbour features of the cancer epigenome

(2013) Hazel A. Cruickshanks et al.   NATURE CELL BIOLOGY

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

(2013) Darren J. Baker et al.   Cell Reports

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation

(2011) Yongxing Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Real-time in vivo imaging of p16Ink4areveals cross talk with p53

(2009) Kimi Yamakoshi et al.   JOURNAL OF CELL BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY