Microcellular Environmental Regulation of Silver Nanoparticles in Cancer Therapy: A Critical Review

Endoplasmic reticulum stress: major player in size-dependent inhibition of P-glycoprotein by silver nanoparticles in multidrug-resistant breast cancer cells

(2019) Mohana Krishna Gopisetty et al.   JOURNAL OF NANOBIOTECHNOLOGY

Ångstrom-Scale Silver Particles as a Promising Agent for Low-Toxicity Broad-Spectrum Potent Anticancer Therapy

(2019) Zhen-Xing Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Microphysiological Systems as Enabling Tools for Modeling Complexity in the Tumor Microenvironment and Accelerating Cancer Drug Development

(2019) Hong Nam Kim et al.   ADVANCED FUNCTIONAL MATERIALS

Multifunctional Nanobiohybrid Material Composed of Ag@Bi2Se3/RNA Three-Way Junction/miRNA/Retinoic Acid for Neuroblastoma Differentiation

(2019) Mohsen Mohammadniaei et al.   ACS Applied Materials & Interfaces

Reactive Oxygen Species (ROS)-Based Nanomedicine

(2019) Bowen Yang et al.   CHEMICAL REVIEWS

Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication

(2019) Chunlei Wan et al.   Cell Death & Disease

Characterization of Biosynthesized Silver Nanoparticles Using Lactobacillus rhamnosus GG and its In Vitro Assessment Against Colorectal Cancer Cells

(2019) Seyed Mohammad Ali Aziz Mousavi et al.   Probiotics and Antimicrobial Proteins

Advanced understanding of genetic risk and metabolite signatures in construction workers via cytogenetics and metabolomics analysis

(2019) Ganesan Raja et al.   PROCESS BIOCHEMISTRY

Toxico‐Metabolomics of Engineered Nanomaterials: Progress and Challenges

(2019) Farooq Ahmad et al.   ADVANCED FUNCTIONAL MATERIALS

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

(2019) Tuying Yong et al.   Nature Communications

Mechanoregulation of titanium dioxide nanoparticles in cancer therapy

(2019) Ganesan Raja et al.   Materials Science & Engineering C-Materials for Biological Applications

NMR Metabolomics Reveals Metabolism-Mediated Protective Effects in Liver (HepG2) Cells Exposed to Subtoxic Levels of Silver Nanoparticles

(2018) Joana Carrola et al.   JOURNAL OF PROTEOME RESEARCH

Biomimetic synthesis of silver nanoparticles using Matricaria chamomilla extract and their potential anticancer activity against human lung cancer cells

(2018) Mehdi Dadashpour et al.   Materials Science & Engineering C-Materials for Biological Applications

Metabolomics reveals the depletion of intracellular metabolites in HepG2 cells after treatment with gold nanoparticles

(2018) Jeremie Zander Lindeque et al.   Nanotoxicology

Co-exposure to silver nanoparticles and cadmium induce metabolic adaptation in HepG2 cells

(2018) Renata Rank Miranda et al.   Nanotoxicology

Multi-omics approaches confirm metal ions mediate the main toxicological pathways of metal-bearing nanoparticles in lung epithelial A549 cells

(2018) Susan Dekkers et al.   Environmental Science-Nano

Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells

(2018) Yu-Guo Yuan et al.   Oxidative Medicine and Cellular Longevity

Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

(2017) Yu-Guo Yuan et al.   International Journal of Nanomedicine

Research on the hepatotoxicity mechanism of citrate-modified silver nanoparticles based on metabolomics and proteomics

(2017) Jiabin Xie et al.   Nanotoxicology

Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system

(2017) Ayse Basak Engin et al.   Particle and Fibre Toxicology

From the Cover: Metabolism Modulation in Different Organs by Silver Nanoparticles: An NMR Metabolomics Study of a Mouse Model

(2017) Ivana Jarak et al.   TOXICOLOGICAL SCIENCES

Silver nanoparticles induce hormesis in A549 human epithelial cells

(2017) Mireille M.J.P.E. Sthijns et al.   TOXICOLOGY IN VITRO

Silver nanoparticles: Significance of physicochemical properties and assay interference on the interpretation of in vitro cytotoxicity studies

(2017) Kausar B. Riaz Ahmed et al.   TOXICOLOGY IN VITRO

Glucose capped silver nanoparticles induce cell cycle arrest in HeLa cells

(2017) Elisa Panzarini et al.   TOXICOLOGY IN VITRO

1 H NMR Based Metabolomics Studies of the Toxicity of Titanium Dioxide Nanoparticles in Zebrafish (Danio rerio )

(2017) Ganesan Raja et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

1H-NMR-based Metabolomics Studies of the Toxicity of Mesoporous Carbon Nanoparticles in Zebrafish (Danio rerio)

(2017) Ganesan Raja et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Anti-cancerous effect of albumin coated silver nanoparticles on MDA-MB 231 human breast cancer cell line

(2017) Marzieh Azizi et al.   Scientific Reports

Indocyanine Green-Loaded Silver Nanoparticle@Polyaniline Core/Shell Theranostic Nanocomposites for Photoacoustic/Near-Infrared Fluorescence Imaging-Guided and Single-Light-Triggered Photothermal and Photodynamic Therapy

(2016) Xiaoxiao Tan et al.   ACS Applied Materials & Interfaces

Insights into the impact of silver nanoparticles on human keratinocytes metabolism through NMR metabolomics

(2016) Joana Carrola et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Differential genotoxicity mechanisms of silver nanoparticles and silver ions

(2016) Yan Li et al.   ARCHIVES OF TOXICOLOGY

Silver nanoparticle antimicrobial activity explained by membrane rupture and reactive oxygen generation

(2016) Nandita Dasgupta et al.   Environmental Chemistry Letters

Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis

(2016) Yinghua Li et al.   International Journal of Nanomedicine

Silver nanoparticles interact with the cell membrane and increase endothelial permeability by promoting VE-cadherin internalization

(2016) Xia Sun et al.   JOURNAL OF HAZARDOUS MATERIALS

Prolonged Effects of Silver Nanoparticles on p53/p21 Pathway-Mediated Proliferation, DNA Damage Response, and Methylation Parameters in HT22 Hippocampal Neuronal Cells

(2016) Jennifer Mytych et al.   MOLECULAR NEUROBIOLOGY

Silver Nanoparticles Exhibit the Dose-Dependent Anti-Proliferative Effect against Human Squamous Carcinoma Cells Attenuated in the Presence of Berberine

(2016) Arkadiusz Dziedzic et al.   MOLECULES

Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy

(2016) Bin-Hsu Mao et al.   Nanotoxicology

Varying the morphology of silver nanoparticles results in differential toxicity against micro-organisms, HaCaT keratinocytes and affects skin deposition

(2016) Amy M. Holmes et al.   Nanotoxicology

Metabolomics of silver nanoparticles toxicity in HaCaT cells: structure–activity relationships and role of ionic silver and oxidative stress

(2016) Joana Carrola et al.   Nanotoxicology

Two-Phase Bactericidal Mechanism of Silver Nanoparticles against Burkholderia pseudomallei

(2016) Pawinee Siritongsuk et al.   PLoS One

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent

(2016) Anurag R. Mishra et al.   TOXICOLOGICAL SCIENCES

Oxidative stress generation of silver nanoparticles in three bacterial genera and its relationship with the antimicrobial activity

(2016) M.A. Quinteros et al.   TOXICOLOGY IN VITRO

Novel imatinib-loaded silver nanoparticles for enhanced apoptosis of human breast cancer MCF-7 cells

(2016) Seyed Ataollah Sadat Shandiz et al.   Artificial Cells Nanomedicine and Biotechnology

Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in vitro model of the human gut epithelium

(2016) Katherine M. Williams et al.   JOURNAL OF NANOBIOTECHNOLOGY

Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells

(2016) Jae-Kyo Jeong et al.   Scientific Reports

Physical Principles of Nanoparticle Cellular Endocytosis

(2015) Sulin Zhang et al.   ACS Nano

Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats

(2015) Nuoya Yin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Silver nanoparticles: synthesis, properties, and therapeutic applications

(2015) Liuya Wei et al.   DRUG DISCOVERY TODAY

Silver nanoparticles affect on gene expression of inflammatory and neurodegenerative responses in mouse brain neural cells

(2015) Chin-Lin Huang et al.   ENVIRONMENTAL RESEARCH

Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy

(2015) Sangiliyandi Gurunathan et al.   International Journal of Nanomedicine

Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles

(2015) Josh Slane et al.   Materials Science & Engineering C-Materials for Biological Applications

Molecular mechanism of silver nanoparticles in human intestinal cells

(2015) Linda Böhmert et al.   Nanotoxicology

Nanosilver Incurs an Adaptive Shunt of Energy Metabolism Mode to Glycolysis in Tumor and Nontumor Cells

(2014) Yue Chen et al.   ACS Nano

Inhibition of autophagy enhances the anticancer activity of silver nanoparticles

(2014) Jun Lin et al.   Autophagy

Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts

(2014) Yu-Hsuan Lee et al.   BIOMATERIALS

Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems

(2014) Qingxin Mu et al.   CHEMICAL REVIEWS

Comparison ofin vitrotoxicity of silver ions and silver nanoparticles on human hepatoma cells

(2014) Ivana Vinković Vrček et al.   ENVIRONMENTAL TOXICOLOGY

Analysis of the yeast short-term Crabtree effect and its origin

(2014) Arne Hagman et al.   FEBS Journal

Short and prolonged exposure to hyperglycaemia in human fibroblasts and endothelial cells: Metabolic and osmotic effects

(2014) Noah Moruzzi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mechanisms of nanotoxicity: Generation of reactive oxygen species

(2014) Peter P. Fu et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Influence of silver nanoparticles on the activity of rat liver mitochondrial ATPase

(2014) Mariela Chichova et al.   JOURNAL OF NANOPARTICLE RESEARCH

Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats

(2014) Katherine Williams et al.   Nanotoxicology

Etchable plasmonic nanoparticle probes to image and quantify cellular internalization

(2014) Gary B. Braun et al.   NATURE MATERIALS

Hormesis Effects of Silver Nanoparticles at Non-Cytotoxic Doses to Human Hepatoma Cells

(2014) Zhi-Hao Jiao et al.   PLoS One

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

(2014) Rona Miethling-Graff et al.   TOXICOLOGY IN VITRO

Cytotoxic Potential of Silver Nanoparticles

(2014) Tianlu Zhang et al.   YONSEI MEDICAL JOURNAL

Metabolomics study on the cytotoxicity of graphene

(2014) Guozheng Jiao et al.   RSC Advances

Harnessing Nanomedicine for Mucosal Theranostics—A Silver Bullet at Last?

(2013) Eran Elinav et al.   ACS Nano

Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions

(2013) Dawei Guo et al.   BIOMATERIALS

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Molecular Mechanisms of Toxicity of Silver Nanoparticles in Zebrafish Embryos

(2013) Ronny van Aerle et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Cytotoxicity and ROS production of manufactured silver nanoparticles of different sizes in hepatoma and leukemia cells

(2013) Alicia Avalos et al.   JOURNAL OF APPLIED TOXICOLOGY

Silver nanoparticle induced cytotoxicity, oxidative stress, and DNA damage in CHO cells

(2013) Kumud Kant Awasthi et al.   JOURNAL OF NANOPARTICLE RESEARCH

Cytotoxicity and genotoxicity assessment of silver nanoparticles in mouse

(2013) Yan Li et al.   Nanotoxicology

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Warburg and Crabtree Effects in Premalignant Barrett's Esophagus Cell Lines with Active Mitochondria

(2013) Martin T. Suchorolski et al.   PLoS One

In vitroevaluation of silver nanoparticles on human tumoral and normal cells

(2013) Alicia Ávalos Fúnez et al.   TOXICOLOGY MECHANISMS AND METHODS

Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin

(2013) M.I. Setyawati et al.   Nature Communications

Cytotoxicity of peptide-coated silver nanoparticles on the human intestinal cell line Caco-2

(2012) Linda Böhmert et al.   ARCHIVES OF TOXICOLOGY

Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats

(2012) K. Dziendzikowska et al.   JOURNAL OF APPLIED TOXICOLOGY

Global Gene Expression Profiling of Human Lung Epithelial Cells After Exposure to Nanosilver

(2012) Rasmus Foldbjerg et al.   TOXICOLOGICAL SCIENCES

Effects of Silver Nanoparticles on Primary Mixed Neural Cell Cultures: Uptake, Oxidative Stress and Acute Calcium Responses

(2012) Andrea Haase et al.   TOXICOLOGICAL SCIENCES

Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways

(2012) Porntipa Chairuangkitti et al.   TOXICOLOGY IN VITRO

Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

(2012) JIE ZHENG   Oncology Letters

Revealing silver cytotoxicity using Au nanorods/Ag shell nanostructures: disrupting cell membrane and causing apoptosis through oxidative damage

(2012) Xuelian Cheng et al.   RSC Advances

Induction of Apoptosis in Cancer Cells at Low Silver Nanoparticle Concentrations using Chitosan Nanocarrier

(2011) Pallab Sanpui et al.   ACS Applied Materials & Interfaces

Silver Nanoplate Contrast Agents for in Vivo Molecular Photoacoustic Imaging

(2011) Kimberly A. Homan et al.   ACS Nano

The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles

(2011) Margriet V.D.Z. Park et al.   BIOMATERIALS

Role of reactive oxygen species in the antibacterial mechanism of silver nanoparticles on Escherichia coli O157:H7

(2011) Hengyi Xu et al.   BIOMETALS

Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells

(2011) Alexandre Sarre et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antibacterial coatings on haemodialysis catheters by photochemical deposition of silver nanoparticles

(2011) M. Pollini et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Preparation of Airborne Ag/CNT Hybrid Nanoparticles Using an Aerosol Process and Their Application to Antimicrobial Air Filtration

(2011) Jae Hee Jung et al.   LANGMUIR

Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate

(2011) Katrin Loeschner et al.   Particle and Fibre Toxicology

Role of the Nrf2-heme oxygenase-1 pathway in silver nanoparticle-mediated cytotoxicity

(2011) Su Jin Kang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective

(2011) João S. Teodoro et al.   TOXICOLOGY IN VITRO

Heme oxygenase-1 system and gastrointestinal inflammation: A short review

(2011) Xiao Zhu   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolic alterations in cancer cells and therapeutic implications

(2011) Naima Hammoudi et al.   Chinese Journal of Cancer

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

(2010) Rasmus Foldbjerg et al.   ARCHIVES OF TOXICOLOGY

Signaling gene cascade in silver nanoparticle induced apoptosis

(2010) P. Gopinath et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity

(2010) Helinor J. Johnston et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia

(2010) Katarína Smolková et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

In vitro effects of silver nanoparticles on the mitochondrial respiratory chain

(2010) Cláudio Sérgio Costa et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Silver nanoparticles as a safe preservative for use in cosmetics

(2010) Satoshi Kokura et al.   Nanomedicine-Nanotechnology Biology and Medicine

Study of cytotoxic and therapeutic effects of stable and purified silver nanoparticles on tumor cells

(2010) Prakash D. Nallathamby et al.   Nanoscale

Impact of silver nanoparticles on human cells: Effect of particle size

(2010) Wei Liu et al.   Nanotoxicology

The Role of Surface Functionality on Acute Cytotoxicity, ROS Generation and DNA Damage by Cationic Gold Nanoparticles

(2010) Apiwat Chompoosor et al.   Small

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

(2010) Mei Jing Piao et al.   TOXICOLOGY LETTERS

Cytotoxic effect and apoptosis induction by silver nanoparticles in HeLa cells

(2009) Nobuhiko Miura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

15-Deoxy-Δ 12,14 -prostaglandin J 2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS

(2009) Do-Hee Kim et al.   CARCINOGENESIS

In Vitro Toxicity of Silver Nanoparticles at Noncytotoxic Doses to HepG2 Human Hepatoma Cells

(2009) Koji Kawata et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Application of silver nanoparticles to cotton fabric as an antibacterial textile finish

(2009) Feng Zhang et al.   FIBERS AND POLYMERS

Heme Oxygenase and Carbon Monoxide: Medicine Chemistry and Biological Effects Guest Editor: Yuji Naito Heme Oxygenase-1 is an Essential Cytoprotective Component in Oxidative Tissue Injury Induced by Hemorrhagic Shock

(2009) Toru Takahashi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Silver Nanoparticles in Therapeutics: Development of an Antimicrobial Gel Formulation for Topical Use

(2009) Jaya Jain et al.   MOLECULAR PHARMACEUTICS

Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles

(2009) Jianyong Wang et al.   NEUROTOXICOLOGY

Interactions of silver nanoparticles with primary mouse fibroblasts and liver cells

(2009) S. Arora et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells

(2009) Soohee Kim et al.   TOXICOLOGY IN VITRO

Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism

(2009) Eun-Jung Park et al.   TOXICOLOGY IN VITRO

PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes

(2009) Rasmus Foldbjerg et al.   TOXICOLOGY LETTERS

Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells

(2008) P. V. AshaRani et al.   ACS Nano

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Chemical stability of metallic nanoparticles: A parameter controlling their potential cellular toxicity in vitro

(2008) Mélanie Auffan et al.   ENVIRONMENTAL POLLUTION

Toxicity of silver nanoparticles in zebrafish models

(2008) P V Asharani et al.   NANOTECHNOLOGY

CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae

(2008) Yu-Fang Chang et al.   PROGRESS IN LIPID RESEARCH

Cellular responses induced by silver nanoparticles: In vitro studies

(2008) S. Arora et al.   TOXICOLOGY LETTERS

The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells

(2008) Yi-Hong Hsin et al.   TOXICOLOGY LETTERS

Polysulfone ultrafiltration membranes impregnated with silver nanoparticles show improved biofouling resistance and virus removal

(2008) Katherine Zodrow et al.   WATER RESEARCH