Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy

Silver nanoparticles synthesized from Adenium obesum leaf extract induced DNA damage, apoptosis and autophagy via generation of reactive oxygen species

(2016) Mohammad Abul Farah et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent

(2016) Anurag R. Mishra et al.   TOXICOLOGICAL SCIENCES

Gold nanoparticles induce apoptosis, endoplasmic reticulum stress events and cleavage of cytoskeletal proteins in human neutrophils

(2016) Claudie Noël et al.   TOXICOLOGY IN VITRO

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Sulfidation of silver nanoparticle reduces its toxicity in zebrafish

(2015) G. Prathinkra Devi et al.   AQUATIC TOXICOLOGY

Role of ZnS Nanoparticles on Endoplasmic Reticulum Stress-mediated Apoptosis in Retinal Pigment Epithelial Cells

(2015) Bose Karthikeyan et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Is the autophagy a friend or foe in the silver nanoparticles associated radiotherapy for glioma？

(2015) Hao Wu et al.   BIOMATERIALS

Silver nanoparticles activate endoplasmic reticulum stress signaling pathway in cell and mouse models: The role in toxicity evaluation

(2015) Lingling Huo et al.   BIOMATERIALS

Systematic in vitro nanotoxicity study on anodic alumina nanotubes with engineered aspect ratio: Understanding nanotoxicity by a nanomaterial model

(2015) Ye Wang et al.   BIOMATERIALS

Evaluating the Toxicity of Silver Nanoparticles by Detecting Phosphorylation of Histone H3 in Combination with Flow Cytometry Side-Scattered Light

(2015) Xiaoxu Zhao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Inhalation of titanium dioxide induces endoplasmic reticulum stress-mediated autophagy and inflammation in mice

(2015) Kyeong-Nam Yu et al.   FOOD AND CHEMICAL TOXICOLOGY

Autophagy in DNA Damage Response

(2015) Piotr Czarny et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silver nanoparticles affect the neural development of zebrafish embryos

(2015) Qi Xin et al.   JOURNAL OF APPLIED TOXICOLOGY

Silver Nanoparticles Induce Degradation of the Endoplasmic Reticulum Stress Sensor Activating Transcription Factor-6 Leading to Activation of the NLRP-3 Inflammasome

(2015) Jean-Christophe Simard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins

(2015) Ming Li et al.   JOURNAL OF CELL BIOLOGY

Nanotoxicity: The Toxicity Research Progress of Metal and Metal- Containing Nanoparticles

(2015) Lingling Ding et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Nanoparticles Exacerbate Both Ubiquitin and Heat Shock Protein Expressions in Spinal Cord Injury: Neuroprotective Effects of the Proteasome Inhibitor Carfilzomib and the Antioxidant Compound H-290/51

(2015) Hari S. Sharma et al.   MOLECULAR NEUROBIOLOGY

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

(2015) Hui-Wen Chiu et al.   Nanoscale

Silver nanoparticles impede phorbol myristate acetate-induced monocyte–macrophage differentiation and autophagy

(2015) Yingying Xu et al.   Nanoscale

Synaptic degeneration in rat brain after prolonged oral exposure to silver nanoparticles

(2015) Joanna Skalska et al.   NEUROTOXICOLOGY

Endoplasmic Reticulum Stress in Intestinal Epithelial Cell Function and Inflammatory Bowel Disease

(2015) Katherine Luo et al.   Gastroenterology Research and Practice

Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101

(2015) P Majumder et al.   Cell Death & Disease

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

(2015) Z Liu et al.   Cell Death & Disease

Silver nanoparticle protein corona and toxicity: a mini-review

(2015) Nelson Durán et al.   JOURNAL OF NANOBIOTECHNOLOGY

Cathepsin Inhibition-Induced Lysosomal Dysfunction Enhances Pancreatic Beta-Cell Apoptosis in High Glucose

(2015) Minjeong Jung et al.   PLoS One

The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila

(2015) Anne-Claire Jacomin et al.   PLoS One

Insights into the Cellular Response Triggered by Silver Nanoparticles Using Quantitative Proteomics

(2014) Thiago Verano-Braga et al.   ACS Nano

Less Is More: Long-Term in Vitro Exposure to Low Levels of Silver Nanoparticles Provides New Insights for Nanomaterial Evaluation

(2014) Kristen K. Comfort et al.   ACS Nano

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of autophagy enhances the anticancer activity of silver nanoparticles

(2014) Jun Lin et al.   Autophagy

Endoplasmic reticulum stress associated responses in cancer

(2014) Wen-An Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts

(2014) Yu-Hsuan Lee et al.   BIOMATERIALS

The influence of lysosomal stability of silver nanomaterials on their toxicity to human cells

(2014) Magdiel Inggrid Setyawati et al.   BIOMATERIALS

Amyloid Transition of Ubiquitin on Silver Nanoparticles Produced by Pulsed Laser Ablation in Liquid as a Function of Stabilizer and Single-Point Mutations

(2014) Vincenzo Mangini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, Caenorhabditis elegans

(2014) Jeong-Min Ahn et al.   CHEMOSPHERE

Silver nanoparticles inhibit the gill Na+/K+-ATPase and erythrocyte AChE activities and induce the stress response in adult zebrafish (Danio rerio)

(2014) Kheyrollah Khosravi Katuli et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans

(2014) Elizabeth Q. Contreras et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Phagocytosis of nano-sized titanium dioxide triggers changes in protein acetylation

(2014) Jukka Sund et al.   Journal of Proteomics

The effects of silver ions on copper metabolism in rats

(2014) E. Yu. Ilyechova et al.   Metallomics

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

A general mechanism for intracellular toxicity of metal-containing nanoparticles

(2014) Stefania Sabella et al.   Nanoscale

Transport across the cell-membrane dictates nanoparticle fate and toxicity: a new paradigm in nanotoxicology

(2014) Daniela Guarnieri et al.   Nanoscale

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release

(2014) Anda R Gliga et al.   Particle and Fibre Toxicology

Hormesis Effects of Silver Nanoparticles at Non-Cytotoxic Doses to Human Hepatoma Cells

(2014) Zhi-Hao Jiao et al.   PLoS One

Magnetic iron oxide nanoparticles induce autophagy preceding apoptosis through mitochondrial damage and ER stress in RAW264.7 cells

(2014) Eun-Jung Park et al.   TOXICOLOGY IN VITRO

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

(2014) Rona Miethling-Graff et al.   TOXICOLOGY IN VITRO

Cytotoxic Potential of Silver Nanoparticles

(2014) Tianlu Zhang et al.   YONSEI MEDICAL JOURNAL

The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy

(2014) Mónika Lippai et al.   Biomed Research International

Engineered nanoparticles interacting with cells: size matters

(2014) Li Shang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Why should autophagic flux be assessed?

(2013) Xiao-jie Zhang et al.   ACTA PHARMACOLOGICA SINICA

The emerging role of acetylation in the regulation of autophagy

(2013) Ágnes Bánréti et al.   Autophagy

Substrate recognition in selective autophagy and the ubiquitin–proteasome system

(2013) Anne Schreiber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats

(2013) Wim H. De Jong et al.   BIOMATERIALS

Intracellular trafficking and cellular uptake mechanism of mPEG-PLGA-PLL and mPEG-PLGA-PLL-Gal nanoparticles for targeted delivery to hepatomas

(2013) Peifeng Liu et al.   BIOMATERIALS

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Effects of silver nanoparticles on oxidative DNA damage-repair as a function of p38 MAPK status: A comparative approach using human Jurkat T cells and the nematodeCaenorhabditis elegans

(2013) Nivedita Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Molecular Mechanisms of Toxicity of Silver Nanoparticles in Zebrafish Embryos

(2013) Ronny van Aerle et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Development of biomarker for detecting silver nanoparticles exposure using a GAL4 enhancer trap screening in Drosophila

(2013) Hong Tian et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Tethering complexes in the endocytic pathway: CORVET and HOPS

(2013) Jachen A. Solinger et al.   FEBS Journal

Nanosilver suppresses growth and induces oxidative damage to DNA inCaenorhabditis elegans

(2013) Piper Reid Hunt et al.   JOURNAL OF APPLIED TOXICOLOGY

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function inDrosophila

(2013) Szabolcs Takáts et al.   JOURNAL OF CELL BIOLOGY

Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis

(2013) Assaf D. Rubinstein et al.   JOURNAL OF CELL SCIENCE

Nanoparticle Adhesion to the Cell Membrane and Its Effect on Nanoparticle Uptake Efficiency

(2013) Anna Lesniak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells

(2013) Juan F. Linares et al.   MOLECULAR CELL

Location and membrane sources for autophagosome formation – from ER-mitochondria contact sites to Golgi-endosome-derived carriers

(2013) Shu Ning Chan et al.   MOLECULAR MEMBRANE BIOLOGY

Nano–bio effects: interaction of nanomaterials with cells

(2013) Liang-Chien Cheng et al.   Nanoscale

Direct observation of a single nanoparticle–ubiquitin corona formation

(2013) Feng Ding et al.   Nanoscale

Effects of silver nanoparticles on pregnant dams and embryo-fetal development in rats

(2013) Wook-Joon Yu et al.   Nanotoxicology

Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test

(2013) Jeong-Sup Hong et al.   Nanotoxicology

Mechanisms of genotoxicity. A review ofin vitroandin vivostudies with engineered nanoparticles

(2013) Zuzana Magdolenova et al.   Nanotoxicology

Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration

(2013) Tzu-Ying Lee et al.   Particle and Fibre Toxicology

Mechanism of Silver Nanoparticles Action on Insect Pigmentation Reveals Intervention of Copper Homeostasis

(2013) Najealicka Armstrong et al.   PLoS One

Silver nanoparticles induce endoplasmatic reticulum stress response in zebrafish

(2013) Verena Christen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Silver nanoparticles (AgNPs) cause degeneration of cytoskeleton and disrupt synaptic machinery of cultured cortical neurons

(2013) Fenglian Xu et al.   Molecular Brain

Distribution, Elimination, and Toxicity of Silver Nanoparticles and Silver Ions in Rats after 28-Day Oral Exposure

(2012) Meike van der Zande et al.   ACS Nano

Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles

(2012) Eun-Jeong Yang et al.   BIOMATERIALS

Cell Death by Polyvinylpyrrolidine-Coated Silver Nanoparticles is Mediated by ROS-Dependent Signaling

(2012) Kyeong-Ah Kang et al.   Biomolecules & Therapeutics

Induction of autophagy is essential for monocyte-macrophage differentiation

(2012) Y. Zhang et al.   BLOOD

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Ubiquitination and selective autophagy

(2012) S Shaid et al.   CELL DEATH AND DIFFERENTIATION

Exposure to silver nanoparticles does not affect cognitive outcome or hippocampal neurogenesis in adult mice

(2012) Peidang Liu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Size-Dependent Uptake of Silver Nanoparticles in Daphnia magna

(2012) Chun-Mei Zhao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Autophagy is a survival force via suppression of necrotic cell death

(2012) Han-Ming Shen et al.   EXPERIMENTAL CELL RESEARCH

Endoplasmic reticulum: The unfolded protein response is tangled in neurodegeneration

(2012) Jeroen J.M. Hoozemans et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics

(2012) Niels Hadrup et al.   JOURNAL OF APPLIED TOXICOLOGY

Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice

(2012) Yuying Xue et al.   JOURNAL OF APPLIED TOXICOLOGY

Nigericin-induced Impairment of Autophagic Flux in Neuronal Cells Is Inhibited by Overexpression of Bak

(2012) Junghyun Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

The Possible “Proton Sponge ” Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

(2012) Rikke V Benjaminsen et al.   MOLECULAR THERAPY

DNA damage induced by micro- and nanoparticles--interaction with FPG influences the detection of DNA oxidation in the comet assay

(2012) J. Kain et al.   MUTAGENESIS

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment

(2011) Xiaowei Ma et al.   ACS Nano

Size dependent macrophage responses and toxicological effects of Ag nanoparticles

(2011) Jeongsin Park et al.   CHEMICAL COMMUNICATIONS

Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events

(2011) Kelly Verhelst et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Acute and Chronic Toxicity Effects of Silver Nanoparticles (NPs) onDrosophila melanogaster

(2011) Ales Panacek et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis

(2011) Rui Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells

(2011) Ha Ryong Kim et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Emerging nanomaterials for targeting subcellular organelles

(2011) Jasper G. Huang et al.   Nano Today

Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: Comparison with conventional monocultures

(2011) Jennifer Kasper et al.   Particle and Fibre Toxicology

Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate

(2011) Katrin Loeschner et al.   Particle and Fibre Toxicology

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective

(2011) João S. Teodoro et al.   TOXICOLOGY IN VITRO

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

(2011) David G. McEwan et al.   TRENDS IN CELL BIOLOGY

Clarifying lysosomal storage diseases

(2011) Mark L. Schultz et al.   TRENDS IN NEUROSCIENCES

Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans

(2010) Joel N. Meyer et al.   AQUATIC TOXICOLOGY

Silver nanoparticle applications and human health

(2010) Maqusood Ahamed et al.   CLINICA CHIMICA ACTA

Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles

(2010) Eun-Jung Park et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

In vitro effects of silver nanoparticles on the mitochondrial respiratory chain

(2010) Cláudio Sérgio Costa et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Genotoxic analysis of silver nanoparticles inDrosophila

(2010) EŞref Demir et al.   Nanotoxicology

A critical review of the biological mechanisms underlying thein vivoandin vitrotoxicity of carbon nanotubes: The contribution of physico-chemical characteristics

(2010) Helinor J. Johnston et al.   Nanotoxicology

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction

(2010) Denise N. Johnson-Lyles et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dose-dependent in-vivo toxicity assessment of silver nanoparticle in Wistar rats

(2010) Dhermendra K Tiwari et al.   TOXICOLOGY MECHANISMS AND METHODS

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult zebrafish

(2009) Ji Eun Choi et al.   AQUATIC TOXICOLOGY

The Sequestosome 1/p62 Attenuates Cytokine Gene Expression in Activated Macrophages by Inhibiting IFN Regulatory Factor 8 and TNF Receptor-Associated Factor 6/NF- B Activity

(2009) J. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

The effects of silver nanoparticles on oyster embryos

(2009) Amy H. Ringwood et al.   MARINE ENVIRONMENTAL RESEARCH

Silver Nanoparticles in Therapeutics: Development of an Antimicrobial Gel Formulation for Topical Use

(2009) Jaya Jain et al.   MOLECULAR PHARMACEUTICS

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster

(2009) Maqusood Ahamed et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism

(2009) Eun-Jung Park et al.   TOXICOLOGY IN VITRO

A case of generalized argyria after ingestion of colloidal silver solution

(2008) Yangho Kim et al.   AMERICAN JOURNAL OF INDUSTRIAL MEDICINE

What can be inferred from bacterium–nanoparticle interactions about the potential consequences of environmental exposure to nanoparticles?

(2008) Andrew L. Neal   ECOTOXICOLOGY

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins

(2008) Marie W. Wooten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging methods and tools for environmental risk assessment, decision-making, and policy for nanomaterials: summary of NATO Advanced Research Workshop

(2008) Igor Linkov et al.   JOURNAL OF NANOPARTICLE RESEARCH

Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species

(2008) C. Carlson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Lysosome Biogenesis Mediated by vps-18 Affects Apoptotic Cell Degradation in Caenorhabditis elegans

(2008) Hui Xiao et al.   MOLECULAR BIOLOGY OF THE CELL

Toxicity of silver nanoparticles in zebrafish models

(2008) P V Asharani et al.   NANOTECHNOLOGY

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular responses induced by silver nanoparticles: In vitro studies

(2008) S. Arora et al.   TOXICOLOGY LETTERS

Nanosilver: A nanoproduct in medical application

(2007) X. Chen et al.   TOXICOLOGY LETTERS