Multi-omics approaches confirm metal ions mediate the main toxicological pathways of metal-bearing nanoparticles in lung epithelial A549 cells

Silver nanoparticles induce hormesis in A549 human epithelial cells

(2017) Mireille M.J.P.E. Sthijns et al.   TOXICOLOGY IN VITRO

Promise and peril in nanomedicine: the challenges and needs for integrated systems biology approaches to define health risk

(2017) Sabina Halappanavar et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Differential genotoxicity mechanisms of silver nanoparticles and silver ions

(2016) Yan Li et al.   ARCHIVES OF TOXICOLOGY

Gene expression and metabolic responses of HepG2/C3A cells exposed to flame retardants and dust extracts at concentrations relevant to indoor environmental exposures

(2016) Jinkang Zhang et al.   CHEMOSPHERE

The toxicology of ion-shedding zinc oxide nanoparticles

(2016) Jia Liu et al.   CRITICAL REVIEWS IN TOXICOLOGY

Oxidant generation, DNA damage and cytotoxicity by a panel of engineered nanomaterials in three different human epithelial cell lines

(2016) Waluree Thongkam et al.   MUTAGENESIS

Metal homeostasis disruption and mitochondrial dysfunction in hepatocytes exposed to sub-toxic doses of zinc oxide nanoparticles

(2016) M. Chevallet et al.   Nanoscale

Metabolomics of silver nanoparticles toxicity in HaCaT cells: structure–activity relationships and role of ionic silver and oxidative stress

(2016) Joana Carrola et al.   Nanotoxicology

Emerging systems biology approaches in nanotoxicology: Towards a mechanism-based understanding of nanomaterial hazard and risk

(2016) Pedro M. Costa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Involvement of lysosomal dysfunction in silver nanoparticle-induced cellular damage in A549 human lung alveolar epithelial cells

(2016) Takamitsu Miyayama et al.   Journal of Occupational Medicine and Toxicology

Perturbation of cellular mechanistic system by silver nanoparticle toxicity: Cytotoxic, genotoxic and epigenetic potentials

(2015) Poornima Dubey et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

The Effect of Cerium Oxide Nanoparticle Valence State on Reactive Oxygen Species and Toxicity

(2015) Katherine M. Dunnick et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Pooling and Analysis of Published in Vitro Data: A Proof of Concept Study for the Grouping of Nanoparticles

(2015) Myrtill Simkó et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effect of Fe2O3and ZnO nanoparticles on cytotoxicity and glucose metabolism in lung epithelial cells

(2015) Xiaofeng Lai et al.   JOURNAL OF APPLIED TOXICOLOGY

Negligible particle-specific toxicity mechanism of silver nanoparticles: The role of Ag+ ion release in the cytosol

(2015) Valeria De Matteis et al.   Nanomedicine-Nanotechnology Biology and Medicine

Genotoxic effects of zinc oxide nanoparticles

(2015) Julia Heim et al.   Nanoscale

Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

(2015) Sarah Labib et al.   Particle and Fibre Toxicology

Difference in the toxicity mechanism between ion and nanoparticle forms of silver in the mouse lung and in macrophages

(2015) Yuta Arai et al.   TOXICOLOGY

Molecular basis of carcinogenicity of tungsten alloy particles

(2015) Robert M. Harris et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Endoplasmic reticulum stress and oxidative stress are involved in ZnO nanoparticle-induced hepatotoxicity

(2015) Xia Yang et al.   TOXICOLOGY LETTERS

Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

(2015) Hilal Kocdor et al.   Drug Design Development and Therapy

Human Exposure to Conventional and Nanoparticle-Containing Sprays—A Critical Review

(2014) Sabrina Losert et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release

(2014) Anda R Gliga et al.   Particle and Fibre Toxicology

Gene expression profiles reveal distinct immunological responses of cobalt and cerium dioxide nanoparticles in two in vitro lung epithelial cell models

(2014) Sandra Verstraelen et al.   TOXICOLOGY LETTERS

Direct infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control

(2014) Jennifer A Kirwan et al.   Scientific Data

Mechanisms of toxic action of Ag, ZnO and CuO nanoparticles to selected ecotoxicological test organisms and mammalian cellsin vitro: A comparative review

(2013) Angela Ivask et al.   Nanotoxicology

Investigating oxidative stress and inflammatory responses elicited by silver nanoparticles using high-throughput reporter genes in HepG2 cells: Effect of size, surface coating, and intracellular uptake

(2013) Raju Y. Prasad et al.   TOXICOLOGY IN VITRO

Mechanistic study on the biological effects of silver and gold nanoparticles in Caco-2 cells – Induction of the Nrf2/HO-1 pathway by high concentrations of silver nanoparticles

(2013) Sasitorn Aueviriyavit et al.   TOXICOLOGY LETTERS

Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening

(2012) Andre Nel et al.   ACCOUNTS OF CHEMICAL RESEARCH

The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments

(2012) Soumen Das et al.   BIOMATERIALS

Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats

(2012) Laila M Faddah et al.   BMC Complementary and Alternative Medicine

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Effects of Silver Nanoparticles on the Liver and Hepatocytes In Vitro

(2012) Birgit K. Gaiser et al.   TOXICOLOGICAL SCIENCES

Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways

(2012) Porntipa Chairuangkitti et al.   TOXICOLOGY IN VITRO

Ce3+ Ions Determine Redox-Dependent Anti-apoptotic Effect of Cerium Oxide Nanoparticles

(2011) Ivana Celardo et al.   ACS Nano

Characterization of Isotopic Abundance Measurements in High Resolution FT-ICR and Orbitrap Mass Spectra for Improved Confidence of Metabolite Identification

(2011) Ralf J. M. Weber et al.   ANALYTICAL CHEMISTRY

Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells

(2011) Young Sook Lee et al.   ARCHIVES OF TOXICOLOGY

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA

(2011) Atanas Kamburov et al.   BIOINFORMATICS

Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles

(2011) Kyeongah Kang et al.   TOXICOLOGY LETTERS

Toxicity of silver nanoparticles—Nanoparticle or silver ion?

(2011) Christiane Beer et al.   TOXICOLOGY LETTERS

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

(2010) Rasmus Foldbjerg et al.   ARCHIVES OF TOXICOLOGY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Silver ions induce oxidative stress and intracellular zinc release in human skin fibroblasts

(2009) Miriam M. Cortese-Krott et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties

(2008) Tian Xia et al.   ACS Nano

Profiling of zinc-altered gene expression in human prostate normal vs. cancer cells: a time course study

(2008) Shu-fei Lin et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY