Microphysiological Systems as Enabling Tools for Modeling Complexity in the Tumor Microenvironment and Accelerating Cancer Drug Development
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Microphysiological Systems as Enabling Tools for Modeling Complexity in the Tumor Microenvironment and Accelerating Cancer Drug Development
Authors
Keywords
-
Journal
ADVANCED FUNCTIONAL MATERIALS
Volume -, Issue -, Pages 1807553
Publisher
Wiley
Online
2019-02-26
DOI
10.1002/adfm.201807553
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Biomaterials-based 3D cell printing for next-generation therapeutics and diagnostics
- (2018) Jinah Jang et al. BIOMATERIALS
- Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis
- (2018) Xin Cui et al. BIOMATERIALS
- A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity
- (2018) Norman Sachs et al. CELL
- Advanced maturation of human cardiac tissue grown from pluripotent stem cells
- (2018) Kacey Ronaldson-Bouchard et al. NATURE
- Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
- (2018) Georgios Vlachogiannis et al. SCIENCE
- Modeling trastuzumab-related cardiotoxicity in vitro using human stem cell-derived cardiomyocytes
- (2018) Yosuke K. Kurokawa et al. TOXICOLOGY LETTERS
- Fibroblast-associated tumour microenvironment induces vascular structure-networked tumouroid
- (2018) Sang Woo Lee et al. Scientific Reports
- A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy
- (2018) Shantanu Pradhan et al. Scientific Reports
- 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
- (2018) Amir R. Aref et al. LAB ON A CHIP
- Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies
- (2018) Collin D. Edington et al. Scientific Reports
- Corrigendum: Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model
- (2018) Sharon Wei Ling Lee et al. Frontiers in Immunology
- 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro
- (2017) Robert G. Mannino et al. LAB ON A CHIP
- A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications
- (2017) Duc T. T. Phan et al. LAB ON A CHIP
- Paper-based cell culture platform and its emerging biomedical applications
- (2017) Kelvin Ng et al. Materials Today
- Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
- (2017) Russell W. Jenkins et al. Cancer Discovery
- Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro
- (2017) Ken-ichiro Kamei et al. RSC Advances
- 3D Bioprinting a Cell-Laden Bone Matrix for Breast Cancer Metastasis Study
- (2016) Xuan Zhou et al. ACS Applied Materials & Interfaces
- Metabolic response of lung cancer cells to radiation in a paper-based 3D cell culture system
- (2016) Karen A. Simon et al. BIOMATERIALS
- Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues
- (2016) Petra Kerscher et al. BIOMATERIALS
- Three-dimensional biomimetic model to reconstitute sprouting lymphangiogenesis in vitro
- (2016) Sudong Kim et al. BIOMATERIALS
- Stromal-Based Signatures for the Classification of Gastric Cancer
- (2016) M. T. Uhlik et al. CANCER RESEARCH
- Challenging Roadblocks to Cancer Cure
- (2016) M. Loda CANCER RESEARCH
- Tumor Heterogeneity--A 'Contemporary Concept Founded on Historical Insights and Predictions
- (2016) D. R. Welch CANCER RESEARCH
- Tumor spheroid assembly on hyaluronic acid-based structures: A review
- (2016) Marco P. Carvalho et al. CARBOHYDRATE POLYMERS
- Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions
- (2016) Jennifer Alexander et al. CURRENT OPINION IN CELL BIOLOGY
- PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture
- (2016) Shantanu Pradhan et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- A 3D printed nano bone matrix for characterization of breast cancer cell and osteoblast interactions
- (2016) Wei Zhu et al. NANOTECHNOLOGY
- Organoids as an in vitro model of human development and disease
- (2016) Aliya Fatehullah et al. NATURE CELL BIOLOGY
- Directed migration of cancer cells guided by the graded texture of the underlying matrix
- (2016) JinSeok Park et al. NATURE MATERIALS
- Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases
- (2016) Sophia Frentzas et al. NATURE MEDICINE
- Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity
- (2016) Paul W Burridge et al. NATURE MEDICINE
- Rapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology
- (2016) Jeonghun Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clarifying intact 3D tissues on a microfluidic chip for high-throughput structural analysis
- (2016) Yih Yang Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
- (2016) D. F. Quail et al. SCIENCE
- Collective cell durotaxis emerges from long-range intercellular force transmission
- (2016) R. Sunyer et al. SCIENCE
- Migration Phenotype of Brain-Cancer Cells Predicts Patient Outcomes
- (2016) Chris L. Smith et al. Cell Reports
- Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis
- (2016) Rachael Natrajan et al. PLOS MEDICINE
- 3D microtumors in vitro supported by perfused vascular networks
- (2016) Agua Sobrino et al. Scientific Reports
- Rapid 3D Extrusion of Synthetic Tumor Microenvironments
- (2015) Joshua M. Grolman et al. ADVANCED MATERIALS
- Human astrocytes develop physiological morphology and remain quiescent in a novel 3D matrix
- (2015) Amanda L. Placone et al. BIOMATERIALS
- A paper-based invasion assay: Assessing chemotaxis of cancer cells in gradients of oxygen
- (2015) Bobak Mosadegh et al. BIOMATERIALS
- Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution
- (2015) Nicholas McGranahan et al. CANCER CELL
- Clarifying Tissue Clearing
- (2015) Douglas S. Richardson et al. CELL
- Direct Lineage Reprogramming: Strategies, Mechanisms, and Applications
- (2015) Jun Xu et al. Cell Stem Cell
- Synthetic tumor networks for screening drug delivery systems
- (2015) Balabhaskar Prabhakarpandian et al. JOURNAL OF CONTROLLED RELEASE
- Concave microwell array-mediated three-dimensional tumor model for screening anticancer drug-loaded nanoparticles
- (2015) AhRan Kang et al. Nanomedicine-Nanotechnology Biology and Medicine
- Hydrogels with tunable stress relaxation regulate stem cell fate and activity
- (2015) Ovijit Chaudhuri et al. NATURE MATERIALS
- Combination cancer immunotherapies tailored to the tumour microenvironment
- (2015) Mark J. Smyth et al. Nature Reviews Clinical Oncology
- Bioprinting for cancer research
- (2015) Stephanie Knowlton et al. TRENDS IN BIOTECHNOLOGY
- Erratum: CORRIGENDUM: The Evidence of Glioblastoma Heterogeneity
- (2015) Akio Soeda et al. Scientific Reports
- Engineering Cell-Compatible Paper Chips for Cell Culturing, Drug Screening, and Mass Spectrometric Sensing
- (2015) Qiushui Chen et al. Advanced Healthcare Materials
- Fibroblasts Enhance Migration of Human Lung Cancer Cells in a Paper-Based Coculture System
- (2015) Gulden Camci-Unal et al. Advanced Healthcare Materials
- Nanostructures Control the Hepatocellular Responses to a Cytotoxic Agent “Cisplatin”
- (2015) Shimaa A. Abdellatef et al. Biomed Research International
- Toward the Broad Adoption of 3D Tumor Models in the Cancer Drug Pipeline
- (2015) Megan C. Cox et al. ACS Biomaterials-Science & Engineering
- Spherical Cancer Models in Tumor Biology
- (2015) Louis-Bastien Weiswald et al. NEOPLASIA
- Toward the Broad Adoption of 3D Tumor Models in the Cancer Drug Pipeline
- (2015) Megan C. Cox et al. ACS Biomaterials Science & Engineering
- Neurite Outgrowth on Electrospun Nanofibers with Uniaxial Alignment: The Effects of Fiber Density, Surface Coating, and Supporting Substrate
- (2014) Jingwei Xie et al. ACS Nano
- Lessons from patient-derived xenografts for better in vitro modeling of human cancer
- (2014) Stephen Yiu Chuen Choi et al. ADVANCED DRUG DELIVERY REVIEWS
- 3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs
- (2014) David B. Kolesky et al. ADVANCED MATERIALS
- Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors
- (2014) Rasheena Edmondson et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics
- (2014) Xian Xu et al. BIOMATERIALS
- Three-dimensional in vitro tumor models for cancer research and drug evaluation
- (2014) Xian Xu et al. BIOTECHNOLOGY ADVANCES
- Topographical extracellular matrix cues on anticancer drug-induced cytotoxicity in stem cells
- (2014) Jangho Kim et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
- Dual-Phase, Surface Tension-Based Fabrication Method for Generation of Tumor Millibeads
- (2014) Shantanu Pradhan et al. LANGMUIR
- The present and future role of microfluidics in biomedical research
- (2014) Eric K. Sackmann et al. NATURE
- Pragmatic issues in biomarker evaluation for targeted therapies in cancer
- (2014) Armand de Gramont et al. Nature Reviews Clinical Oncology
- Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation
- (2014) Jessie S. Jeon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
- (2014) A. P. Patel et al. SCIENCE
- Three-dimensional printing of Hela cells for cervical tumor modelin vitro
- (2014) Yu Zhao et al. Biofabrication
- Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis
- (2014) Olivier Frey et al. Nature Communications
- Hypoxia-inducible hydrogels
- (2014) Kyung Min Park et al. Nature Communications
- Emerging Understanding of Multiscale Tumor Heterogeneity
- (2014) Michael J. Gerdes et al. Frontiers in Oncology
- Microfluidics-assisted in vitro drug screening and carrier production
- (2013) Jonathan H. Tsui et al. ADVANCED DRUG DELIVERY REVIEWS
- Miniaturized pre-clinical cancer models as research and diagnostic tools
- (2013) Maria Håkanson et al. ADVANCED DRUG DELIVERY REVIEWS
- The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination
- (2013) Jennifer N. Beck et al. BIOMATERIALS
- 3D printing of biomimetic microstructures for cancer cell migration
- (2013) Tina Qing Huang et al. BIOMEDICAL MICRODEVICES
- Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
- (2013) Jonathan Welti et al. JOURNAL OF CLINICAL INVESTIGATION
- A novel three-dimensional stromal-based model forin vitrochemotherapy sensitivity testing of leukemia cells
- (2013) Omar S. Aljitawi et al. LEUKEMIA & LYMPHOMA
- Tumour heterogeneity and cancer cell plasticity
- (2013) Corbin E. Meacham et al. NATURE
- Influence of tumour micro-environment heterogeneity on therapeutic response
- (2013) Melissa R. Junttila et al. NATURE
- Microenvironmental regulation of tumor progression and metastasis
- (2013) Daniela F Quail et al. NATURE MEDICINE
- CLARITY for mapping the nervous system
- (2013) Kwanghun Chung et al. NATURE METHODS
- Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines
- (2013) Anna C. Luca et al. PLoS One
- Multicellular Tumor Spheroids for Evaluation of Cytotoxicity and Tumor Growth Inhibitory Effects of Nanomedicines In Vitro: A Comparison of Docetaxel-Loaded Block Copolymer Micelles and Taxotere®
- (2013) Andrew S. Mikhail et al. PLoS One
- Application of Concave Microwells to Pancreatic Tumor Spheroids Enabling Anticancer Drug Evaluation in a Clinically Relevant Drug Resistance Model
- (2013) Sang-Eun Yeon et al. PLoS One
- In Vitro Perfused Human Capillary Networks
- (2013) Monica L. Moya et al. TISSUE ENGINEERING PART C-METHODS
- Tumour-on-a-chip provides an optical window into nanoparticle tissue transport
- (2013) Alexandre Albanese et al. Nature Communications
- An integrated in vitro model of perfused tumor and cardiac tissue
- (2013) Monica Moya et al. Stem Cell Research & Therapy
- Nanotopography-guided tissue engineering and regenerative medicine
- (2012) Hong Nam Kim et al. ADVANCED DRUG DELIVERY REVIEWS
- Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation
- (2012) Adam J. Booth et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness
- (2012) Pranav Soman et al. BIOMATERIALS
- Induced Pluripotent Stem Cells: Past, Present, and Future
- (2012) Shinya Yamanaka Cell Stem Cell
- Matrix nanotopography as a regulator of cell function
- (2012) Deok-Ho Kim et al. JOURNAL OF CELL BIOLOGY
- The extracellular matrix: A dynamic niche in cancer progression
- (2012) Pengfei Lu et al. JOURNAL OF CELL BIOLOGY
- Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
- (2012) Geeta Mehta et al. JOURNAL OF CONTROLLED RELEASE
- Nanoparticles-mediated drug delivery approaches for cancer targeting: a review
- (2012) Shaheen Sultana et al. JOURNAL OF DRUG TARGETING
- RhoA mediates flow-induced endothelial sprouting in a 3-D tissue analogue of angiogenesis
- (2012) Jonathan W. Song et al. LAB ON A CHIP
- Classifying collective cancer cell invasion
- (2012) Peter Friedl et al. NATURE CELL BIOLOGY
- Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues
- (2012) Jordan S. Miller et al. NATURE MATERIALS
- Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels
- (2012) Yoojin Shin et al. Nature Protocols
- Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
- (2012) I. K. Zervantonakis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Competitive cell interactions in cancer: a cellular tug of war
- (2012) Laura Wagstaff et al. TRENDS IN CELL BIOLOGY
- Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
- (2011) Matthew W. Conklin et al. AMERICAN JOURNAL OF PATHOLOGY
- 3D in vitro bioengineered tumors based on collagen I hydrogels
- (2011) Christopher S. Szot et al. BIOMATERIALS
- Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning
- (2011) Lara Milane et al. Cancer Cell International
- Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
- (2011) Peter Friedl et al. CELL
- Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
- (2011) T. R. Cox et al. Disease Models & Mechanisms
- The cancer stem cell: premises, promises and challenges
- (2011) Hans Clevers NATURE MEDICINE
- Interstitial flow influences direction of tumor cell migration through competing mechanisms
- (2011) W. J. Polacheck et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer
- (2011) J. Kondo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Analysis of anticancer drugs: A review
- (2011) Susanne Nussbaumer et al. TALANTA
- Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies
- (2011) Vikash P. Chauhan et al. Annual Review of Chemical and Biomolecular Engineering
- Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells
- (2010) Deok-Ho Kim et al. ADVANCED MATERIALS
- High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
- (2010) Yi-Chung Tung et al. ANALYST
- The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles
- (2010) Tae-Hee Kim et al. BIOMATERIALS
- Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
- (2010) Kai Kessenbrock et al. CELL
- Dynamic interplay between the collagen scaffold and tumor evolution
- (2010) Mikala Egeblad et al. CURRENT OPINION IN CELL BIOLOGY
- Biological applications of microfluidic gradient devices
- (2010) Sudong Kim et al. Integrative Biology
- Multicellular tumor spheroids: An underestimated tool is catching up again
- (2010) Franziska Hirschhaeuser et al. JOURNAL OF BIOTECHNOLOGY
- Microarrays for the scalable production of metabolically relevant tumour spheroids: a tool for modulating chemosensitivity traits
- (2010) Heike Hardelauf et al. LAB ON A CHIP
- Three-dimensional tissue culture based on magnetic cell levitation
- (2010) Glauco R. Souza et al. Nature Nanotechnology
- Oxygen-Controlled Three-Dimensional Cultures to Analyze Tumor Angiogenesis
- (2010) Scott S. Verbridge et al. TISSUE ENGINEERING PART A
- Microengineered Platforms for Cell Mechanobiology
- (2009) Deok-Ho Kim et al. Annual Review of Biomedical Engineering
- Organ printing: Tissue spheroids as building blocks
- (2009) Vladimir Mironov et al. BIOMATERIALS
- A physiologically realistic in vitro model of microvascular networks
- (2009) Jenna M. Rosano et al. BIOMEDICAL MICRODEVICES
- Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination
- (2009) B. D. Robinson et al. CLINICAL CANCER RESEARCH
- Advancing science and technology via 3D culture on basement membrane matrix
- (2009) G. Benton et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Simultaneous generation of chemical concentration and mechanical shear stress gradients using microfluidic osmotic flow comparable to interstitial flow
- (2009) Joong Yull Park et al. LAB ON A CHIP
- Spheroid-based drug screen: considerations and practical approach
- (2009) Juergen Friedrich et al. Nature Protocols
- Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation
- (2009) Jessamine P. Winer et al. PLoS One
- Paper-supported 3D cell culture for tissue-based bioassays
- (2009) R. Derda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recent advances in three-dimensional multicellular spheroid culture for biomedical research
- (2008) Ruei-Zhen Lin et al. Biotechnology Journal
- In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor- 1
- (2008) J. Ahamed et al. BLOOD
- Collagen density promotes mammary tumor initiation and progression
- (2008) Paolo P Provenzano et al. BMC Medicine
- Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging
- (2008) Vernella Vickerman et al. LAB ON A CHIP
- Cell migration into scaffolds under co-culture conditions in a microfluidic platform
- (2008) Seok Chung et al. LAB ON A CHIP
- Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis
- (2008) E. A. Murphy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now