The Role of Alternative Lengthening of Telomeres Mechanism in Cancer: Translational and Therapeutic Implications

Telomerase-based cancer therapeutics: a review on their clinical trials

(2020) Nicola Relitti et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Telomere Biology and Human Phenotype

(2019) Kara Turner et al.   Cells

Telomeres and telomerase: three decades of progress

(2019) Jerry W. Shay et al.   NATURE REVIEWS GENETICS

Alternative lengthening of telomeres (ALT) influences survival in soft tissue sarcomas: a systematic review with meta-analysis

(2019) Rita T. Lawlor et al.   BMC CANCER

In perspective: An update on telomere targeting in cancer

(2019) Eric T. Sugarman et al.   MOLECULAR CARCINOGENESIS

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players

(2019) Xiaotian Yuan et al.   ONCOGENE

Epigenetics and MicroRNAs in Cancer

(2018) Alice Ramassone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Telomere sequence content can be used to determine ALT activity in tumours

(2018) Michael Lee et al.   NUCLEIC ACIDS RESEARCH

Telomere Maintenance Mechanisms in Cancer

(2018) Tiago Bordeira Gaspar et al.   Genes

Oligonucleotides Targeting Telomeres and Telomerase in Cancer

(2018) Zachary Schrank et al.   MOLECULES

Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms

(2017) Alaina R. Martinez et al.   GENES CHROMOSOMES & CANCER

Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?

(2017) Luca Pompili et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells

(2017) Graziella Cimino-Reale et al.   Journal of Hematology & Oncology

The C-Circle Assay for alternative-lengthening-of-telomeres activity

(2017) Jeremy D. Henson et al.   METHODS

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

(2017) et al.   Genes

Means to the ends: The role of telomeres and telomere processing machinery in metastasis

(2016) Nathaniel J. Robinson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study

(2016) Ralph Salloum et al.   JOURNAL OF NEURO-ONCOLOGY

Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework

(2016) Fabio Bozzi et al.   Oncotarget

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

(2016) Yang Hu et al.   Scientific Reports

Leiomyosarcoma With Alternative Lengthening of Telomeres Is Associated With Aggressive Histologic Features, Loss of ATRX Expression, and Poor Clinical Outcome

(2015) Jau-Yu Liau et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Alternative lengthening of telomeres phenotype in malignant vascular tumors is highly associated with loss of ATRX expression and is frequently observed in hepatic angiosarcomas

(2015) Jau-Yu Liau et al.   HUMAN PATHOLOGY

Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas

(2015) Jau-Yu Liau et al.   MODERN PATHOLOGY

Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas

(2015) Jen-Chieh Lee et al.   MODERN PATHOLOGY

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis

(2015) Ayalew Tefferi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia

(2015) Gabriela M. Baerlocher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic targeting of replicative immortality

(2015) Paul Yaswen et al.   SEMINARS IN CANCER BIOLOGY

Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

(2015) Hilda A Pickett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies

(2014) Yinghui Li et al.   CANCER RESEARCH

MicroRNA-dependent Regulation of Telomere Maintenance Mechanisms: A Field as Much Unexplored as Potentially Promising

(2014) Francesca Santambrogio et al.   CURRENT PHARMACEUTICAL DESIGN

Telomere Maintenance Mechanisms in Cancer: Clinical Implications

(2014) Roger Reddel   CURRENT PHARMACEUTICAL DESIGN

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

(2014) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

WRN Loss Induces Switching of Telomerase-Independent Mechanisms of Telomere Elongation

(2014) April Renee Sandy Gocha et al.   PLoS One

A new role for histone deacetylase 5 in the maintenance of long telomeres

(2013) Clara Lopes Novo et al.   FASEB JOURNAL

Alternative lengthening of telomeres in normal mammalian somatic cells

(2013) A. A. Neumann et al.   GENES & DEVELOPMENT

Telomerase Suppresses Formation of ALT-Associated Single-Stranded Telomeric C-Circles

(2013) Matthew J. Plantinga et al.   MOLECULAR CANCER RESEARCH

Inhibition of telomerase induces alternative lengthening of telomeres during human esophageal carcinogenesis

(2013) Angela Queisser et al.   Cancer Genetics

Human Sarcomas Are Mosaic for Telomerase-Dependent and Telomerase-Independent Telomere Maintenance Mechanisms

(2012) April R.S. Gocha et al.   AMERICAN JOURNAL OF PATHOLOGY

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

Prognostic Value of Alternative Lengthening of Telomeres–Associated Biomarkers in Uterine Sarcoma and Uterine Carcinosarcoma

(2012) Yoo-Kyung Lee et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance

(2012) L. Venturini et al.   NEURO-ONCOLOGY

Cancer and Telomeres--An ALTernative to Telomerase

(2012) J. W. Shay et al.   SCIENCE

Alternative lengthening of telomeres in hTERT-inhibited laryngeal cancer cells

(2010) Wei Chen et al.   CANCER SCIENCE

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Telomere-Maintenance Mechanisms in Soft-Tissue Malignant Fibrous Histiocytomas

(2009) Toshihiro Matsuo et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma

(2008) R. Villa et al.   CLINICAL CANCER RESEARCH

Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies

(2008) Jennie N. Jeyapalan et al.   INTERNATIONAL JOURNAL OF CANCER

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

(2008) Roberta Benetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY