WRN Loss Induces Switching of Telomerase-Independent Mechanisms of Telomere Elongation

Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells

(2016) Baomin Li et al.   Aging-US

Human Sarcomas Are Mosaic for Telomerase-Dependent and Telomerase-Independent Telomere Maintenance Mechanisms

(2012) April R.S. Gocha et al.   AMERICAN JOURNAL OF PATHOLOGY

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres

(2012) Aaron Mendez-Bermudez et al.   NUCLEIC ACIDS RESEARCH

Modulation of Telomeres in Alternative Lengthening of Telomeres Type I Like Human Cells by the Expression of Werner Protein and Telomerase

(2012) Aisha Siddiqa et al.   Journal of Oncology

Identification of Breast Tumor Mutations in BRCA1 That Abolish Its Function in Homologous DNA Recombination

(2010) D. J.R. Ransburgh et al.   CANCER RESEARCH

Hyper telomere recombination accelerates replicative senescence and may promote premature aging

(2010) R. T. Hagelstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomerase-associated Protein 1, HSP90, and Topoisomerase IIα Associate Directly with the BLM Helicase in Immortalized Cells Using ALT and Modulate Its Helicase Activity Using Telomeric DNA Substrates

(2009) Saumitri Bhattacharyya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 Localization to the Telomere and Its Loss from the Telomere in Response to DNA Damage

(2009) Rahul D. Ballal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1

(2009) Marek Rusin et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres

(2008) A. Muntoni et al.   HUMAN MOLECULAR GENETICS

WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2 B-Mediated Telomere Shortening

(2008) B. Li et al.   MOLECULAR AND CELLULAR BIOLOGY