Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Plasma Replacement Therapy for Alzheimer’s Disease

(2019) Xu-long Ding et al.   Neuroscience Bulletin

Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

(2019) Jordan N Norwood et al.   eLife

Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin

(2019) S. Can Akerman et al.   JOURNAL OF ALZHEIMERS DISEASE

Monocytes in the Peripheral Clearance of Amyloid-β and Alzheimer’s Disease

(2019) Huifang Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota

(2019) Binyin Li et al.   Alzheimers & Dementia

Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model

(2019) Luís Costa-Marques et al.   Translational Neurodegeneration

Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease

(2019) Maya Koronyo-Hamaoui et al.   BRAIN

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: 2. Relationship to amyloid β immunotherapy

(2018) Andrés Crane et al.   Alzheimers & Dementia

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1

(2018) Jenny U. Johansson et al.   Alzheimers & Dementia

The antioxidant xanthorrhizol prevents amyloid-β-induced oxidative modification and inactivation of neprilysin

(2018) Chol Seung Lim et al.   BIOSCIENCE REPORTS

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulation of amyloid-β dynamics and pathology by the circadian clock

(2018) Geraldine J. Kress et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model

(2018) Dario Carradori et al.   Nanomedicine-Nanotechnology Biology and Medicine

Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease

(2018) Zhi-Bin Yao et al.   Neural Regeneration Research

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Clinical Research on Alzheimer’s Disease: Progress and Perspectives

(2018) Bin-Lu Sun et al.   Neuroscience Bulletin

Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice

(2018) Linmei Wang et al.   BRAIN PATHOLOGY

Gender-Dependent Transthyretin Modulation of Brain Amyloid-β Levels: Evidence from a Mouse Model of Alzheimer's Disease

(2018) Sandra Marisa Oliveira et al.   JOURNAL OF ALZHEIMERS DISEASE

Midlife Rheumatoid Arthritis Increases the Risk of Cognitive Impairment Two Decades Later: A Population-Based Study

(2018) Karin Wallin et al.   JOURNAL OF ALZHEIMERS DISEASE

Involvement of Insulin-Degrading Enzyme in Insulin- and Atrial Natriuretic Peptide-Sensitive Internalization of Amyloid-β Peptide in Mouse Brain Capillary Endothelial Cells

(2018) Shingo Ito et al.   JOURNAL OF ALZHEIMERS DISEASE

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain

(2018) Qiaoli Ma et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered peripheral profile of blood cells in Alzheimer disease

(2017) Si-Han Chen et al.   MEDICINE

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

(2017) Jerome Robert et al.   eLife

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases

(2016) Erik N. T. P. Bakker et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Patients that have Undergone Hemodialysis Exhibit Lower Amyloid Deposition in the Brain: Evidence Supporting a Therapeutic Strategy for Alzheimer’s Disease by Removal of Blood Amyloid

(2016) Kazuyoshi Sakai et al.   JOURNAL OF ALZHEIMERS DISEASE

Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model

(2016) Carla M. Yuede et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Associations Between Hepatic Functions and Plasma Amyloid-Beta Levels—Implications for the Capacity of Liver in Peripheral Amyloid-Beta Clearance

(2016) Ye-Ran Wang et al.   MOLECULAR NEUROBIOLOGY

Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease

(2015) Yang Xiang et al.   ACTA NEUROPATHOLOGICA

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Methods to monitor monocytes-mediated amyloid-beta uptake and phagocytosis in the context of adjuvanted immunotherapies

(2015) Maxime Hallé et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

The dynamics of monocytes and microglia in Alzheimer’s disease

(2015) Peter Thériault et al.   Alzheimers Research & Therapy

Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques

(2015) Christian Humpel   Frontiers in Aging Neuroscience

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Alzheimer's disease and chronic periodontitis: Is there an association?

(2014) Sumit Gaur et al.   Geriatrics & Gerontology International

Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer’s-like cognitive decline

(2014) Kenneth E. Bernstein et al.   JOURNAL OF CLINICAL INVESTIGATION

Clearance of Amyloid-Beta in Alzheimer’s Disease: Shifting the Action Site from Center to Periphery

(2014) Yu-Hui Liu et al.   MOLECULAR NEUROBIOLOGY

Association Between Serum Amyloid-Beta and Renal Functions: Implications for Roles of Kidney in Amyloid-Beta Clearance

(2014) Yu-Hui Liu et al.   MOLECULAR NEUROBIOLOGY

Chronic kidney disease is associated with dementia independent of cerebral small-vessel disease

(2014) K. Miwa et al.   NEUROLOGY

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

(2014) Hisham Qosa et al.   NEUROPHARMACOLOGY

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

(2013) Dan Frenkel et al.   Nature Communications

Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta

(2013) Jean-Philippe Michaud et al.   Cell Reports

Chronic Kidney Disease and Cognitive Impairment: A Systematic Review and Meta-Analysis

(2012) Thorleif Etgen et al.   AMERICAN JOURNAL OF NEPHROLOGY

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

(2012) Michelle A Erickson et al.   Journal of Neuroinflammation

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Immunotherapy for Alzheimer disease—the challenge of adverse effects

(2012) Yu-Hui Liu et al.   Nature Reviews Neurology

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Kidney Transplantation Improves Cognitive and Psychomotor Functions in Adult Hemodialysis Patients

(2011) Josipa Radić et al.   AMERICAN JOURNAL OF NEPHROLOGY

Association of Alzheimer disease pathology with abnormal lipid metabolism: The Hisayama Study

(2011) T. Matsuzaki et al.   NEUROLOGY

Plasminogen and plasmin in Alzheimer's disease

(2010) Rachel Barker et al.   BRAIN RESEARCH

Marked cerebral atrophy is correlated with kidney dysfunction in nondisabled adults

(2010) Yusuke Yakushiji et al.   HYPERTENSION RESEARCH

Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-  in a Mouse Model of Alzheimer's Disease

(2010) A. M. S. Hartz et al.   MOLECULAR PHARMACOLOGY

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy

(2009) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy

(2009) Justin Zaghi et al.   ACTA NEUROPATHOLOGICA

Soluble cell adhesion molecules in monocytes of Alzheimer’s disease and mild cognitive impairment

(2009) Tanja Hochstrasser et al.   EXPERIMENTAL GERONTOLOGY

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

(2009) Ji Zhao et al.   Molecular Neurodegeneration

Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease

(2009) Yinxing Liu et al.   MOLECULAR THERAPY

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease

(2008) Hanjun Guan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY