The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins

(2019) Stacy A. Malaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface

(2019) Noboru Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing

(2019) Isabel Prager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer

(2019) John Daly et al.   Frontiers in Immunology

Evolution of sialic acids: Implications in xenotransplant biology

(2018) Anu Paul et al.   XENOTRANSPLANTATION

Decreased Siglec-9 Expression on Natural Killer Cell Subset Associated With Persistent HBV Replication

(2018) Di Zhao et al.   Frontiers in Immunology

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis

(2018) Lenneke A.M. Cornelissen et al.   INTERNATIONAL JOURNAL OF CANCER

Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties

(2017) Huifeng Yu et al.   GLYCOBIOLOGY

Siglec-7 expression is reduced on a natural killer (NK) cell subset of obese humans

(2017) Philip Rosenstock et al.   IMMUNOLOGIC RESEARCH

Hepatitis C virus-induced NK cell activation causes metzincin-mediated CD16 cleavage and impaired antibody-dependent cytotoxicity

(2017) Barbara Oliviero et al.   JOURNAL OF HEPATOLOGY

Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion

(2017) Horst Prescher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Host Immune Responses in HIV-1 Infection: The Emerging Pathogenic Role of Siglecs and Their Clinical Correlates

(2017) Joanna Mikulak et al.   Frontiers in Immunology

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes

(2017) Gitanjali Dharmadhikari et al.   Scientific Reports

Increased expression of Siglec-9 in chronic obstructive pulmonary disease

(2017) Zhilin Zeng et al.   Scientific Reports

Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression

(2016) Robert P. Schleimer et al.   Current Opinion in Allergy and Clinical Immunology

Glycobiology simplified: diverse roles of glycan recognition in inflammation

(2016) Ronald L. Schnaar   JOURNAL OF LEUKOCYTE BIOLOGY

A soluble form of Siglec-9 provides a resistance against Group B Streptococcus (GBS) infection in transgenic mice

(2016) Mitsumasa Saito et al.   MICROBIAL PATHOGENESIS

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

(2016) Richard Beatson et al.   NATURE IMMUNOLOGY

Siglec-7 Defines a Highly Functional Natural Killer Cell Subset and Inhibits Cell-Mediated Activities

(2016) J.-Y. Shao et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Aptamer decorated hyaluronan/chitosan nanoparticles for targeted delivery of 5-fluorouracil to MUC1 overexpressing adenocarcinomas

(2015) Zahra Ghasemi et al.   CARBOHYDRATE POLYMERS

MUC1 (CD227): a multi-tasked molecule

(2015) Vasso Apostolopoulos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sialic acids in cancer biology and immunity

(2015) Oliver M T Pearce et al.   GLYCOBIOLOGY

Lack of Siglec-7 expression identifies a dysfunctional natural killer cell subset associated with liver inflammation and fibrosis in chronic HCV infection

(2015) Stefania Varchetta et al.   GUT

A soluble form of Siglec-9 provides an antitumor benefit against mammary tumor cells expressing MUC1 in transgenic mice

(2014) Yukiko Tomioka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Siglec-7 is an inhibitory receptor on human mast cells and basophils

(2014) Sa'ar Mizrahi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Siglec-7 in Apoptosis in Human Platelets

(2014) Kim Anh Nguyen et al.   PLoS One

Binding of the Sialic Acid-binding Lectin, Siglec-9, to the Membrane Mucin, MUC1, Induces Recruitment of β-Catenin and Subsequent Cell Growth

(2013) Shuhei Tanida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4pos T cells and macrophages

(2013) Stefania Varchetta et al.   Retrovirology

Inhibitory receptor expression on neonatal immune cells

(2012) J. Walk et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Colonic Epithelial Cells Express Specific Ligands for Mucosal Macrophage Immunosuppressive Receptors Siglec-7 and -9

(2012) K. Miyazaki et al.   JOURNAL OF IMMUNOLOGY

Engagement of Siglec-7 Receptor Induces a Pro-Inflammatory Response Selectively in Monocytes

(2012) Stefania Varchetta et al.   PLoS One

Human Xeno-Autoantibodies against a Non-Human Sialic Acid Serve as Novel Serum Biomarkers and Immunotherapeutics in Cancer

(2011) V. Padler-Karavani et al.   CANCER RESEARCH

Siglecs Facilitate HIV-1 Infection of Macrophages through Adhesion with Viral Sialic Acids

(2011) Zhongcheng Zou et al.   PLoS One

Ganglioside DSGb5, preferred ligand for Siglec-7, inhibits NK cell cytotoxicity against renal cell carcinoma cells

(2010) Y. Kawasaki et al.   GLYCOBIOLOGY

Pathologic natural killer cell subset redistribution in HIV-1 infection: new insights in pathophysiology and clinical outcomes

(2010) Enrico Brunetta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

(2010) Jennifer A. Belisle et al.   Molecular Cancer

Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins

(2010) Darius Ghaderi et al.   NATURE BIOTECHNOLOGY

The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia

(2009) E. Brunetta et al.   BLOOD

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

(2009) T. Pham et al.   BLOOD