Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity

Chronic psychosocial stress induces visceral hyperalgesia in mice

(2016) Mónica Tramullas et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy

(2015) Yan Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

(2015) Prasenjit Manna et al.   Metabolic Syndrome and Related Disorders

Toll-like receptor 4 signaling in neurons of trigeminal ganglion contributes to nociception induced by acute pulpitis in rats

(2015) Jia-Ji Lin et al.   Scientific Reports

Exopolysaccharide-Producing Probiotic Lactobacilli Reduce Serum Cholesterol and Modify Enteric Microbiota in ApoE-Deficient Mice

(2014) Lis EE London et al.   JOURNAL OF NUTRITION

Protein Quality and the Protein to Carbohydrate Ratio within a High Fat Diet Influences Energy Balance and the Gut Microbiota In C57BL/6J Mice

(2014) Liam McAllan et al.   PLoS One

Clinical Consequences of Diet-Induced Dysbiosis

(2013) Yee Kwan Chan et al.   ANNALS OF NUTRITION AND METABOLISM

Inflammation, Cytokines and Insulin Resistance: A Clinical Perspective

(2013) Verena Wieser et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain

(2013) Siobhain M. O’ Mahony et al.   BEHAVIOURAL BRAIN RESEARCH

Toll-Like Receptor 4 Regulates Chronic Stress-Induced Visceral Pain in Mice

(2013) Monica Tramullas et al.   BIOLOGICAL PSYCHIATRY

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system

(2013) Laura B. Buckman et al.   BRAIN BEHAVIOR AND IMMUNITY

Exercise-mediated improvements in painful neuropathy associated with prediabetes in mice

(2013) Anna L. Groover et al.   PAIN

Toll-Like Receptor 4 Knockout Mice Are Protected against Endoplasmic Reticulum Stress Induced by a High-Fat Diet

(2013) Nicolas Pierre et al.   PLoS One

Targeting the Microbiota to Address Diet-Induced Obesity: A Time Dependent Challenge

(2013) Siobhan F. Clarke et al.   PLoS One

Review article: probiotics for the treatment of irritable bowel syndrome - focus on lactic acid bacteria

(2012) G. Clarke et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Hypothalamic inflammation: a double-edged sword to nutritional diseases

(2012) Dongsheng Cai et al.   Annals of the New York Academy of Sciences

Chronic Stress-Induced Changes in Pro-Inflammatory Cytokines and Spinal Glia Markers in the Rat: A Time Course Study

(2012) Viktoriya Golovatscka et al.   NEUROIMMUNOMODULATION

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Diabetic Visceral Hypersensitivity Is Associated With Activation of Mitogen-Activated Kinase in Rat Dorsal Root Ganglia

(2011) G. Grabauskas et al.   DIABETES

Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl/6 Mice

(2011) B. L. Guilford et al.   Experimental Diabetes Research

Toll-like receptors in chronic pain

(2011) Lauren Nicotra et al.   EXPERIMENTAL NEUROLOGY

Spinal Microglia Initiate and Maintain Hyperalgesia in a Rat Model of Chronic Pancreatitis

(2011) Pei–Yi Liu et al.   GASTROENTEROLOGY

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

High-fat diet selectively protects against the effects of chronic social stress in the mouse

(2011) B.C. Finger et al.   NEUROSCIENCE

The temporal impact of chronic intermittent psychosocial stress on high-fat diet-induced alterations in body weight

(2011) Beate C. Finger et al.   PSYCHONEUROENDOCRINOLOGY

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation

(2010) Claire Barbier de La Serre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Riluzole Normalizes Early-Life Stress-Induced Visceral Hypersensitivity in Rats: Role of Spinal Glutamate Reuptake Mechanisms

(2010) Romain–Daniel Gosselin et al.   GASTROENTEROLOGY

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

(2010) E F Murphy et al.   GUT

BAMBI (Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor) Reveals the Involvement of the Transforming Growth Factor-  Family in Pain Modulation

(2010) M. Tramullas et al.   JOURNAL OF NEUROSCIENCE

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Role of spinal cord glia in the central processing of peripheral pain perception

(2010) S. Bradesi   NEUROGASTROENTEROLOGY AND MOTILITY

The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat

(2010) D. P Mckernan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse

(2010) Shengli Ding et al.   PLoS One

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

The Role of Glia and the Immune System in the Development and Maintenance of Neuropathic Pain

(2010) Ricardo Vallejo et al.   Pain Practice

Dyslipidemia-Induced Neuropathy in Mice: The Role of oxLDL/LOX-1

(2009) A. M. Vincent et al.   DIABETES

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Effects of Chromium Histidinate on Renal Function, Oxidative Stress, and Heat-Shock Proteins in Fat-Fed and Streptozotocin-Treated Rats

(2009) Ayhan Dogukan et al.   JOURNAL OF RENAL NUTRITION

Colorectal distension-induced prefrontal cortex activation in the Wistar–Kyoto rat: implications for irritable bowel syndrome

(2009) S.M. Gibney et al.   NEUROSCIENCE

Sex differences in functional brain activation during noxious visceral stimulation in rats

(2009) Zhuo Wang et al.   PAIN

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-Regulation in a Rat Model of Chronic Stress

(2008) Sylvie Bradesi et al.   GASTROENTEROLOGY

Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice

(2008) Isabella Bettoni et al.   GLIA

The Efficacy of Probiotics in IBS

(2008) Eamonn M. M. Quigley   JOURNAL OF CLINICAL GASTROENTEROLOGY

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity