- Home
- Publications
- Publication Search
- Publication Details
Title
Leucine Rich Repeat Kinase 2 and Innate Immunity
Authors
Keywords
-
Journal
Frontiers in Neuroscience
Volume 14, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-03-10
DOI
10.3389/fnins.2020.00193
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients
- (2019) Farzaneh Atashrazm et al. MOVEMENT DISORDERS
- LRRK2 in infection: friend or foe?
- (2019) Susanne Herbst et al. ACS Infectious Diseases
- A Comprehensive Analysis of Population Differences in LRRK2 Variant Distribution in Parkinson's Disease
- (2019) Li Shu et al. Frontiers in Aging Neuroscience
- LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production
- (2019) Meiyu Zhang et al. Journal of Translational Medicine
- Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling
- (2019) Yashwanth Subbannayya et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Is Parkinson’s disease a chronic low-grade inflammatory bowel disease?
- (2019) Malvyne Rolli-Derkinderen et al. JOURNAL OF NEUROLOGY
- Recent Developments in LRRK2-Targeted Therapy for Parkinson’s Disease
- (2019) Ye Zhao et al. DRUGS
- Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice
- (2019) Diana Matheoud et al. NATURE
- Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease
- (2019) Vinicius M. Fava et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner
- (2019) Bojan Shutinoski et al. Science Translational Medicine
- The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease
- (2019) Shirley Yin-Yu Pang et al. Translational Neurodegeneration
- Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo
- (2018) Elena Kozina et al. BRAIN
- The impact of murine LRRK2 G2019S transgene overexpression on acute responses to inflammatory challenge
- (2018) Darcy Litteljohn et al. BRAIN BEHAVIOR AND IMMUNITY
- LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages
- (2018) Anetta Härtlova et al. EMBO JOURNAL
- Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
- (2018) Palak Amin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LRRK2 kinase in Parkinson's disease
- (2018) Dario R. Alessi et al. SCIENCE
- An increase in LRRK2 suppresses autophagy and enhances Dectin-1–induced immunity in a mouse model of colitis
- (2018) Tetsuya Takagawa et al. Science Translational Medicine
- Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease
- (2018) Ken Y. Hui et al. Science Translational Medicine
- Leucine-Rich Repeat Kinase 2 Controls the Ca2+/Nuclear Factor of Activated T Cells/IL-2 Pathway during Aspergillus Non-Canonical Autophagy in Dendritic Cells
- (2018) Alicia Yoke Wei Wong et al. Frontiers in Immunology
- Parkin and PINK1 mitigate STING-induced inflammation
- (2018) Danielle A. Sliter et al. NATURE
- New Frontiers in Parkinson's Disease: From Genetics to the Clinic
- (2018) Lamya S. Shihabuddin et al. JOURNAL OF NEUROSCIENCE
- Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
- (2018) Junying Yuan et al. NATURE REVIEWS NEUROSCIENCE
- Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
- (2018) Richard Gordon et al. Science Translational Medicine
- LRRK2 promotes the activation of NLRC4 inflammasome duringSalmonellaTyphimurium infection
- (2017) Weiwei Liu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry
- (2017) Annie J. Lee et al. MOVEMENT DISORDERS
- Gut microbiota and IBD: causation or correlation?
- (2017) Josephine Ni et al. Nature Reviews Gastroenterology & Hepatology
- The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
- (2017) Heather D.E. Booth et al. TRENDS IN NEUROSCIENCES
- Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1
- (2017) Kyung A. Han et al. Frontiers in Cellular Neuroscience
- LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
- (2017) Hien Tran Zhao et al. Molecular Therapy-Nucleic Acids
- Periodontal inflammatory disease is associated with the risk of Parkinson’s disease: a population-based retrospective matched-cohort study
- (2017) Chang-Kai Chen et al. PeerJ
- Leprosy type 1 reaction (formerly reversal reaction)
- (2016) Bernard Naafs et al. CLINICS IN DERMATOLOGY
- LRRK2 autophosphorylation enhances its GTPase activity
- (2016) Zhiyong Liu et al. FASEB JOURNAL
- Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
- (2016) Rakel López de Maturana et al. Journal of Neuroinflammation
- Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers
- (2016) Nicolas Dzamko et al. MOVEMENT DISORDERS
- LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies
- (2016) Nicolas Dzamko et al. MOVEMENT DISORDERS
- Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases
- (2016) Jean Gaschignard et al. PLoS Neglected Tropical Diseases
- A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy
- (2016) Vinicius M. Fava et al. PLoS Neglected Tropical Diseases
- LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation
- (2016) Ruiqing Yan et al. Protein & Cell
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- LRRK2 contributes to monocyte dysregulation in Parkinson’s disease
- (2016) Corinna Bliederhaeuser et al. Acta Neuropathologica Communications
- The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins
- (2015) Mark S. Moehle et al. HUMAN MOLECULAR GENETICS
- Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
- (2015) Isabella Russo et al. Journal of Neuroinflammation
- Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
- (2015) Jimmy Z Liu et al. NATURE GENETICS
- Commensal bacteria direct selective cargo sorting to promote symbiosis
- (2015) Qin Zhang et al. NATURE IMMUNOLOGY
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- Inflammation is genetically implicated in Parkinson’s disease
- (2015) N. Dzamko et al. NEUROSCIENCE
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients
- (2014) Veselin Grozdanov et al. ACTA NEUROPATHOLOGICA
- Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China
- (2014) D Wang et al. GENES AND IMMUNITY
- Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
- (2014) J. Schapansky et al. HUMAN MOLECULAR GENETICS
- An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
- (2014) Y. Zhang et al. JOURNAL OF NEUROSCIENCE
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes
- (2014) T. Raj et al. SCIENCE
- Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
- (2014) Lin Luo et al. Nature Communications
- Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation
- (2014) Bernd K. Gilsbach et al. Frontiers in Molecular Neuroscience
- Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies
- (2013) Paul Davies et al. BIOCHEMICAL JOURNAL
- Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression
- (2013) Peter Reinhardt et al. Cell Stem Cell
- Periodontitis and Gingivitis in Inflammatory Bowel Disease
- (2013) Stephan R. Vavricka et al. INFLAMMATORY BOWEL DISEASES
- LRRK2 and RIPK2 Variants in the NOD 2-Mediated Signaling Pathway Are Associated with Susceptibility to Mycobacterium leprae in Indian Populations
- (2013) Patrick Marcinek et al. PLoS One
- An emerging role for LRRK2 in the immune system
- (2012) Nicolas Dzamko et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Crohn's Disease Susceptibility Genes are Associated With Leprosy in the Vietnamese Population
- (2012) A. V. Grant et al. JOURNAL OF INFECTIOUS DISEASES
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation of NLRC4 is critical for inflammasome activation
- (2012) Yan Qu et al. NATURE
- Large-scale replication and heterogeneity in Parkinson disease genetic loci
- (2012) M. Sharma et al. NEUROLOGY
- Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
- (2012) F. Gillardon et al. NEUROSCIENCE
- The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling
- (2012) Nicolas Dzamko et al. PLoS One
- Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
- (2012) Z. Sheng et al. Science Translational Medicine
- Novel cross-talk within the IKK family controls innate immunity
- (2011) Kristopher Clark et al. BIOCHEMICAL JOURNAL
- Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
- (2011) Taro Kawai et al. IMMUNITY
- Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis
- (2011) Junji Umeno et al. INFLAMMATORY BOWEL DISEASES
- Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
- (2011) Mansoureh Hakimi et al. JOURNAL OF NEURAL TRANSMISSION
- Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study
- (2011) Owen A Ross et al. LANCET NEUROLOGY
- The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
- (2011) Zhihua Liu et al. NATURE IMMUNOLOGY
- LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study
- (2011) S. Sharma et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Misfolded α-synuclein and toll-like receptors: therapeutic targets for Parkinson's disease
- (2011) Dawn Béraud et al. PARKINSONISM & RELATED DISORDERS
- Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation
- (2011) Jonathan Thévenet et al. PLoS One
- 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
- (2010) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- Receptor-interacting protein (RIP) kinase family
- (2010) Duanwu Zhang et al. Cellular & Molecular Immunology
- LRRK2 Is Involved in the IFN- Response and Host Response to Pathogens
- (2010) A. Gardet et al. JOURNAL OF IMMUNOLOGY
- Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
- (2010) Andre Franke et al. NATURE GENETICS
- Genomewide Association Study of Leprosy
- (2010) NEW ENGLAND JOURNAL OF MEDICINE
- Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane
- (2010) D. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LRRK2gene variation and its contribution to Parkinson disease
- (2009) Coro Paisán-Ruiz HUMAN MUTATION
- The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7,in vitro
- (2009) Christian Johannes Gloeckner et al. JOURNAL OF NEUROCHEMISTRY
- The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration
- (2009) C. C.-Y. Ho et al. JOURNAL OF NEUROSCIENCE
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- (2009) Wataru Satake et al. NATURE GENETICS
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Genomewide Association Study of Leprosy
- (2009) Fu-Ren Zhang et al. NEW ENGLAND JOURNAL OF MEDICINE
- RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
- (2009) D.-W. Zhang et al. SCIENCE
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
- (2008) Jeffrey C Barrett et al. NATURE GENETICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started