Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

Extramembranous Regions in G Protein-Coupled Receptors: Cinderella in Receptor Biology?

(2019) Sreetama Pal et al.   JOURNAL OF MEMBRANE BIOLOGY

Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N terminus in chemokine binding

(2019) Martin Gustavsson et al.   Science Signaling

Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning

(2018) Jeremiah D. Heredia et al.   JOURNAL OF IMMUNOLOGY

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

(2018) Timothy F Miles et al.   eLife

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

(2018) Geert Schoofs et al.   Jove-Journal of Visualized Experiments

Structural basis of coreceptor recognition by HIV-1 envelope spike

(2018) Md Munan Shaik et al.   NATURE

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

(2017) Yi Zheng et al.   IMMUNITY

Structure of monomeric Interleukin-8 and its interactions with the N-terminal Binding Site-I of CXCR1 by solution NMR spectroscopy

(2017) Sabrina Berkamp et al.   JOURNAL OF BIOMOLECULAR NMR

C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways

(2017) Jeffrey S. Smith et al.   MOLECULAR PHARMACOLOGY

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

Structural basis of ligand interaction with atypical chemokine receptor 3

(2017) Martin Gustavsson et al.   Nature Communications

Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells

(2017) Lisa Seidel et al.   eLife

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model

(2016) Andrew B. Kleist et al.   BIOCHEMICAL PHARMACOLOGY

Chemokines and their receptors: insights from molecular modeling and crystallography

(2016) Irina Kufareva   CURRENT OPINION IN PHARMACOLOGY

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

(2016) Brian T. DeVree et al.   NATURE

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices

(2016) Melanie P. Wescott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“Chemokine receptors as therapeutic targets: Why aren’t there more drugs?”

(2015) Roberto Solari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists

(2015) Jon Våbenø et al.   Future Medicinal Chemistry

A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

(2015) Chao Tu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

(2015) J. S. Burg et al.   SCIENCE

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Elucidating a Key Component of Cancer Metastasis: CXCL12 (SDF-1α) Binding to CXCR4

(2014) Phanourios Tamamis et al.   Journal of Chemical Information and Modeling

Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation

(2014) Irina Kufareva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution NMR characterization of WTCXCL8 monomer and dimer binding to CXCR1 N-terminal domain

(2014) Prem Raj B. Joseph et al.   PROTEIN SCIENCE

Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

(2013) Joshua H. Y. Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine CXCL1 Dimer Is a Potent Agonist for the CXCR2 Receptor

(2013) Aishwarya Ravindran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Receptor Interactions of Obligate Dimeric Mutant of Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

(2012) Joshua H. Y. Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted CXCL12 (SDF-1) forms dimers under physiological conditions

(2011) Paramita Ray et al.   BIOCHEMICAL JOURNAL

Pharmacological modulation of chemokine receptor function

(2011) DJ Scholten et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore

(2011) Maoqing Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Technical Advance: Surface plasmon resonance-based analysis of CXCL12 binding using immobilized lentiviral particles

(2011) Beatriz Vega et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

(2011) L. J. Drury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epstein-Barr Virus-encoded G Protein-coupled Receptor BILF1 Hetero-oligomerizes with Human CXCR4, Scavenges GαiProteins, and Constitutively Impairs CXCR4 Functioning

(2010) Saskia Nijmeijer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidating the CXCL12/CXCR4 Signaling Network in Chronic Lymphocytic Leukemia through Phosphoproteomics Analysis

(2010) Morgan O'Hayre et al.   PLoS One

Development of a new physics-based internal coordinate mechanics force field and its application to protein loop modeling

(2010) Yelena A. Arnautova et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

The Structural Basis of Peptide-Protein Binding Strategies

(2010) Nir London et al.   STRUCTURE

Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

(2009) Yutaka Kofuku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family

(2009) James W. Murphy et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling