Structure of monomeric Interleukin-8 and its interactions with the N-terminal Binding Site-I of CXCR1 by solution NMR spectroscopy

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

(2016) Yi Zheng et al.   NATURE

Intracellular allosteric antagonism of the CCR9 receptor

(2016) Christine Oswald et al.   NATURE

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

(2015) P. R. B. Joseph et al.   BIOCHEMICAL JOURNAL

A Practical Implicit Membrane Potential for NMR Structure Calculations of Membrane Proteins

(2015) Ye Tian et al.   BIOPHYSICAL JOURNAL

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

(2015) J. S. Burg et al.   SCIENCE

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex

(2015) Dorothea Helmer et al.   RSC Advances

Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1

(2015) Shinn-Jong Jiang et al.   Scientific Reports

CXCL8 – The First Chemokine

(2015) Marco Baggiolini   Frontiers in Immunology

In Silico Analysis Reveals Sequential Interactions and Protein Conformational Changes during the Binding of Chemokine CXCL-8 to Its Receptor CXCR1

(2014) Je-Wen Liou et al.   PLoS One

The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide

(2014) Agnieszka A. Kendrick et al.   PROTEIN SCIENCE

Solution NMR characterization of WTCXCL8 monomer and dimer binding to CXCR1 N-terminal domain

(2014) Prem Raj B. Joseph et al.   PROTEIN SCIENCE

Proline Substitution of Dimer Interface β-strand Residues as a Strategy for the Design of Functional Monomeric Proteins

(2013) Prem Raj B. Joseph et al.   BIOPHYSICAL JOURNAL

Investigation of lysine side chain interactions of interleukin-8 with heparin and other glycosaminoglycans studied by a methylation-NMR approach

(2013) K. Mobius et al.   GLYCOBIOLOGY

Organization and Dynamics of the N-Terminal Domain of Chemokine Receptor CXCR1 in Reverse Micelles: Effect of Graded Hydration

(2013) Arunima Chaudhuri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Optimized Phospholipid Bilayer Nanodiscs Facilitate High-Resolution Structure Determination of Membrane Proteins

(2013) Franz Hagn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Synergistic Interactions between Chemokine Receptor Elements in Recognition of Interleukin-8 by Soluble Receptor Mimics

(2012) Emily F. Barter et al.   BIOCHEMISTRY

Local and Global Dynamics of the G Protein-Coupled Receptor CXCR1

(2011) Sang Ho Park et al.   BIOCHEMISTRY

Interactions of Interleukin-8 with the Human Chemokine Receptor CXCR1 in Phospholipid Bilayers by NMR Spectroscopy

(2011) Sang Ho Park et al.   JOURNAL OF MOLECULAR BIOLOGY

Membrane interaction of the N-terminal domain of chemokine receptor CXCR1

(2010) Sourav Haldar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Probing the Role of CXC Motif in Chemokine CXCL8 for High Affinity Binding and Activation of CXCR1 and CXCR2 Receptors

(2010) Prem Raj B. Joseph et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric variants of IL-8: Effects of side chain substitutions and solution conditions upon dimer formation

(2010) Henry B. Lowman et al.   PROTEIN SCIENCE

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Structural Basis for Differential Binding of the Interleukin-8 Monomer and Dimer to the CXCR1 N-Domain: Role of Coupled Interactions and Dynamics

(2009) Aishwarya Ravindran et al.   BIOCHEMISTRY

Differential Activation and Regulation of CXCR1 and CXCR2 by CXCL8 Monomer and Dimer

(2009) M. W. Nasser et al.   JOURNAL OF IMMUNOLOGY