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Title
The evolution of the TOR pathway and its role in cancer
Authors
Keywords
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Journal
ONCOGENE
Volume 32, Issue 34, Pages 3923-3932
Publisher
Springer Nature
Online
2012-12-18
DOI
10.1038/onc.2012.567
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Note: Only part of the references are listed.- An Animal Model of MYC-Driven Medulloblastoma
- (2012) Yanxin Pei et al. CANCER CELL
- The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
- (2012) Yan Wang et al. CANCER CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity
- (2012) Mathieu Laplante et al. Cell Metabolism
- An overview of the mTOR pathway as a target in cancer therapy
- (2012) Ryan D Gentzler et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
- (2012) Trevor J. Pugh et al. NATURE
- Novel mutations target distinct subgroups of medulloblastoma
- (2012) Giles Robinson et al. NATURE
- Dissecting the genomic complexity underlying medulloblastoma
- (2012) David T. W. Jones et al. NATURE
- Clonal selection drives genetic divergence of metastatic medulloblastoma
- (2012) Xiaochong Wu et al. NATURE
- Subgroup-specific structural variation across 1,000 medulloblastoma genomes
- (2012) Paul A. Northcott et al. NATURE
- BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines
- (2012) Brenden Chen et al. PLoS One
- Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition
- (2012) Kevin Bray et al. PLoS One
- Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses
- (2012) S. Kaur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice
- (2012) S. Menon et al. Science Signaling
- Molecular subgroups of medulloblastoma: the current consensus
- (2011) Michael D. Taylor et al. ACTA NEUROPATHOLOGICA
- AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
- (2011) Ken Inoki et al. Annual Review of Pharmacology and Toxicology
- The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
- (2011) Dan Egan et al. Autophagy
- Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
- (2011) Laura R. Pearce et al. BIOCHEMICAL JOURNAL
- Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors
- (2011) J. K. Altman et al. CLINICAL CANCER RESEARCH
- Emerging roles for mammalian target of rapamycin inhibitors in the treatment of solid tumors and hematological malignancies
- (2011) Nushmia Z. Khokhar et al. CURRENT OPINION IN ONCOLOGY
- The role of LKB1 in lung cancer
- (2011) Montse Sanchez-Cespedes Familial Cancer
- Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein
- (2011) Emily J. Glidden et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The mTOR (Mammalian Target of Rapamycin) Kinase Maintains Integrity of mTOR Complex 2
- (2011) Chien-Hung Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
- (2011) Abdelhafid Saci et al. MOLECULAR CELL
- DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy
- (2011) Yongchao Zhao et al. MOLECULAR CELL
- Everolimus for Advanced Pancreatic Neuroendocrine Tumors
- (2011) James C. Yao et al. NEW ENGLAND JOURNAL OF MEDICINE
- Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer
- (2011) José Baselga et al. NEW ENGLAND JOURNAL OF MEDICINE
- Integrity of mTORC2 is dependent on the rictor Gly-934 site
- (2011) R Aimbetov et al. ONCOGENE
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3 -Mediated Phosphorylation of Rictor
- (2011) C.-H. Chen et al. Science Signaling
- 4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors
- (2010) Qing-Bai She et al. CANCER CELL
- With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
- (2010) Pankaj Kapahi et al. Cell Metabolism
- FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor
- (2010) Chia-Chen Chen et al. DEVELOPMENTAL CELL
- Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome
- (2010) Yoon-Jae Cho et al. JOURNAL OF CLINICAL ONCOLOGY
- Medulloblastoma Comprises Four Distinct Molecular Variants
- (2010) Paul A. Northcott et al. JOURNAL OF CLINICAL ONCOLOGY
- Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses
- (2010) J. K. Altman et al. MOLECULAR PHARMACOLOGY
- Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
- (2010) Matthew R Janes et al. NATURE MEDICINE
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
- (2010) Nathalie Carayol et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies
- (2010) J. H. Lee et al. SCIENCE
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- (2010) D. F. Egan et al. SCIENCE
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- (2010) S. Buonamici et al. Science Translational Medicine
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- (2009) David A. Guertin et al. CANCER CELL
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- (2009) F. Chiarini et al. CANCER RESEARCH
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- (2009) J. Huang et al. CANCER RESEARCH
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- (2009) C. C. Dibble et al. MOLECULAR AND CELLULAR BIOLOGY
- NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
- (2009) T.-J. Liu et al. MOLECULAR CANCER THERAPEUTICS
- Molecular mechanisms of mTOR-mediated translational control
- (2009) Xiaoju Max Ma et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
- (2009) Saskia M. Brachmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
- (2009) Morris E Feldman et al. PLOS BIOLOGY
- Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1
- (2009) Kevin T Jones et al. PLOS BIOLOGY
- Amino acid regulation of TOR complex 1
- (2008) Joseph Avruch et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells
- (2008) Ville Hietakangas et al. BMC CANCER
- Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
- (2008) E. Buck et al. CANCER RESEARCH
- SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs
- (2008) Xiaoju Max Ma et al. CELL
- p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
- (2008) Andrei V. Budanov et al. CELL
- PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel
- (2008) L. Yang et al. CLINICAL CANCER RESEARCH
- Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
- (2008) Tsuneo Ikenoue et al. EMBO JOURNAL
- The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
- (2008) Valeria Facchinetti et al. EMBO JOURNAL
- Tumorigenic activity and therapeutic inhibition of Rheb GTPase
- (2008) K. J. Mavrakis et al. GENES & DEVELOPMENT
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- (2008) D. Hambardzumyan et al. GENES & DEVELOPMENT
- The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling inDrosophila
- (2008) Gábor Juhász et al. JOURNAL OF CELL BIOLOGY
- Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
- (2008) Robert J Motzer et al. LANCET
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
- (2008) Jeffrey A Engelman et al. NATURE MEDICINE
- A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
- (2008) Malene Hansen et al. PLoS Genetics
- Role of the Akt pathway in mRNA translation of interferon-stimulated genes
- (2008) S. Kaur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
- (2008) A. Y. Choo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
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