Antibody–enzyme fusion proteins for cancer therapy

The cytotoxic ribonuclease onconase targets RNA interference (siRNA)

(2011) Hong Zhao et al.   CELL CYCLE

PEGylation of therapeutic proteins

(2010) Simona Jevševar et al.   Biotechnology Journal

Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics☆

(2009) Satoshi Nagata et al.   ADVANCED DRUG DELIVERY REVIEWS

T cell epitope: Friend or Foe? Immunogenicity of biologics in context☆

(2009) Constanze A. Weber et al.   ADVANCED DRUG DELIVERY REVIEWS

Silencing an Inhibitor Unleashes a Cytotoxic Enzyme

(2009) Kimberly A. Dickson et al.   BIOCHEMISTRY

Recombinant Immunotoxins Containing Truncated Bacterial Toxins for the Treatment of Hematologic Malignancies

(2009) Robert J. Kreitman   BIODRUGS

Catalytic antibodies: balancing between Dr. Jekyll and Mr. Hyde

(2009) Alexey Belogurov et al.   BIOESSAYS

Comparison of the structural and functional properties of RNase A and BS-RNase: A stepwise mutagenesis approach

(2009) Carmine Ercole et al.   BIOPOLYMERS

alpha-Sarcin catalytic activity is not required for cytotoxicity

(2009) Spencer C Alford et al.   BMC BIOCHEMISTRY

A Caspase-6 and Anti-HER2 Antibody Chimeric Tumor-Targeted Proapoptotic Molecule Decreased Metastasis of Human Osteosarcoma

(2009) Li-Feng Wang et al.   CANCER INVESTIGATION

Construction and Characterization of Novel, Recombinant Immunotoxins Targeting the Her2/neu Oncogene Product: In vitro and In vivo Studies

(2009) Y. Cao et al.   CANCER RESEARCH

Humanized immunotoxins: A new generation of immunotoxins for targeted cancer therapy

(2009) Mrudula Mathew et al.   CANCER SCIENCE

Antibody-Directed Enzyme Prodrug Therapy: A Promising Approach for a Selective Treatment of Cancer Based on Prodrugs and Monoclonal Antibodies

(2009) Lutz F. Tietze et al.   Chemical Biology & Drug Design

Reducing risk, improving outcomes: Bioengineering less immunogenic protein therapeutics

(2009) Anne S. De Groot et al.   CLINICAL IMMUNOLOGY

Targeting: The ADEPT Story So Far

(2009) K. Bagshawe   CURRENT DRUG TARGETS

Development of Novel, Highly Cytotoxic Fusion Constructs Containing Granzyme B: Unique Mechanisms and Functions

(2009) M. Rosenblum et al.   CURRENT PHARMACEUTICAL DESIGN

Ribonucleases as potential modalities in anticancer therapy

(2009) Wojciech Ardelt et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Human anti-ErbB2 immunoagents - immunoRNases and compact antibodies

(2009) Claudia De Lorenzo et al.   FEBS Journal

Antigen-specific Proteolysis by Hybrid Antibodies Containing Promiscuous Proteolytic Light Chains Paired with an Antigen-binding Heavy Chain

(2009) Gopal Sapparapu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Human Antitumor Dimeric ImmunoRNase

(2009) Gennaro Riccio et al.   JOURNAL OF IMMUNOTHERAPY

Developing bifunctionalβ-lactamase molecules with built-in target-recognizing module for prodrug therapy: identification ofEnterobacter CloacaeP99 cephalosporinase loops suitable for randomization and phage-display selection

(2009) Girja S. Shukla et al.   JOURNAL OF MOLECULAR RECOGNITION

Improving GPX activity of selenium-containing human single-chain Fv antibody by site-directed mutation based on the structural analysis

(2009) Junjie Xu et al.   JOURNAL OF MOLECULAR RECOGNITION

Humanized ADEPT comprised of an engineered human purine nucleoside phosphorylase and a tumor targeting peptide for treatment of cancer

(2009) S. Afshar et al.   MOLECULAR CANCER THERAPEUTICS

Mutational and inhibitory analysis of a catalytic antibody. Implication for drug discovery

(2009) Denis Phichith et al.   MOLECULAR IMMUNOLOGY

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

(2008) Greg M. Thurber et al.   ADVANCED DRUG DELIVERY REVIEWS

RNase-induced apoptosis: Fate of calcium-activated potassium channels

(2008) Olga N. Ilinskaya et al.   BIOCHIMIE

Binase and other microbial RNases as potential anticancer agents

(2008) Alexander A. Makarov et al.   BIOESSAYS

Design and synthesis of a β-lactamase activated 5-fluorouracil prodrug

(2008) Ryan M. Phelan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Human antibody RNase fusion protein targeting CD30+ lymphomas

(2008) C. Menzel et al.   BLOOD

Catalytic Activity of Certain Antibodies as a Potential Tool for Drug Synthesis and for Directed Prodrug Therapies

(2008) T. Wojcik et al.   CURRENT MEDICINAL CHEMISTRY

Design of Cytotoxic Ribonucleases by Cationization to Enhance Intracellular Protein Delivery

(2008) Junichiro Futami et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity

(2008) Thomas Rutkoski et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Targeted therapy of cancer using diphtheria toxin-derived immunotoxins

(2008) Sirisha Potala et al.   DRUG DISCOVERY TODAY

Ranpirnase (Onconase®), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy

(2008) Intae Lee   EXPERT OPINION ON BIOLOGICAL THERAPY

RNase A ribonucleases and host defense: an evolving story

(2008) Helene F. Rosenberg   JOURNAL OF LEUKOCYTE BIOLOGY

Human catalytic antibody Se-scFv-B3 with high glutathione peroxidase activity

(2008) Rui Huo et al.   JOURNAL OF MOLECULAR RECOGNITION

Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids

(2008) M. E. Ackerman et al.   MOLECULAR CANCER THERAPEUTICS

Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes

(2008) B. Stahnke et al.   MOLECULAR CANCER THERAPEUTICS

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Barnase as a New Therapeutic Agent Triggering Apoptosis in Human Cancer Cells

(2008) Evelina Edelweiss et al.   PLoS One

Catalytic methods for the destruction of chemical warfare agents under ambient conditions

(2007) Bryan M. Smith   CHEMICAL SOCIETY REVIEWS

The Buried Diversity of Bovine Seminal Ribonuclease: Shape and Cytotoxicity of the Swapped Non-covalent Form of the Enzyme

(2007) Antonello Merlino et al.   JOURNAL OF MOLECULAR BIOLOGY