Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines

Next-generation disulfide stapling: reduction and functional re-bridging all in one

(2016) Maximillian T. W. Lee et al.   Chemical Science

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

(2015) João P. M. Nunes et al.   CHEMICAL COMMUNICATIONS

A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging

(2015) Sally A. Fletcher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

(2015) Mark E. B. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

Homogeneous Bispecifics by Disulfide Bridging

(2014) Elizabeth A. Hull et al.   BIOCONJUGATE CHEMISTRY

Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds

(2014) Cristina Marculescu et al.   CHEMICAL COMMUNICATIONS

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

(2014) Felix F. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Light-Induced Click Reactions

(2013) Mehmet Atilla Tasdelen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation

(2013) Lourdes Castañeda et al.   CHEMICAL COMMUNICATIONS

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches

(2013) Wiktor Szymański et al.   CHEMICAL REVIEWS

Reversible protein affinity-labelling using bromomaleimide-based reagents

(2013) Ramiz I. Nathani et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence ‘turn-on’ reagents

(2013) Judith Youziel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

(2013) Lourdes Castañeda et al.   TETRAHEDRON LETTERS

Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’

(2013) Felix F. Schumacher et al.   Scientific Reports

Light-Controlled Tools

(2012) Clara Brieke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

[2 + 2] Photocycloadditions of thiomaleimides

(2012) Lauren M. Tedaldi et al.   CHEMICAL COMMUNICATIONS

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Azobenzene photoswitches for biomolecules

(2011) Andrew A. Beharry et al.   CHEMICAL SOCIETY REVIEWS

Decarboxylative photorelease coupled with fluorescent up/down reporter function based on the aminophthalimide–serine system

(2010) Alberto Soldevilla et al.   CHEMICAL COMMUNICATIONS

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

(2010) Mark E. B. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bromomaleimides: new reagents for the selective and reversible modification of cysteine

(2009) Lauren M. Tedaldi et al.   CHEMICAL COMMUNICATIONS

From somatostatin to octreotide LAR: evolution of a somatostatin analogue

(2009) Lowell Anthony et al.   CURRENT MEDICAL RESEARCH AND OPINION

Photochemical tools to study dynamic biological processes

(2009) Alexandre Specht et al.   HFSP Journal

Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates

(2008) Stephen C. Alley et al.   BIOCONJUGATE CHEMISTRY