Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

(2015) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates

(2015) Antoine Maruani et al.   CHEMICAL COMMUNICATIONS

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

(2015) João P. M. Nunes et al.   CHEMICAL COMMUNICATIONS

Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry

(2015) Samir Acherar et al.   CURRENT MEDICINAL CHEMISTRY

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

(2015) Rachel E. Morgan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

(2015) Patricia M. R. Pereira et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

(2015) Mark E. B. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment

(2014) Francesca Bryden et al.   BIOCONJUGATE CHEMISTRY

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

(2014) Felix F. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation

(2013) Lourdes Castañeda et al.   CHEMICAL COMMUNICATIONS

Maturing antibody–drug conjugate pipeline hits 30

(2013) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Antibody-Drug Conjugates for the Treatment of Cancer

(2012) John A. Flygare et al.   Chemical Biology & Drug Design

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unique Diagnostic and Therapeutic Roles of Porphyrins and Phthalocyanines in Photodynamic Therapy, Imaging and Theranostics

(2012) Leanne B. Josefsen et al.   Theranostics

Bromopyridazinedione-mediated protein and peptide bioconjugation

(2011) Vijay Chudasama et al.   CHEMICAL COMMUNICATIONS

Click chemistry: the emerging role of the azide-alkyne Huisgen dipolar addition in the preparation of substituted tetrapyrrolic derivatives

(2011) Fabienne Dumoulin et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Targeted photodynamic therapy – a promising strategy of tumor treatment

(2011) Andrzej M. Bugaj   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Photosensitiser–antibody conjugates for photodynamic therapy

(2011) Aaron J. Bullous et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

(2010) J. R. Junutula et al.   CLINICAL CANCER RESEARCH

Oncologic photodynamic therapy photosensitizers: A clinical review

(2010) Ron R. Allison et al.   Photodiagnosis and Photodynamic Therapy

Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies

(2009) Laurent Ducry et al.   BIOCONJUGATE CHEMISTRY

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY