A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis

Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

(2017) Jie Huang et al.   Cell and Bioscience

Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology

(2016) Gerald Ponath et al.   BRAIN

Acute axonal damage in three different murine models of multiple sclerosis: A comparative approach

(2016) Katharina Marie Höflich et al.   BRAIN RESEARCH

Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury

(2016) Thomas M. Reeves et al.   EXPERIMENTAL NEUROLOGY

Decreased Methylation Level of H3K27me3 Increases Seizure Susceptibility

(2016) Zhongcheng Wang et al.   MOLECULAR NEUROBIOLOGY

Distinctive role of KV1.1 subunit in the biology and functions of low threshold K+ channels with implications for neurological disease

(2016) Saak V. Ovsepian et al.   PHARMACOLOGY & THERAPEUTICS

Extensive acute axonal damage in pediatric multiple sclerosis lesions

(2015) Sabine Pfeifenbring et al.   ANNALS OF NEUROLOGY

Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo

(2015) Yohannes Haile et al.   Journal of Neuroinflammation

Treatment of progressive multiple sclerosis: what works, what does not, and what is needed

(2015) Anthony Feinstein et al.   LANCET NEUROLOGY

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties

(2015) Ning Zhao et al.   Scientific Reports

Development of dalfampridine, a novel pharmacologic approach for treating walking impairment in multiple sclerosis

(2014) Andrew R. Blight et al.   Annals of the New York Academy of Sciences

Neuroprotection in Multiple Sclerosis: A Therapeutic Approach

(2013) Amir-Hadi Maghzi et al.   CNS DRUGS

P2X4 receptors control the fate and survival of activated microglia

(2013) Nuria Vázquez-Villoldo et al.   GLIA

Oligodendrocyte Lineage and Subventricular Zone Response to Traumatic Axonal Injury in the Corpus Callosum

(2013) Genevieve M. Sullivan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neonatal Hyperoxia Exposure Disrupts Axon-Oligodendrocyte Integrity in the Subcortical White Matter

(2013) J. Ritter et al.   JOURNAL OF NEUROSCIENCE

Signaling through ERK1/2 Controls Myelin Thickness during Myelin Repair in the Adult Central Nervous System

(2013) S. L. Fyffe-Maricich et al.   JOURNAL OF NEUROSCIENCE

Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

(2013) Ying Peng et al.   NEURO-ONCOLOGY

Therapies for multiple sclerosis: translational achievements and outstanding needs

(2013) Aiden Haghikia et al.   TRENDS IN MOLECULAR MEDICINE

Neuroaxonal Regeneration is More Pronounced in Early Multiple Sclerosis than in Traumatic Brain Injury Lesions

(2012) Lucas Schirmer et al.   BRAIN PATHOLOGY

Association Between Use of Interferon Beta and Progression of Disability in Patients With Relapsing-Remitting Multiple Sclerosis

(2012) Afsaneh Shirani et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

C5b-9-activated, Kv1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation

(2011) Cosmin A. Tegla et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Critical appraisal of animal models of multiple sclerosis

(2011) David Baker et al.   Multiple Sclerosis Journal

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A highly sensitive electrochemiluminescence immunoassay for the neurofilament heavy chain protein

(2010) Jens Kuhle et al.   JOURNAL OF NEUROIMMUNOLOGY

ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion Isometrus maculates

(2010) Song Han et al.   TOXICON

Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivo

(2009) P D Koeberle et al.   CELL DEATH AND DIFFERENTIATION

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis

(2009) Srikant Rangaraju et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Focal adhesion kinase (FAK): A regulator of CNS myelination

(2009) Audrey D. Forrest et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A role for galanin in human and experimental inflammatory demyelination

(2009) D. C. Wraith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative multiplexed quantum dot immunohistochemistry

(2008) E. Sweeney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

(2008) Chris J. Hedegaard et al.   IMMUNOLOGY

Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease

(2008) Song Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Validation of a novel biomarker for acute axonal injury in experimental autoimmune encephalomyelitis

(2008) Melissa M. Gresle et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

(2008) Eva Herrero-Herranz et al.   NEUROBIOLOGY OF DISEASE