Matrix Stiffness and Colorectal Cancer

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts

(2018) Changwei Dou et al.   GASTROENTEROLOGY

Biomechanical and biomolecular characterization of extracellular matrix structures in human colon carcinomas

(2018) Eva Brauchle et al.   MATRIX BIOLOGY

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophage-mediated immunotherapy

(2018) Pengfei Zhao et al.   Chemical Science

Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells

(2018) Fengbo Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Genetic predisposition to colorectal cancer: syndromes, genes, classification of genetic variants and implications for precision medicine

(2018) Laura Valle et al.   JOURNAL OF PATHOLOGY

Biomarkers in colorectal cancer: Current clinical utility and future perspectives

(2018) Marco Vacante et al.   World Journal of Clinical Cases

Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor

(2017) Sanja Z Despotović et al.   TUMOR BIOLOGY

Extracellular matrix (ECM) activates β-catenin signaling in uterine fibroids

(2017) Yi-An Ko et al.   REPRODUCTION

Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases

(2016) Nancy Chan et al.   CLINICAL CANCER RESEARCH

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

(2016) N. N. Rahbari et al.   Science Translational Medicine

Changes in cellular mechanical properties during onset or progression of colorectal cancer

(2016) Gabriele Ciasca et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Spotlight on ixazomib: potential in the treatment of multiple myeloma

(2016) Abdel K. Azab et al.   Drug Design Development and Therapy

Extracellular matrix stiffness dictates Wnt expression through integrin pathway

(2016) Jing Du et al.   Scientific Reports

Metastatic Colorectal Cancer: Current State and Future Directions

(2015) Marwan G. Fakih   JOURNAL OF CLINICAL ONCOLOGY

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

(2015) María Elena Fernández-Sánchez et al.   NATURE

Mechanical and structural comparison between primary tumor and lymph node metastasis cells in colorectal cancer

(2015) V. Palmieri et al.   Soft Matter

p53mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation

(2015) Xiao-Lan Li   WORLD JOURNAL OF GASTROENTEROLOGY

Optimum 3D Matrix Stiffness for Maintenance of Cancer Stem Cells Is Dependent on Tissue Origin of Cancer Cells

(2015) Esmaiel Jabbari et al.   PLoS One

Targeting FAK in human cancer: from finding to first clinical trials

(2014) Vita Golubovskaya   Frontiers in Bioscience-Landmark

A mechanically-induced colon cancer cell population shows increased metastatic potential

(2014) Xin Tang et al.   Molecular Cancer

Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma

(2014) John C. Morris et al.   PLoS One

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice

(2013) Yunching Chen et al.   HEPATOLOGY

Matrix Stiffness Corresponding to Strictured Bowel Induces a Fibrogenic Response in Human Colonic Fibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases

(2013) Carl-Henrik Heldin   Journal of Neuroimmune Pharmacology

Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

(2013) Anna C. Luca et al.   PLoS One

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Growth-induced buckling of an epithelial layer

(2010) M. R. Nelson et al.   Biomechanics and Modeling in Mechanobiology

Mechanical Force Affects Expression of an In Vitro Metastasis-Like Phenotype in HCT-8 Cells

(2010) Xin Tang et al.   BIOPHYSICAL JOURNAL

Regulation of myofibroblast activities: Calcium pulls some strings behind the scene

(2010) Lysianne Follonier Castella et al.   EXPERIMENTAL CELL RESEARCH

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility

(2010) D Krndija et al.   ONCOGENE

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Differential expression of the LOX family genes in human colorectal adenocarcinomas

(2009) Kim   ONCOLOGY REPORTS

Mechanical factors activate ß‐catenin‐dependent oncogene expression in APC1638N/+ mouse colon

(2008) Joanne Whitehead et al.   HFSP Journal

Pleiotropic effects of statin therapy: molecular mechanisms and clinical results

(2008) Chao-Yung Wang et al.   TRENDS IN MOLECULAR MEDICINE