Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases

Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody

(2015) Juqun Shen et al.   NEOPLASIA

Autoantibodies against platelet-derived growth factor receptor alpha in patients with systemic lupus erythematosus

(2014) Kazuhiro Kurasawa et al.   Modern Rheumatology

Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension

(2013) Marius M. Hoeper et al.   CIRCULATION

Platelet-Derived Growth Factor C Deficiency in C57BL/6 Mice Leads to Abnormal Cerebral Vascularization, Loss of Neuroependymal Integrity, and Ventricular Abnormalities

(2012) Linda Fredriksson et al.   AMERICAN JOURNAL OF PATHOLOGY

Platelet-Derived Growth Factor (PDGF)-C Neutralization Reveals Differential Roles of PDGF Receptors in Liver and Kidney Fibrosis

(2012) Ina V. Martin et al.   AMERICAN JOURNAL OF PATHOLOGY

Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis

(2012) Britta Maurer et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of Src Tyrosine Kinases in Experimental Pulmonary Hypertension

(2012) Soni Savai Pullamsetti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet derived growth factor-CC isoform is associated with hemorrhagic transformation in ischemic stroke patients treated with tissue plasminogen activator

(2012) Raquel Rodríguez-González et al.   ATHEROSCLEROSIS

Effective Treatment of Edema and Endothelial Barrier Dysfunction With Imatinib

(2012) Jurjan Aman et al.   CIRCULATION

Adding to the Mix: Fibroblast Growth Factor and Platelet-Derived Growth Factor Receptor Pathways as Targets in Non – small Cell Lung Cancer

(2012) S. A. Kono et al.   CURRENT CANCER DRUG TARGETS

Targeting PDGF pathway in pulmonary arterial hypertension

(2012) Sabina Antonela Antoniu   EXPERT OPINION ON THERAPEUTIC TARGETS

Imatinib mesylate prevents cerebral vasospasm after subarachnoid hemorrhage via inhibiting tenascin-C expression in rats

(2012) Masato Shiba et al.   NEUROBIOLOGY OF DISEASE

Imatinib Enhances Functional Outcome after Spinal Cord Injury

(2012) Mathew B. Abrams et al.   PLoS One

The effects of sorafenib on the portal hypertensive syndrome in patients with liver cirrhosis and hepatocellular carcinoma - a pilot study

(2011) M. Pinter et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage

(2011) Qingyi Ma et al.   ANNALS OF NEUROLOGY

Imatinib mesylate (Gleevec) in the treatment of diffuse cutaneous systemic sclerosis: results of a 1-year, phase IIa, single-arm, open-label clinical trial

(2011) R. F. Spiera et al.   ANNALS OF THE RHEUMATIC DISEASES

Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor β in the skin of mice with scleroderma-like features and prevents the development of the disease

(2011) Niloufar Kavian et al.   ARTHRITIS AND RHEUMATISM

Angiogenic cytokines and growth factors in systemic sclerosis

(2011) Vasiliki Liakouli et al.   AUTOIMMUNITY REVIEWS

Epicardial-Derived Cell Epithelial-to-Mesenchymal Transition and Fate Specification Require PDGF Receptor Signaling

(2011) Christopher L. Smith et al.   CIRCULATION RESEARCH

PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development

(2011) Lorin E. Olson et al.   DEVELOPMENTAL CELL

Fully reversible pulmonary arterial hypertension associated with dasatinib treatment for chronic myeloid leukaemia

(2011) D. Dumitrescu et al.   EUROPEAN RESPIRATORY JOURNAL

Imatinib mesylate for the treatment of pulmonary arterial hypertension

(2011) Henrik ten Freyhaus et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A Phase I study of CR002, a fully-human monoclonal antibody against platelet-derived growth factor-D

(2011) T. Hawthorne et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib

(2011) Yuqing Liu et al.   JOURNAL OF HEPATOLOGY

Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D

(2011) Claudia R.C. van Roeyen et al.   KIDNEY INTERNATIONAL

Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis

(2011) Yi-Ting Chen et al.   KIDNEY INTERNATIONAL

Pathological Signaling via Platelet-Derived Growth Factor Receptor   Involves Chronic Activation of Akt and Suppression of p53

(2011) H. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis

(2011) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Case of Sclerodermatous Graft-versus-Host Disease Responsive to Imatinib Therapy

(2011) Jozef Lazar et al.   PEDIATRIC DERMATOLOGY

The PDGF family in renal fibrosis

(2011) Tammo Ostendorf et al.   PEDIATRIC NEPHROLOGY

Cognitive and Socio-Emotional Deficits in Platelet-Derived Growth Factor Receptor-β Gene Knockout Mice

(2011) Phuong Thi Hong Nguyen et al.   PLoS One

Morphine Induces Expression of Platelet-Derived Growth Factor in Human Brain Microvascular Endothelial Cells: Implication for Vascular Permeability

(2011) Hongxiu Wen et al.   PLoS One

Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611Cincreases PDGF-dependent vascular smooth muscle cell proliferation

(2011) Ali R. Keramati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Nilotinib on Bleomycin-Induced Acute Lung Injury and Pulmonary Fibrosis in Mice

(2011) Chin Kook Rhee et al.   RESPIRATION

Differential Properties of Current Tyrosine Kinase Inhibitors in Gastrointestinal Stromal Tumors

(2011) George D. Demetri   SEMINARS IN ONCOLOGY

Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension?

(2011) Jan K Hennigs et al.   BMC Pulmonary Medicine

Hypoxic Pulmonary Hypertension in Mice with Constitutively Active Platelet-Derived Growth Factor Receptor-β

(2011) Bhola K. Dahal et al.   Pulmonary Circulation

Imatinib in Pulmonary Arterial Hypertension Patients with Inadequate Response to Established Therapy

(2010) Hossein A. Ghofrani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by Down-Regulation of Protein Tyrosine Phosphatases

(2010) Henrik ten Freyhaus et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cocaine-mediated induction of platelet-derived growth factor: implication for increased vascular permeability

(2010) H. Yao et al.   BLOOD

A Novel Signaling Axis of Matriptase/PDGF-D/ -PDGFR in Human Prostate Cancer

(2010) C. V. Ustach et al.   CANCER RESEARCH

Targeting tyrosine kinases: a novel therapeutic strategy for systemic sclerosis

(2010) Jessica K Gordon et al.   CURRENT OPINION IN RHEUMATOLOGY

Platelet-derived growth factor receptor tyrosine kinase inhibitors: a review of the recent patent literature

(2010) Yujia Dai   EXPERT OPINION ON THERAPEUTIC PATENTS

Anti-PDGF-B monoclonal antibody reduces liver fibrosis development

(2010) Shinji Ogawa et al.   HEPATOLOGY RESEARCH

Platelet-derived Growth Factor-mediated Induction of the Synaptic Plasticity Gene Arc/Arg3.1

(2010) Fuwang Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

(2010) Yan Wang et al.   JOURNAL OF HEPATOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Nephrotoxicities Associated with the Use of Tyrosine Kinase Inhibitors: A Single-Center Experience and Review of the Literature

(2010) Kenar D. Jhaveri et al.   NEPHRON CLINICAL PRACTICE

Platelet-Derived Growth Factor-Induced Severe and Chronic Vasoconstriction of Cerebral Arteries

(2010) Zhi-Wen Zhang et al.   NEUROSURGERY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Imatinib Treatment for Idiopathic Pulmonary Fibrosis

(2009) Craig E. Daniels et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

What are the new milestones in the pathogenesis of systemic sclerosis?

(2009) N Hunzelmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor α in a subset of normal and systemic sclerosis patient sera

(2009) Nick Loizos et al.   ARTHRITIS AND RHEUMATISM

Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

(2009) Jean-François Classen et al.   ARTHRITIS AND RHEUMATISM

Molecular framework for response to imatinib mesylate in systemic sclerosis

(2009) Lorinda Chung et al.   ARTHRITIS AND RHEUMATISM

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis

(2009) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis

(2009) M Hennenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Significant improvement of right ventricular function by imatinib mesylate in scleroderma-associated pulmonary arterial hypertension

(2009) Henrik ten Freyhaus et al.   Clinical Research in Cardiology

Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy

(2009) Hetian Lei et al.   EXPERIMENTAL EYE RESEARCH

Cardiac mast cells cause atrial fibrillation through PDGF-A–mediated fibrosis in pressure-overloaded mouse hearts

(2009) Chien-hui Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Sorafenib attenuates the portal hypertensive syndrome in partial portal vein ligated rats

(2009) Thomas Reiberger et al.   JOURNAL OF HEPATOLOGY

Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model

(2009) Minglun Li et al.   Radiation Oncology

Acute Hepatitis in a Patient With Cirrhosis and Hepatocellular Carcinoma Treated With Sorafenib

(2008) Lucia Llanos et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Sorafenib-Induced Liver Failure

(2008)   AMERICAN JOURNAL OF GASTROENTEROLOGY

Imatinib in the Treatment of Nephrogenic Systemic Fibrosis

(2008) Sindhu Chandran et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension

(2008) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Anti-PDGFR-  antibodies measured by non-bioactivity assays are not specific for systemic sclerosis

(2008) E Balada et al.   ANNALS OF THE RHEUMATIC DISEASES

Is imatinib mesylate a promising drug in systemic sclerosis?

(2008) P. L. A. van Daele et al.   ARTHRITIS AND RHEUMATISM

Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease

(2008) Jörg H. W. Distler et al.   ARTHRITIS AND RHEUMATISM

Reversible dasatinib-induced pulmonary arterial hypertension and right ventricle failure in a previously allografted CML patient

(2008) D Mattei et al.   BONE MARROW TRANSPLANTATION

The Effect of Imatinib (Glivec®) on Scleroderma and Normal Dermal Fibroblasts: A Preclinical Study

(2008) A. Soria et al.   DERMATOLOGY

Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

(2008) Alfiya Akhmetshina et al.   FASEB JOURNAL

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Spontaneous hepatic fibrosis in transgenic mice overexpressing PDGF-A

(2008) Florian Thieringer et al.   GENE

Role of platelet-derived growth factors in physiology and medicine

(2008) J. Andrae et al.   GENES & DEVELOPMENT

Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

(2008) Marc Mejias et al.   HEPATOLOGY

PDGF-C Is a Proinflammatory Cytokine that Mediates Renal Interstitial Fibrosis

(2008) F. Eitner et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection

(2008) Liliana Soroceanu et al.   NATURE

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

(2008) Enming J Su et al.   NATURE MEDICINE

Imatinib for the treatment of refractory, diffuse systemic sclerosis

(2008) P. P. Sfikakis et al.   RHEUMATOLOGY

Enhanced Contractile Response of the Basilar Artery to Platelet-Derived Growth Factor in Subarachnoid Hemorrhage

(2008) Yoshihisa Maeda et al.   STROKE

A New Look at Platelet-Derived Growth Factor in Renal Disease

(2007) J. Floege et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY