Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri  3a

Burkholderia pseudomallei Capsular Polysaccharide Recognition by a Monoclonal Antibody Reveals Key Details toward a Biodefense Vaccine and Diagnostics against Melioidosis

(2015) Roberta Marchetti et al.   ACS Chemical Biology

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate

(2015) Stéphane Salamone et al.   CHEMICAL COMMUNICATIONS

Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics

(2015) Alberto Fernández-Tejada et al.   CHEMISTRY-A EUROPEAN JOURNAL

Shigella flexneri serotype 3a: the rise of a superbug

(2015) Hervé Agaisse   LANCET INFECTIOUS DISEASES

A synthetic strategy to xylose-containing thioglycoside tri- and tetrasaccharide building blocks corresponding to Cryptococcus neoformans capsular polysaccharide structures

(2015) Lorenzo Guazzelli et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Regioselective Benzylation of 2-Deoxy-2-aminosugars using Crown Ethers: Application to a Shortened Synthesis of Hyaluronic Acid Oligomers

(2014) Chinmoy Mukherjee et al.   ADVANCED SYNTHESIS & CATALYSIS

Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines

(2014) Chakkumkal Anish et al.   CHEMISTRY & BIOLOGY

Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development

(2014) S. Livio et al.   CLINICAL INFECTIOUS DISEASES

Linear synthesis of the branched pentasaccharide repeats of O-antigens from Shigella flexneri 1a and 1b demonstrating the major steric hindrance associated with type-specific glucosylation

(2014) Jason M. Hargreaves et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

(2014) Charles Gauthier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NMR and molecular recognition. The application of ligand-based NMR methods to monitor molecular interactions

(2014) Luca Unione et al.   MedChemComm

Early childhood diarrhoeal diseases and cognition: are we missing the rest of the iceberg?

(2014) Jessica MacIntyre et al.   Paediatrics and International Child Health

Total Synthesis of theEscherichia coliO111O-Specific Polysaccharide Repeating Unit

(2013) Oliviana Calin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural Studies of theO-Acetyl-Containing O-Antigen from aShigella flexneriSerotype 6 Strain and Synthesis of Oligo­saccharide Fragments Thereof

(2013) Pierre Chassagne et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Progress and pitfalls in Shigella vaccine research

(2013) Eileen M. Barry et al.   Nature Reviews Gastroenterology & Hepatology

Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation

(2013) Pierre Chassagne et al.   TETRAHEDRON

Synthetically defined glycoprotein vaccines: current status and future directions

(2013) Roberto Adamo et al.   Chemical Science

Shigella flexneriO-antigens revisited: final elucidation of the O-acetylation profiles and a survey of the O-antigen structure diversity

(2012) Andrei V. Perepelov et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Challenging Deprotection Steps During the Synthesis of Tetra- and Pentasaccharide Fragments of the LeaLex Tumor-Associated Hexasaccharide Antigen

(2012) Mickaël Guillemineau et al.   JOURNAL OF ORGANIC CHEMISTRY

Does Childhood Diarrhea Influence Cognition Beyond the Diarrhea-Stunting Pathway?

(2012) Christa L. Fischer Walker et al.   PLoS One

Carbohydrate-Protein Interactions: A 3D View by NMR

(2011) Virginia Roldós et al.   CHEMBIOCHEM

A Highly α-Stereoselective Synthesis of Oligosaccharide Fragments of the Vi Antigen from Salmonella typhi and Their Antigenic Activities

(2011) Lin Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation

(2011) Laura Morelli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance

(2011) François-Xavier Theillet et al.   GLYCOBIOLOGY

Application of NMR methods to the study of the interaction of natural products with biomolecular receptors

(2011) Luis P. Calle et al.   NATURAL PRODUCT REPORTS

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

Effects of backbone substitutions on the conformational behavior of Shigella flexneri O-antigens: implications for vaccine strategy

(2010) François-Xavier Theillet et al.   GLYCOBIOLOGY

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Age-related efficacy of Shigella O-specific polysaccharide conjugates in 1–4-year-old Israeli children

(2010) Justen H. Passwell et al.   VACCINE

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Shigella flexneri 2a Infection

(2009) A. Phalipon et al.   JOURNAL OF IMMUNOLOGY

Efficient Synthesis of Six Tri- to Hexasaccharide Fragments ofShigella flexneriSerotypes 3a and/or X O-Antigen, Including a Study on Acceptors ContainingN-Trichloroacetylglucosamine versusN-Acetylglucosamine

(2009) Julien Boutet et al.   JOURNAL OF ORGANIC CHEMISTRY

Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research

(2009) Thomas J. Boltje et al.   Nature Chemistry

Synthesis, characterization, and immunogenicity in mice of Shigella sonnei O-specific oligosaccharide-core-protein conjugates

(2009) J. B. Robbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of Two Tetra- and Four Pentasaccharide Fragments ofShigella flexneriSerotypes 3a and X O-Antigens from a Common Tetrasaccharide Intermediate

(2008) Julien Boutet et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Multi-country analysis of the effects of diarrhoea on childhood stunting

(2008) William Checkley et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody

(2008) B. Vulliez-Le Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of branched tri- to pentasaccharides representative of fragments of Shigella flexneri serotypes 3a and/or X O-antigens

(2008) Julien Boutet et al.   TETRAHEDRON

Efficient route to orthogonally protected precursors of 2-acylamino-2-deoxy-3-O-substituted-β-d-glucopyranose derivatives and use thereof

(2008) Julien Boutet et al.   TETRAHEDRON LETTERS

Innate Immune Responses of Synthetic Lipid A Derivatives ofNeisseria meningitidis

(2007) Yanghui Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL