Synthetically defined glycoprotein vaccines: current status and future directions

Protein Organic Chemistry and Applications for Labeling and Engineering in Live-Cell Systems

(2013) Yousuke Takaoka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Automated solid phase synthesis of oligoarabinofuranosides

(2013) Jeyakumar Kandasamy et al.   CHEMICAL COMMUNICATIONS

Rewriting the bacterial glycocalyx via Suzuki–Miyaura cross-coupling

(2013) Christopher D. Spicer et al.   CHEMICAL COMMUNICATIONS

The development of synthetic antitumour vaccines from mucin glycopeptide antigens

(2013) Nikola Gaidzik et al.   CHEMICAL SOCIETY REVIEWS

Thiol–yne radical reaction mediated site-specific protein labeling via genetic incorporation of an alkynyl-l-lysine analogue

(2013) Yiming Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phosphorylation of the Synthetic Hexasaccharide Repeating Unit Is Essential for the Induction of Antibodies to Clostridium difficile PSII Cell Wall Polysaccharide

(2012) Roberto Adamo et al.   ACS Chemical Biology

Automated Solid-Phase Synthesis of β-Mannuronic Acid Alginates

(2012) Marthe T. C. Walvoort et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Automated synthesis of sialylated oligosaccharides

(2012) Davide Esposito et al.   Beilstein Journal of Organic Chemistry

Prospects in the Total Synthesis of Protein Therapeutics

(2012) Justin M. Chalker   Chemical Biology & Drug Design

Metal complex catalysis in living biological systems

(2012) Pijus K. Sasmal et al.   CHEMICAL COMMUNICATIONS

Designing a new antifungal glycoconjugate vaccine

(2012) Margaret A. Johnson et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Chemical Synthesis and Immunological Evaluation of the Inner Core Oligosaccharide of Francisella tularensis

(2012) Thomas J. Boltje et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Assembly of Complex Oligosaccharides Using Anomeric Sulfonium Ions as Glycosyl Donors

(2012) Tao Fang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gold nanoparticles as carriers for a syntheticStreptococcus pneumoniaetype 14 conjugate vaccine

(2012) Dodi Safari et al.   Nanomedicine

HPLC-Assisted Automated Oligosaccharide Synthesis

(2012) N. Vijaya Ganesh et al.   ORGANIC LETTERS

Streamlined access to conjugation-ready glycans by automated synthesis

(2012) Lenz Kröck et al.   Chemical Science

A “Tag-and-Modify” Approach to Site-Selective Protein Modification

(2011) Justin M. Chalker et al.   ACCOUNTS OF CHEMICAL RESEARCH

Toward Automated Oligosaccharide Synthesis

(2011) Che-Hsiung Hsu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selenenylsulfide-Linked Homogeneous Glycopeptides and Glycoproteins: Synthesis of Human “Hepatic Se Metabolite A”

(2011) Omar Boutureira et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates

(2011) Elizabeth J. Grayson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations

(2011) Gonçalo J. L. Bernardes et al.   CHEMBIOCHEM

Direct radiolabelling of proteins at cysteine using [18F]-fluorosugars

(2011) Omar Boutureira et al.   CHEMICAL COMMUNICATIONS

Enzymes in the Synthesis of Glycoconjugates

(2011) Ryan M. Schmaltz et al.   CHEMICAL REVIEWS

A Possible Oligosaccharide-Conjugate Vaccine Candidate for Clostridium difficile Is Antigenic and Immunogenic

(2011) Matthias A. Oberli et al.   CHEMISTRY & BIOLOGY

Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation

(2011) Laura Morelli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

Efficacy of a Conjugate Vaccine Containing Polymannuronic Acid and Flagellin against Experimental Pseudomonas aeruginosa Lung Infection in Mice

(2011) Victoria L. Campodónico et al.   INFECTION AND IMMUNITY

Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag

(2011) Jason E. Hudak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

(2011) Jason S. McLellan et al.   NATURE

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

Peptide Ligations Accelerated byN-Terminal Aspartate and Glutamate Residues

(2011) Gemma L. Thomas et al.   ORGANIC LETTERS

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

(2011) V. Lakshminarayanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

(2011) R. Pejchal et al.   SCIENCE

Methods for converting cysteine to dehydroalanine on peptides and proteins

(2011) Justin M. Chalker et al.   Chemical Science

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Conjugation of SyntheticN-Acetyl-Lactosamine to Azide-Containing Proteins Using the Staudinger Ligation

(2010) Ravi S. Loka et al.   BIOCONJUGATE CHEMISTRY

Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins

(2010) Omar Boutureira et al.   CHEMICAL COMMUNICATIONS

Defining Criteria for Oligomannose Immunogens for HIV Using Icosahedral Virus Capsid Scaffolds

(2010) Rena D. Astronomo et al.   CHEMISTRY & BIOLOGY

NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines

(2010) Luis E. Fernandez et al.   Clinical & Developmental Immunology

Preparation, characterization and immunogenicity of HIV-1 related high-mannose oligosaccharides-CRM197 glycoconjugates

(2010) Anna Kabanova et al.   GLYCOCONJUGATE JOURNAL

Chemoenzymatic synthesis of differentially protected 3-deoxysugars

(2010) Dennis G. Gillingham et al.   Nature Chemistry

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity

(2010) K. J. Doores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carrier induced epitopic suppression of antibody responses induced by virus-like particles is a dynamic phenomenon caused by carrier-specific antibodies

(2010) Andrea Jegerlehner et al.   VACCINE

Glycoconjugate vaccines and immune interference: A review

(2010) Ron Dagan et al.   VACCINE

Site-selective chemoenzymatic construction of synthetic glycoproteins using endoglycosidases

(2010) Marta Fernández-González et al.   Chemical Science

Comparative bioinformatics analysis of the mammalian and bacterial glycomes

(2010) Alexander Adibekian et al.   Chemical Science

Combined Approaches to the Synthesis and Study of Glycoproteins

(2009) Gonçalo J. L. Bernardes et al.   ACS Chemical Biology

Thiyl Glycosylation of Olefinic Proteins: S-Linked Glycoconjugate Synthesis

(2009) Nicola Floyd et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How Bacterial Carbohydrates Influence the Adaptive Immune System

(2009) Fikri Y. Avci et al.   Annual Review of Immunology

Phosphate-assisted peptide ligation

(2009) Gemma L. Thomas et al.   CHEMICAL COMMUNICATIONS

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

(2009) Therese Buskas et al.   CHEMICAL COMMUNICATIONS

Enzymatic transglycosylation for glycoconjugate synthesis

(2009) Lai-Xi Wang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Antibodies against Man 1,2-Man 1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV strains

(2009) R. J Luallen et al.   GLYCOBIOLOGY

From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging methods for the production of homogeneous human glycoproteins

(2009) Jamie R Rich et al.   Nature Chemical Biology

Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research

(2009) Thomas J. Boltje et al.   Nature Chemistry

Rational design and immunogenicity of liposome-based diepitope constructs: Application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen

(2009) Fatouma Said Hassane et al.   VACCINE

Glycoprotein Synthesis: An Update

(2008) David P. Gamblin et al.   CHEMICAL REVIEWS

Automated Solid-Phase Synthesis of Protected Oligosaccharides Containing β-Mannosidic Linkages

(2008) Jeroen D. C. Codée et al.   CHEMISTRY-A EUROPEAN JOURNAL

Identification of the Smallest Structure Capable of Evoking Opsonophagocytic Antibodies against Streptococcus pneumoniae Type 14

(2008) D. Safari et al.   INFECTION AND IMMUNITY

Allyl Sulfides Are Privileged Substrates in Aqueous Cross-Metathesis: Application to Site-Selective Protein Modification

(2008) Yuya A. Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facile Conversion of Cysteine and Alkyl Cysteines to Dehydroalanine on Protein Surfaces: Versatile and Switchable Access to Functionalized Proteins

(2008) Gonçalo J. L. Bernardes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward solution-phase automated iterative synthesis: fluorous-tag assisted solution-phase synthesis of linear and branched mannose oligomers

(2008) Firoz A. Jaipuri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient Synthesis of an α(2,9) Trisialic Acid by One-Pot Glycosylation and Polymer-Assisted Deprotection

(2008) Hiroshi Tanaka et al.   ORGANIC LETTERS

An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions

(2008) J. G. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN

(2008) S.-K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic glycopeptide vaccines combining  -mannan and peptide epitopes induce protection against candidiasis

(2008) H. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA