Roles of G protein-coupled receptors in inflammatory bowel disease

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation

(2019) Irina V. Tcymbarevich et al.   BMC GASTROENTEROLOGY

Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer

(2019) Magdalena Grill et al.   Scientific Reports

Neuroimmune Interactions in the Gut and Their Significance for Intestinal Immunity

(2019) David J. Brinkman et al.   Cells

The influence of the brain–gut axis in inflammatory bowel disease and possible implications for treatment

(2019) David J Gracie et al.   Lancet Gastroenterology & Hepatology

Pharmacogenomics of GPCR Drug Targets

(2018) Alexander S. Hauser et al.   CELL

β-Blocker use is associated with a higher relapse risk of inflammatory bowel disease

(2018) Rose A. Willemze et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Bi-directionality of Brain–Gut Interactions in Patients With Inflammatory Bowel Disease

(2018) David J. Gracie et al.   GASTROENTEROLOGY

Cannabinoid Receptor 2 Functional Variant Contributes to the Risk for Pediatric Inflammatory Bowel Disease

(2018) Caterina Strisciuglio et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Molecular diagnosis and classification of inflammatory bowel disease

(2018) Hu Zhang et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Intestinal Activation of pH-Sensing Receptor OGR1 [GPR68] Contributes to Fibrogenesis

(2018) Senta Hutter et al.   Journal of Crohns & Colitis

Structure of the glucagon receptor in complex with a glucagon analogue

(2018) Haonan Zhang et al.   NATURE

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

(2018) R. Ferro et al.   ONCOGENE

Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease

(2018) Irina Tcymbarevich et al.   Journal of Crohns & Colitis

The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue

(2018) Katharina Kern et al.   Frontiers in Immunology

Localization of estrogen receptor ERα, ERβ and GPR30 on myenteric neurons of the gastrointestinal tract and their role in motility

(2018) Julia Y.H. Liu et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

The Proton-activated Receptor GPR4 Modulates Intestinal Inflammation

(2017) Yu Wang et al.   Journal of Crohns & Colitis

G protein-coupled receptor 30 (GPR30) expression pattern in inflammatory bowel disease patients suggests its key role in the inflammatory process. A preliminary study

(2017)   Journal of Gastrointestinal and Liver Diseases

Vagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease

(2017) B. Bonaz et al.   JOURNAL OF INTERNAL MEDICINE

Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

(2017) Catherine J. Hutchings et al.   NATURE REVIEWS DRUG DISCOVERY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

(2017) Peiwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein-coupled receptor 55 (GPR55) expresses differently in patients with Crohn’s disease and ulcerative colitis

(2017) Marcin Włodarczyk et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Role of autophagy in the pathogenesis of inflammatory bowel disease

(2017) Tomoya Iida et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract

(2017) Bruno Bonaz et al.   Frontiers in Immunology

Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines

(2016) Leon P. McLean et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms by which Stress Affects the Experimental and Clinical Inflammatory Bowel Disease (IBD): Role of Brain-Gut Axis

(2016) Bartosz Brzozowski et al.   Current Neuropharmacology

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

(2016) Kara G. Lassen et al.   IMMUNITY

3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management

(2016) Fernando Gomollón et al.   Journal of Crohns & Colitis

G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ

(2016) S. Courtney Frasch et al.   JOURNAL OF IMMUNOLOGY

Depression and anxiety in patients with Inflammatory Bowel Disease: A systematic review

(2016) Rachel Neuendorf et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Neuroimmunomodulation in the Gut: Focus on Inflammatory Bowel Disease

(2016) Claudio Bernardazzi et al.   MEDIATORS OF INFLAMMATION

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study

(2016) B. Bonaz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction

(2016) Hayato Fukuda et al.   ACS Medicinal Chemistry Letters

Cholinergic receptor activation on epithelia protects against cytokine-induced barrier dysfunction

(2015) S. Dhawan et al.   Acta Physiologica

Tumor Necrosis Factor α Decreases Glucagon-Like Peptide-2 Expression by Up-Regulating G-Protein–Coupled Receptor 120 in Crohn Disease

(2015) Takuya Tsukahara et al.   AMERICAN JOURNAL OF PATHOLOGY

The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment

(2015) Cheryl de Vallière et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Structural mechanism of G protein activation by G protein-coupled receptor

(2015) Nguyen Minh Duc et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium

(2015) Leon P. McLean et al.   INFLAMMATORY BOWEL DISEASES

Role of G Protein-coupled Orphan Receptors in Intestinal Inflammation

(2015) Andrzej Wasilewski et al.   INFLAMMATORY BOWEL DISEASES

G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation

(2015) Cheryl de Vallière et al.   INFLAMMATORY BOWEL DISEASES

Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERα36 and GPR30/GPER1

(2015) Vasiliki Pelekanou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The GPR55 antagonist CID16020046 protects against intestinal inflammation

(2015) A. Stančić et al.   NEUROGASTROENTEROLOGY AND MOTILITY

GPR55: From orphan to metabolic regulator?

(2015) Bo Liu et al.   PHARMACOLOGY & THERAPEUTICS

No association between the functional cannabinoid receptor type 2 Q63R variants and inflammatory bowel disease in Turkish subjects

(2015) Oya Yonal et al.   Turkish Journal of Gastroenterology

Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent

(2014) Francesca Borrelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabis Use Provides Symptom Relief in Patients with Inflammatory Bowel Disease but Is Associated with Worse Disease Prognosis in Patients with Crohnʼs Disease

(2014) Martin Storr et al.   INFLAMMATORY BOWEL DISEASES

Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

(2014) Estefanía Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adrenergic β2 Receptor Activation Stimulates Anti-Inflammatory Properties of Dendritic Cells In Vitro

(2014) Laurens E. Nijhuis et al.   PLoS One

Central Muscarinic Cholinergic Activation Alters Interaction between Splenic Dendritic Cell and CD4+CD25- T Cells in Experimental Colitis

(2014) Peris Munyaka et al.   PLoS One

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of inflammation by extracellular acidification and proton-sensing GPCRs

(2013) Fumikazu Okajima   CELLULAR SIGNALLING

Cannabis Induces a Clinical Response in Patients With Crohn's Disease: A Prospective Placebo-Controlled Study

(2013) Timna Naftali et al.   Clinical Gastroenterology and Hepatology

A potential role for GPR55 in the regulation of energy homeostasis

(2013) Anna C. Simcocks et al.   DRUG DISCOVERY TODAY

Emerging paradigms in GPCR allostery: implications for drug discovery

(2013) Denise Wootten et al.   NATURE REVIEWS DRUG DISCOVERY

Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis

(2013) Lixue Dong et al.   PLoS One

Current and future G protein-coupled receptor signaling targets for heart failure therapy

(2013) Anastasios Lymperopoulos et al.   Drug Design Development and Therapy

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors

(2013) Calvin R. Justus et al.   Frontiers in Physiology

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

(2012) Florian Rieder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Therapeutic Options for Transfusion Related Acute Lung Injury; the Potential of the G2A Receptor

(2012) Michael A. Ellison et al.   CURRENT PHARMACEUTICAL DESIGN

Oral contraceptives, reproductive factors and risk of inflammatory bowel disease

(2012) Hamed Khalili et al.   GUT

M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells

(2012) Md Rafiqul Islam Khan et al.   JOURNAL OF GASTROENTEROLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice

(2012) Kun Li et al.   PANCREAS

Off-Target Cannabinoid Effects Mediated by GPR55

(2012) Christopher M. Henstridge   PHARMACOLOGY

G-Protein Coupled Receptor 30 (GPR30): A Novel Regulator of Endothelial Inflammation

(2012) Subhadeep Chakrabarti et al.   PLoS One

Impact of Cannabis Treatment on the Quality of Life, Weight and Clinical Disease Activity in Inflammatory Bowel Disease Patients: A Pilot Prospective Study

(2011) Adi Lahat et al.   DIGESTION

Activation of T cell death-associated gene 8 attenuates inflammation by negatively regulating the function of inflammatory cells

(2011) Yoshiko Onozawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Macrophages from IBD patients exhibit defective tumour necrosis factor-α secretion but otherwise normal or augmented pro-inflammatory responses to infection

(2011) Nair Campos et al.   IMMUNOBIOLOGY

A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents

(2011) X.-H. Lin et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway

(2011) Aishe Chen et al.   PLoS One

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

(2011) P. Pacher et al.   PROGRESS IN LIPID RESEARCH

Extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells

(2010) Isao Ichimonji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment

(2010) Rudolf Schicho et al.   INFLAMMATORY BOWEL DISEASES

Localization of muscarinic receptors M1R, M2R and M3R in the human colon

(2010) A. M. Harrington et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK

(2010) C Andradas et al.   ONCOGENE

Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways

(2010) Jin-Peng Liu et al.   PHARMACOLOGICAL RESEARCH

Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages

(2009) C. Mogi et al.   JOURNAL OF IMMUNOLOGY

G2A and LPC: Regulatory functions in immunity

(2009) Janusz H. Kabarowski   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Hormonal Replacement Therapy After Menopause Is Protective of Disease Activity in Women With Inflammatory Bowel Disease

(2008) Sunanda V. Kane et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Risk of Oral Contraceptives in the Etiology of Inflammatory Bowel Disease: A Meta-Analysis

(2008) J.A. Cornish et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation

(2008) R H Straub et al.   GUT

The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

(2008) Penny C. Staton et al.   PAIN

Novel cannabinoid receptors

(2007) A J Brown   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

G2A Plays Proinflammatory Roles in Human Keratinocytes under Oxidative Stress as a Receptor for 9-Hydroxyoctadecadienoic Acid

(2007) Tomoyasu Hattori et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY