Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

The effect of oral honey and pollen on postoperative intraabdominal adhesions

(2016) Salih CELEPLI et al.   Turkish Journal of Gastroenterology

Functional Th1 Cells Are Required for Surgical Adhesion Formation in a Murine Model

(2014) A. O. Tzianabos et al.   JOURNAL OF IMMUNOLOGY

Smad, but not MAPK, pathway mediates the expression of type I collagen in radiation induced fibrosis

(2012) Hiroyuki Yano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model

(2012) M. Lalountas et al.   BRITISH JOURNAL OF SURGERY

Why study animal models of IBD?

(2012) Warren Strober   INFLAMMATORY BOWEL DISEASES

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Mucosal Healing and Fibrosis after Acute or Chronic Inflammation in Wild Type FVB-N Mice and C57BL6 Procollagen α1(I)-Promoter-GFP Reporter Mice

(2012) Shengli Ding et al.   PLoS One

Post-operative adhesions after digestive surgery: Their incidence and prevention: Review of the literature

(2012) M. Ouaïssi et al.   Journal of Visceral Surgery

Mast Cells Are an Essential Component of Human Radiation Proctitis and Contribute to Experimental Colorectal Damage in Mice

(2011) Karl Blirando et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation-Induced Endothelial-to-Mesenchymal Transition

(2011) Florian Rieder et al.   AMERICAN JOURNAL OF PATHOLOGY

Resveratrol causes cell cycle arrest, decreased collagen synthesis, and apoptosis in rat intestinal smooth muscle cells

(2011) Patricia Garcia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

β-catenin signaling

(2011) Anna P. Lam et al.   CURRENT OPINION IN RHEUMATOLOGY

Simvastatin Attenuates Intestinal Fibrosis Independent of the Anti-Inflammatory Effect by Promoting Fibroblast/Myofibroblast Apoptosis in the Regeneration/Healing Process from TNBS-Induced Colitis

(2011) Yosuke Abe et al.   DIGESTIVE DISEASES AND SCIENCES

The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis

(2011) Theresa C. Peterson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigenetic modifications: novel therapeutic strategies for systemic sclerosis?

(2011) Astrid Jüngel et al.   Expert Review of Clinical Immunology

Ultrasound Elasticity Imaging for Detecting Intestinal Fibrosis and Inflammation in Rats and Humans With Crohn's Disease

(2011) Ryan W. Stidham et al.   GASTROENTEROLOGY

Exploring anti-TGF-β therapies in cancer and fibrosis

(2011) Lukas J. A. C. Hawinkels et al.   GROWTH FACTORS

Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn's disease

(2011) L. Peyrin-Biroulet et al.   GUT

Pharmacological intervention studies using mouse models of the inflammatory bowel diseases

(2011) Iurii Koboziev et al.   INFLAMMATORY BOWEL DISEASES

Long-term outcome of treatment with infliximab in pediatric-onset Crohnʼs disease: A population-based study

(2011) Valérie Crombé et al.   INFLAMMATORY BOWEL DISEASES

Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: Impact of a “Top-Down” approach to intestinal fibrosis in mice

(2011) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

MicroRNAs in inflammatory bowel disease

(2011) Joel R. Pekow et al.   INFLAMMATORY BOWEL DISEASES

Resveratrol has antiinflammatory and antifibrotic effects in the peptidoglycan-polysaccharide rat model of Crohnʼs disease

(2011) Kinan Rahal et al.   INFLAMMATORY BOWEL DISEASES

Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis

(2011) Carlos Medina et al.   JOURNAL OF PATHOLOGY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn Disease

(2011) Jeremy Adler et al.   RADIOLOGY

Myofibroblasts and colonic anastomosis healing in Wistar rats

(2011) Christophoros Kosmidis et al.   BMC Surgery

Substance P Modulates Colitis-Asscociated Fibrosis

(2010) Hon Wai Koon et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of heat shock protein 47 in intestinal fibrosis of experimental colitis

(2010) Hiroshi Kitamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cross-Linked Hyaluronic Acid Films to Reduce Intra-Abdominal Postsurgical Adhesions in an Experimental Model

(2010) Christine A. Falabella et al.   DIGESTIVE SURGERY

Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine

(2010) Willemijn A. van Dop et al.   GASTROENTEROLOGY

Natural history of Crohn's disease in a population-based cohort from Cardiff (1986-2003): a study of changes in medical treatment and surgical resection rates

(2010) A. V. Ramadas et al.   GUT

Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep

(2010) Xu Yan et al.   INFLAMMATORY BOWEL DISEASES

Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/−) mice

(2010) Sunila Mahavadi et al.   INFLAMMATORY BOWEL DISEASES

Identification of Epithelial to Mesenchymal Transition as a Novel Source of Fibroblasts in Intestinal Fibrosis

(2010) Sarah N. Flier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Possible Involvement of the Transient Receptor Potential Vanilloid Type 1 Channel in Postoperative Adhesive Obstruction and Its Prevention by a Kampo (Traditional Japanese) Medicine, Daikenchuto

(2010) Yohei Tokita et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

(2010) Chris I.W. Lauder et al.   JOURNAL OF SURGICAL RESEARCH

Dietary arachidonic acid-mediated effects on colon inflammation using transcriptome analysis

(2010) Bianca Knoch et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pathogenetic mechanisms in radiation fibrosis

(2010) John Yarnold et al.   RADIOTHERAPY AND ONCOLOGY

Oral PEG 15–20 protects the intestine against radiation: role of lipid rafts

(2009) Vesta Valuckaite et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Molecular Aspects of Intestinal Radiation-Induced Fibrosis

(2009) Pascal Gervaz et al.   CURRENT MOLECULAR MEDICINE

A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora

(2009) R. J. Rigby et al.   GUT

Targeting TGF-β1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis

(2009) Yanbing Ma et al.   INFLAMMATORY BOWEL DISEASES

Animal models of multiple sclerosis for the development and validation of novel therapies – potential and limitations

(2009) Eilhard Mix et al.   JOURNAL OF NEUROLOGY

An Assessment of the Effects of a Hyaluronan-Based Solution on Reduction of Postsurgical Adhesion Formation in Rats: A Comparative Study of Hyaluronan-Based Solution and Two Film Barriers

(2009) Jun Seok Park et al.   JOURNAL OF SURGICAL RESEARCH

Intestinal fibrosis in IBD—a dynamic, multifactorial process

(2009) Florian Rieder et al.   Nature Reviews Gastroenterology & Hepatology

Animal models for the study of the developmental origins of health and disease

(2009) Sarah McMullen et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Animal Models of Epigenetic Inheritance

(2009) Philip Bocock et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-β1

(2008) Valérie Haydont et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis

(2008) Olga Martínez-Augustin et al.   BMC GENOMICS

Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene sulphonic acid

(2008) G. Latella et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

IL-13 Signaling via IL-13Rα2 Induces Major Downstream Fibrogenic Factors Mediating Fibrosis in Chronic TNBS Colitis

(2008) Stefan Fichtner–Feigl et al.   GASTROENTEROLOGY

Effects of Adalimumab Therapy on Incidence of Hospitalization and Surgery in Crohn's Disease: Results From the CHARM Study

(2008) Brian G. Feagan et al.   GASTROENTEROLOGY

Chronic Enteric Salmonella Infection in Mice Leads to Severe and Persistent Intestinal Fibrosis

(2008) Guntram A. Grassl et al.   GASTROENTEROLOGY

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

Natural History of Pediatric Crohn's Disease: A Population-Based Cohort Study

(2008) Gwenola Vernier–Massouille et al.   GASTROENTEROLOGY

Intestinal fibrosis in inflammatory bowel disease — Current knowledge and future perspectives

(2008) Florian Rieder et al.   Journal of Crohns & Colitis

Noninvasive Ultrasound Elasticity Imaging (UEI) of Crohn's Disease: Animal Model

(2008) Kang Kim et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY