An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani amastigotes
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani amastigotes
Authors
Keywords
-
Journal
Parasites & Vectors
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-04-16
DOI
10.1186/s13071-020-04064-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Quantitative secretome analysis unravels new secreted proteins in Amphotericin B resistant Leishmania donovani
- (2019) Gaurav Garg et al. Journal of Proteomics
- Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate
- (2019) Luz H. Patino et al. Parasites & Vectors
- Identifying miltefosine-resistant key genes in protein–protein interactions network and experimental verification in Iranian Leishmania major
- (2019) Niloofar Lari et al. MOLECULAR BIOLOGY REPORTS
- A new multi-epitope peptide vaccine induces immune responses and protection against Leishmania infantum in BALB/c mice
- (2019) Bahareh Vakili et al. MEDICAL MICROBIOLOGY AND IMMUNOLOGY
- Genome based screening of epitope ensemble vaccine candidates against dreadful visceral leishmaniasis using immunoinformatics approach
- (2019) Garima Singh et al. MICROBIAL PATHOGENESIS
- Vaccine candidates against leishmania under current research
- (2018) Salvador Iborra et al. Expert Review of Vaccines
- Structural vaccinology considerations for in silico designing of a multi-epitope vaccine
- (2018) Manica Negahdaripour et al. INFECTION GENETICS AND EVOLUTION
- Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis
- (2018) Toolika Singh et al. JOURNAL OF IMMUNOLOGY
- Leishmania donovani PP2C: Kinetics, structural attributes and in vitro immune response
- (2018) Pranay Jakkula et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Vaccination with a CD4 + and CD8 + T-cell epitopes-based recombinant chimeric protein derived from Leishmania infantum proteins confers protective immunity against visceral leishmaniasis
- (2018) Daniel S. Dias et al. Translational Research
- Reduced pathogenicity of fructose-1,6-bisphosphatase deficient Leishmania donovani and its use as an attenuated strain to induce protective immunogenicity
- (2018) Savita Saini et al. VACCINE
- Novel Immunoinformatics Approaches to Design Multi-epitope Subunit Vaccine for Malaria by Investigating Anopheles Salivary Protein
- (2018) Rajan Kumar Pandey et al. Scientific Reports
- Peptide Vaccines for Leishmaniasis
- (2018) Rory C. F. De Brito et al. Frontiers in Immunology
- Staphylococcus aureus Phenol-Soluble Modulins α1–α3 Act as Novel Toll-Like Receptor (TLR) 4 Antagonists to Inhibit HMGB1/TLR4/NF-κB Signaling Pathway
- (2018) Ming Chu et al. Frontiers in Immunology
- Immunoinformatics-aided design of a potential multi-epitope peptide vaccine against Leishmania infantum
- (2018) Bahareh Vakili et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Immuno-informatics Analysis to Identify Novel Vaccine Candidates and Design of a Multi-Epitope Based Vaccine Candidate Against Theileria parasites
- (2018) Prajna Parimita Kar et al. Frontiers in Immunology
- A vaccine composed of a hypothetical protein and the eukaryotic initiation factor 5a from Leishmania braziliensis cross-protection against Leishmania amazonensis infection
- (2017) Mariana Costa Duarte et al. IMMUNOBIOLOGY
- Mining the Proteome of Leishmania donovani for the Development of Novel MHC Class I Restricted Epitope for the Control of Visceral Leishmaniasis
- (2017) Manas R. Dikhit et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH
- (2017) Mohamed Osman et al. PLoS Neglected Tropical Diseases
- Towards elimination of visceral leishmaniasis in the Indian subcontinent—Translating research to practice to public health
- (2017) Siddhivinayak Hirve et al. PLoS Neglected Tropical Diseases
- Identification of Potential MHC Class-II-Restricted Epitopes Derived from Leishmania donovani Antigens by Reverse Vaccinology and Evaluation of Their CD4+ T-Cell Responsiveness against Visceral Leishmaniasis
- (2017) Manas Ranjan Dikhit et al. Frontiers in Immunology
- A Chimera Containing CD4+ and CD8+ T-Cell Epitopes of the Leishmania donovani Nucleoside Hydrolase (NH36) Optimizes Cross-Protection against Leishmania amazonesis Infection
- (2017) Marcus Vinícius Alves-Silva et al. Frontiers in Immunology
- Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential
- (2017) Gandharva Nagpal et al. Scientific Reports
- Exploring Leishmania secretory proteins to design B and T cell multi-epitope subunit vaccine using immunoinformatics approach
- (2017) Nazia Khatoon et al. Scientific Reports
- Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea
- (2016) Ryszard A. Zielke et al. MOLECULAR & CELLULAR PROTEOMICS
- A vaccine combining two Leishmania braziliensis proteins offers heterologous protection against Leishmania infantum infection
- (2016) Mariana C. Duarte et al. MOLECULAR IMMUNOLOGY
- Involvement of nucleoside diphosphate kinase b and elongation factor 2 in Leishmania braziliensis antimony resistance phenotype
- (2016) Douglas S. Moreira et al. Parasites & Vectors
- Strategic evaluation of vaccine candidate antigens for the prevention of Visceral Leishmaniasis
- (2016) Malcolm S. Duthie et al. VACCINE
- Identification of Immunoreactive Leishmania infantum Protein Antigens to Asymptomatic Dog Sera through Combined Immunoproteomics and Bioinformatics Analysis
- (2016) Maria Agallou et al. PLoS One
- Critical residues involved in Toll-like receptor 4 activation by cationic lipid nanocarriers are not located at the lipopolysaccharide-binding interface
- (2015) Caroline Lonez et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility
- (2015) Pietro Sormanni et al. JOURNAL OF MOLECULAR BIOLOGY
- The role of protein–protein interactions in Toll-like receptor function
- (2015) Nils A. Berglund et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Development of Leishmania vaccines in the era of visceral leishmaniasis elimination
- (2015) C. R. Engwerda et al. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
- Correction: Combining Cationic Liposomal Delivery with MPL-TDM for Cysteine Protease Cocktail Vaccination against Leishmania donovani: Evidence for Antigen Synergy and Protection
- (2015) Amrita Das et al. PLoS Neglected Tropical Diseases
- MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4
- (2015) Alja Oblak et al. PLoS One
- AllerTOP v.2—a server for in silico prediction of allergens
- (2014) Ivan Dimitrov et al. JOURNAL OF MOLECULAR MODELING
- An experimental protocol for the establishment of dogs with long-term cellular immune reactions to Leishmania antigens
- (2014) Márcia Cristina Aquino Teixeira et al. MEMORIAS DO INSTITUTO OSWALDO CRUZ
- Experimental Validation of Multi-Epitope Peptides Including Promising MHC Class I- and II-Restricted Epitopes of Four Known Leishmania infantum Proteins
- (2014) Maria Agallou et al. Frontiers in Immunology
- The superfamily of mitochondrial Complex1_LYR motif-containing (LYRM) proteins
- (2013) Heike Angerer BIOCHEMICAL SOCIETY TRANSACTIONS
- Designing of interferon-gamma inducing MHC class-II binders
- (2013) Sandeep Kumar Dhanda et al. Biology Direct
- HLA Class I Alleles Are Associated with Peptide-Binding Repertoires of Different Size, Affinity, and Immunogenicity
- (2013) S. Paul et al. JOURNAL OF IMMUNOLOGY
- Proteome changes associated with Leishmania donovani promastigote adaptation to oxidative and nitrosative stresses
- (2013) Abul Hasan Sardar et al. Journal of Proteomics
- In silico Analysis and Experimental Validation ofMycobacterium tuberculosis-Specific Proteins and Peptides ofMycobacterium tuberculosisfor Immunological Diagnosis and Vaccine Development
- (2013) Abu Salim Mustafa MEDICAL PRINCIPLES AND PRACTICE
- GalaxyRefine: protein structure refinement driven by side-chain repacking
- (2013) Lim Heo et al. NUCLEIC ACIDS RESEARCH
- Cathepsin B Gene Disruption Induced Leishmania donovani Proteome Remodeling Implies Cathepsin B Role in Secretome Regulation
- (2013) Teklu Kuru Gerbaba et al. PLoS One
- Developing vaccines in the era of genomics: a decade of reverse vaccinology
- (2012) K.L. Seib et al. CLINICAL MICROBIOLOGY AND INFECTION
- Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives
- (2012) Ana Paula Fernandes et al. CURRENT OPINION IN MICROBIOLOGY
- Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I
- (2012) Umeharu Ohto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synthetic Toll Like Receptor-4 (TLR-4) Agonist Peptides as a Novel Class of Adjuvants
- (2012) Arulkumaran Shanmugam et al. PLoS One
- Evaluation of Leishmania donovani Protein Disulfide Isomerase as a Potential Immunogenic Protein/Vaccine Candidate against Visceral Leishmaniasis
- (2012) Pramod Kumar Kushawaha et al. PLoS One
- Immunogenicity and immune modulatory effects of in silico predictedL. donovanicandidate peptide vaccines
- (2012) Mona E.E. Elfaki et al. Human Vaccines & Immunotherapeutics
- Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation
- (2011) Pascale Pescher et al. CELLULAR MICROBIOLOGY
- Visceral leishmaniasis: immunology and prospects for a vaccine
- (2011) P.M. Kaye et al. CLINICAL MICROBIOLOGY AND INFECTION
- Elongation Factor-2, a Th1 Stimulatory Protein of Leishmania donovani, Generates Strong IFN- and IL-12 Response in Cured Leishmania-Infected Patients/Hamsters and Protects Hamsters against Leishmania Challenge
- (2011) P. K. Kushawaha et al. JOURNAL OF IMMUNOLOGY
- SignalP 4.0: discriminating signal peptides from transmembrane regions
- (2011) Thomas Nordahl Petersen et al. NATURE METHODS
- Mitochondrial Associated Ubiquitin Fold Modifier-1 Mediated Protein Conjugation in Leishmania donovani
- (2011) Sreenivas Gannavaram et al. PLoS One
- A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine for use in the prevention of visceral leishmaniasis
- (2011) Jaya Chakravarty et al. VACCINE
- High-throughput prediction of protein antigenicity using protein microarray data
- (2010) Christophe N. Magnan et al. BIOINFORMATICS
- Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress
- (2010) Camila S. Ramos et al. EXPERIMENTAL PARASITOLOGY
- Evaluation of DNA/DNA and prime-boost vaccination using LPG3 against Leishmania major infection in susceptible BALB/c mice and its antigenic properties in human leishmaniasis
- (2010) Narges Abdian et al. EXPERIMENTAL PARASITOLOGY
- Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists
- (2010) Matthew Black et al. Expert Review of Vaccines
- Multiple levels of gene regulation mediate differentiation of the intracellular pathogen Leishmania
- (2010) T. Lahav et al. FASEB JOURNAL
- IFN- Receptor Signaling Regulates Memory CD8+ T Cell Differentiation
- (2010) O. Sercan et al. JOURNAL OF IMMUNOLOGY
- Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel
- (2010) Marc Schmidt et al. NATURE IMMUNOLOGY
- Computational Immunology Meets Bioinformatics: The Use of Prediction Tools for Molecular Binding in the Simulation of the Immune System
- (2010) Nicolas Rapin et al. PLoS One
- Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage
- (2010) M. A. Morales et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Vaccination Route That Induces Transforming Growth Factor Production Fails To Elicit Protective Immunity against Leishmania donovani Infection
- (2009) S. Bhowmick et al. INFECTION AND IMMUNITY
- Identification and Characterization of a Novel Deoxyhypusine Synthase inLeishmania donovani
- (2009) Bhavna Chawla et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8
- (2009) Elmar Krieger et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- ElliPro: a new structure-based tool for the prediction of antibody epitopes
- (2008) Julia Ponomarenko et al. BMC BIOINFORMATICS
- I-TASSER server for protein 3D structure prediction
- (2008) Yang Zhang BMC BIOINFORMATICS
- Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
- (2008) Fatma Z Guerfali et al. BMC GENOMICS
- Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species
- (2008) Annie Rochette et al. BMC GENOMICS
- gp63 in Stable Cationic Liposomes Confers Sustained Vaccine Immunity to Susceptible BALB/c Mice Infected with Leishmania donovani
- (2008) S. Bhowmick et al. INFECTION AND IMMUNITY
- Predicting linear B‐cell epitopes using string kernels
- (2008) Yasser EL‐Manzalawy et al. JOURNAL OF MOLECULAR RECOGNITION
- Immunogenicity of HSP-70, KMP-11 and PFR-2 leishmanial antigens in the experimental model of canine visceral leishmaniasis
- (2008) Eugenia Carrillo et al. VACCINE
- Cysteine proteinase type III is protective against Leishmania infantum infection in BALB/c mice and highly antigenic in visceral leishmaniasis individuals
- (2008) Naghmeh Khoshgoo et al. VACCINE
- Proteomic analysis of the secretome of Leishmania donovani
- (2008) J Maxwell Silverman et al. GENOME BIOLOGY
- Retooling Leishmania metabolism: from sand fly gut to human macrophage
- (2007) Doron Rosenzweig et al. FASEB JOURNAL
- Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages
- (2007) Bala Krishna Kolli et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More