Critical residues involved in Toll-like receptor 4 activation by cationic lipid nanocarriers are not located at the lipopolysaccharide-binding interface

MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4

(2015) Alja Oblak et al.   PLoS One

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa

(2014) C. Walsh et al.   JOURNAL OF IMMUNOLOGY

Identification of Key Residues That Confer Rhodobacter sphaeroides LPS Activity at Horse TLR4/MD-2

(2014) Katherine L. Irvine et al.   PLoS One

Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages

(2013) Guangbo Qu et al.   ACS Nano

Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles

(2013) Sharmy Mano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liposomal Lipopolysaccharide Initiates TRIF-Dependent Signaling Pathway Independent of CD14

(2013) Sachiko Watanabe et al.   PLoS One

Cationic lipids activate intracellular signaling pathways

(2012) Caroline Lonez et al.   ADVANCED DRUG DELIVERY REVIEWS

Temperature-Dependence of Cationic Lipid Bilayer Intermixing: Possible Role of Interdigitation

(2012) Tiago R. Oliveira et al.   LANGMUIR

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice, men and the relatives: cross-species studies underpin innate immunity

(2012) C. E. Bryant et al.   Open Biology

Effects of Differences in Lipid A Structure on TLR4 Pro-Inflammatory Signaling and Inflammasome Activation

(2012) Paula M. Chilton et al.   Frontiers in Immunology

The induction of innate and adaptive immunity by biodegradable poly(γ-glutamic acid) nanoparticles via a TLR4 and MyD88 signaling pathway

(2011) Tomofumi Uto et al.   BIOMATERIALS

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

From agonist to antagonist: Structure and dynamics of innate immune glycoprotein MD-2 upon recognition of variably acylated bacterial endotoxins

(2011) Mari L. DeMarco et al.   MOLECULAR IMMUNOLOGY

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

(2010) Ranit Kedmi et al.   BIOMATERIALS

Deciphering the complexity of Toll-like receptor signaling

(2010) Renato Ostuni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MD-2 Residues Tyrosine 42, Arginine 69, Aspartic Acid 122, and Leucine 125 Provide Species Specificity for Lipid IVA

(2010) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Cationic lipids activate cellular cascades. Which receptors are involved?

(2009) Caroline Lonez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Fusogenic activity of cationic lipids and lipid shape distribution

(2009) Caroline Lonez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CD14-independent responses induced by a synthetic lipid A mimetic

(2009) Amandine Legat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation

(2009) Jianmin Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

DiC14-amidine cationic liposomes stimulate myeloid dendritic cells through Toll-like receptor 4

(2008) Tetsuya Tanaka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Cationic liposomal lipids: From gene carriers to cell signaling

(2008) Caroline Lonez et al.   PROGRESS IN LIPID RESEARCH