Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

A paradigm for peptide vaccine delivery using viral epitopes encapsulated in degradable polymer hydrogel capsules

(2009) Siow-Feng Chong et al.   BIOMATERIALS

The path to a successful vaccine adjuvant – ‘The long and winding road’

(2009) Derek T. O’Hagan et al.   DRUG DISCOVERY TODAY

MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3

(2009) E. F. Kenny et al.   JOURNAL OF IMMUNOLOGY

A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge

(2009) X Zhang et al.   Mucosal Immunology

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation

(2009) R. Belizaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting atherosclerosis by using modular, multifunctional micelles

(2009) D. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Phase 1 study of the blood-stage malaria vaccine candidate AMA1-C1/Alhydrogel® with CPG 7909, using two different formulations and dosing intervals

(2009) Ruth D. Ellis et al.   VACCINE

Liposome-encapsulated HIV-1 Gag p24 containing lipid A induces effector CD4+ T-cells, memory CD8+ T-cells, and pro-inflammatory cytokines

(2009) Nicholas J. Steers et al.   VACCINE

ISCOMs and ISCOMATRIX™

(2009) Hong-Xiang Sun et al.   VACCINE

Eleven years of Inflexal® V—a virosomal adjuvanted influenza vaccine

(2009) Christian Herzog et al.   VACCINE

Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice

(2009) Satoshi Ohno et al.   VACCINE

Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research

(2008) Hong Lin et al.   BMC BIOINFORMATICS

Evaluation of MHC class I peptide binding prediction servers: Applications for vaccine research

(2008) Hong Lin et al.   BMC IMMUNOLOGY

Central role of dendritic cells in the regulation and deregulation of immune responses

(2008) F. Granucci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Self-Adjuvanting Lipopeptide Vaccines

(2008) Peter Moyle et al.   CURRENT MEDICINAL CHEMISTRY

Virus-sized vaccine delivery systems

(2008) J SCHEERLINCK et al.   DRUG DISCOVERY TODAY

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

(2008) Luke A.J. O'Neill   IMMUNITY

Vaccine Adjuvants Alter TCR-Based Selection Thresholds

(2008) Laurent Malherbe et al.   IMMUNITY

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

Vaccine adjuvant systems: Enhancing the efficacy of sub-unit protein antigens

(2008) Yvonne Perrie et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Poly(I:C) coated PLGA microparticles induce dendritic cell maturation

(2008) C WISCHKE et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

(2008) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emerging role of Toll-like receptors in atherosclerosis

(2008) Linda K. Curtiss et al.   JOURNAL OF LIPID RESEARCH

Glycopeptide dendrimers, Part III—a review: Use of glycopeptide dendrimers in immunotherapy and diagnosis of cancer and viral diseases

(2008) Petr Niederhafner et al.   JOURNAL OF PEPTIDE SCIENCE

Incorporation of Membrane-Anchored Flagellin into Influenza Virus-Like Particles Enhances the Breadth of Immune Responses

(2008) B.-Z. Wang et al.   JOURNAL OF VIROLOGY

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY

Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides

(2008) Jennifer M. Dan et al.   PLoS One

The TLR3 signaling complex forms by cooperative receptor dimerization

(2008) J. N. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines

(2008) Q. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cationic liposomal lipids: From gene carriers to cell signaling

(2008) Caroline Lonez et al.   PROGRESS IN LIPID RESEARCH

Synergistic effects of chemical insult and toll-like receptor ligands on dendritic cell activation

(2008) Rebecca J. Dearman et al.   TOXICOLOGY IN VITRO

Vaccination against foot-and-mouth disease virus using peptides conjugated to nano-beads

(2008) Deanne L.V. Greenwood et al.   VACCINE

A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection

(2008) Brendon Y. Chua et al.   VACCINE

Incorporation of LpxL1, a detoxified lipopolysaccharide adjuvant, in influenza H5N1 virosomes increases vaccine immunogenicity

(2008) J.J.C. de Vries et al.   VACCINE

Efficient peritoneal dissemination treatment obtained by an immunostimulatory phosphorothioate-type CpG DNA/cationic liposome complex in mice

(2007) Yukari Kuramoto et al.   JOURNAL OF CONTROLLED RELEASE

Nano/micro technologies for delivering macromolecular therapeutics using poly(d,l-lactide-co-glycolide) and its derivatives

(2007) Raghavendra C. Mundargi et al.   JOURNAL OF CONTROLLED RELEASE

Structure–Activity Relationship of a Series of Synthetic Lipopeptide Self-Adjuvanting Group A Streptococcal Vaccine Candidates

(2007) Abu-Baker M. Abdel-Aal et al.   JOURNAL OF MEDICINAL CHEMISTRY