Estrogen Signaling in Alzheimer’s Disease: Molecular Insights and Therapeutic Targets for Alzheimer’s Dementia

Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration

(2020) Md. Ataur Rahman et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   MOLECULES

Exploring the Promise of Targeting Ubiquitin-Proteasome System to Combat Alzheimer’s Disease

(2020) Abdullah Al Mamun et al.   NEUROTOXICITY RESEARCH

Circadian and sleep dysfunction in Alzheimer’s disease

(2020) Md. Sahab Uddin et al.   AGEING RESEARCH REVIEWS

ApoE4: an emerging therapeutic target for Alzheimer’s disease

(2019) Mirna Safieh et al.   BMC Medicine

Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis

(2018) Md. Sahab Uddin et al.   MOLECULAR NEUROBIOLOGY

Short-term Hormone Therapy with Transdermal Estradiol Improves Cognition for Postmenopausal Women with Alzheimer's Disease: Results of a Randomized Controlled Trial

(2018) Whitney Wharton et al.   JOURNAL OF ALZHEIMERS DISEASE

New Evidence of Mitochondria Dysfunction in the Female Alzheimer's Disease Brain: Deficiency of Estrogen Receptor-β

(2018) Jiangang Long et al.   JOURNAL OF ALZHEIMERS DISEASE

Update on the Neuroprotective Effect of Estrogen Receptor Alpha Against Alzheimer's Disease

(2018) Yu-Long Lan et al.   JOURNAL OF ALZHEIMERS DISEASE

Analyzing the chance of developing dementia among geriatric people: a cross-sectional pilot study in Bangladesh

(2018) Md. Sahab Uddin et al.   Psychogeriatrics

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis

(2018) Md. Sahab Uddin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Apolipoprotein E gene polymorphism modifies fasting total cholesterol concentrations in response to replacement of dietary saturated with monounsaturated fatty acids in adults at moderate cardiovascular disease risk

(2017) Israa M. Shatwan et al.   Lipids in Health and Disease

Estrogen-Related Factors in the Frontal Lobe of Alzheimer’s Disease Patients and Importance of Body Mass Index

(2017) Naoko Honma et al.   Scientific Reports

ERβ and ApoE isoforms interact to regulate BDNF–5-HT2A signaling and synaptic function in the female brain

(2017) Anindit Chhibber et al.   Alzheimers Research & Therapy

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

(2017) Sandra Zárate et al.   Frontiers in Aging Neuroscience

Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline

(2017) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Therapies for Prevention and Treatment of Alzheimer’s Disease

(2016) J. Mendiola-Precoma et al.   Biomed Research International

Estrogen receptor β in Alzheimer’s disease: From mechanisms to therapeutics

(2015) Liqin Zhao et al.   AGEING RESEARCH REVIEWS

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Diverse Molecular Targets for Therapeutic Strategies in Alzheimer's Disease

(2014) Sun-Ho Han et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons

(2014) Nirut Suwanna et al.   NEUROSCIENCE LETTERS

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease

(2013) Yu-Ling Chang et al.   Alzheimers & Dementia

Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

(2013) Leo Ungar et al.   Brain Imaging and Behavior

Alzheimer's disease: Review of hormone therapy trials and implications for treatment and prevention after menopause

(2013) Victor W. Henderson   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeting Estrogen Receptors for the Treatment of Alzheimer’s Disease

(2013) Jung Hoon Lee et al.   MOLECULAR NEUROBIOLOGY

Involvement of IGF-I receptor and estrogen receptor pathways in the protective effects of ginsenoside Rg1 against Aβ25–35-induced toxicity in PC12 cells

(2013) Wen-Fang Chen et al.   NEUROCHEMISTRY INTERNATIONAL

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen synthesis and signaling pathways during aging: from periphery to brain

(2013) Jie Cui et al.   TRENDS IN MOLECULAR MEDICINE

Oestrogen receptor polymorphisms are an associated risk factor for mild cognitive impairment and Alzheimer disease in women APOE ɛ4 carriers: a case–control study

(2013) Manuel Fernández-Martínez et al.   BMJ Open

Plasma ghrelin levels are closely associated with severity and morphology of angiographically-detected coronary atherosclerosis in Chineses patients with diabetes mellitus

(2012) Min Zhang et al.   ACTA PHARMACOLOGICA SINICA

Effects of Food and Drug Administration-approved medications for Alzheimer’s disease on clinical progression

(2012) Michelle M. Mielke et al.   Alzheimers & Dementia

Role of estrogen receptor-α (ESR1) and the type 1 insulin-like growth factor receptor (IGFR1) in estradiol-stimulated proliferation of cultured bovine satellite cells

(2012) E. Kamanga-Sollo et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Daxx is a key downstream component of receptor interacting protein kinase 3 mediating retinal ischemic cell death

(2012) Yun-Suk Lee et al.   FEBS LETTERS

Oestrogen receptor α agonist improved long-term ovariectomy-induced spatial cognition deficit in young rats

(2012) Na Qu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

GPR30 Regulates Glutamate Transporter GLT-1 Expression in Rat Primary Astrocytes

(2012) Eunsook Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Greater cognitive deterioration in women than men with Alzheimer's disease: A meta analysis

(2012) Karen Irvine et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research

(2012) Christine L. Carter et al.   JOURNAL OF WOMENS HEALTH

Estrogens and memory in physiological and neuropathological conditions

(2012) Assunta Pompili et al.   PSYCHONEUROENDOCRINOLOGY

Death Domain-associated Protein (DAXX)-mediated Regulation of Transcription and Cell Death

(2012) Ryuta Muromoto   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

National estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Ron Brookmeyer et al.   Alzheimers & Dementia

Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging

(2011) Thomas C. Foster   HIPPOCAMPUS

Estrogen receptors stimulate brain region specific metabotropic glutamate receptors to rapidly initiate signal transduction pathways

(2011) John Meitzen et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Women have Farther to Fall: Gender Differences Between Normal Elderly and Alzheimer's Disease in Verbal Memory Engender Better Detection of Alzheimer's Disease in Women

(2011) Robert M. Chapman et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson’s disease

(2011) Thomas Müller et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Structural brain changes in normal individuals with a maternal history of Alzheimer's

(2011) Valentina Berti et al.   NEUROBIOLOGY OF AGING

Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease

(2011) R. A. Honea et al.   NEUROLOGY

Estrogen protects against amyloid-β toxicity by estrogen receptor α-mediated inhibition of Daxx translocation

(2011) Laura Mateos et al.   NEUROSCIENCE LETTERS

C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-  and the critical period hypothesis of estrogen neuroprotection

(2011) Q.-g. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The critical period hypothesis of estrogen effects on cognition: Insights from basic research

(2010) Jill M. Daniel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Entacapone and Tolcapone, Two CatecholO-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity

(2010) Saviana Di Giovanni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent anion channel as a resident protein of lipid rafts: post-transductional regulation by estrogens and involvement in neuronal preservation against Alzheimer’s disease

(2010) Jose Luis Herrera et al.   JOURNAL OF NEUROCHEMISTRY

Ligand-Independent Antiapoptotic Function of Estrogen Receptor-β in Lung Cancer Cells

(2010) GuangFeng Zhang et al.   MOLECULAR ENDOCRINOLOGY

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Effect of entacapone on plasma homocysteine levels in Parkinson’s disease patients

(2010) Martin Nevrly et al.   NEUROLOGICAL SCIENCES

Roles of estrogen receptors alpha and beta in sexually dimorphic neuroprotection against glutamate toxicity

(2010) D.N. Bryant et al.   NEUROSCIENCE

Loss of estrogen receptor β decreases mitochondrial energetic potential and increases thrombogenicity of platelets in aged female mice

(2009) Muthuvel Jayachandran et al.   AGE

Tolcapone Effects on Gating, Working Memory, and Mood Interact with the Synonymous Catechol-O-methyltransferase rs4818C/G Polymorphism

(2009) Panos Roussos et al.   BIOLOGICAL PSYCHIATRY

Identification of a Membrane Estrogen Receptor in Zebrafish with Homology to Mammalian GPER and Its High Expression in Early Germ Cells of the Testis1

(2009) Xiaochun Liu et al.   BIOLOGY OF REPRODUCTION

The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers

(2009) Manuel Martínez et al.   BMC NEUROSCIENCE

Estrogen Attenuates Ischemic Oxidative Damage via an Estrogen Receptor  -Mediated Inhibition of NADPH Oxidase Activation

(2009) Q.-G. Zhang et al.   JOURNAL OF NEUROSCIENCE

VDAC and ERα interaction in caveolae from human cortex is altered in Alzheimer's disease

(2009) Cristina M. Ramírez et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Neuroprotective effects of R,R-tetrahydrochrysene against glutamate-induced cell death through anti-excitotoxic and antioxidant actions involving estrogen receptor–dependent and –independent pathways

(2009) Y. Xia et al.   NEUROSCIENCE

Oxidative stress increases levels of endogenous amyloid-β peptides secreted from primary chick brain neurons

(2008) Claire Goldsbury et al.   AGING CELL

Role of wild-type estrogen receptor-β in mitochondrial cytoprotection of cultured normal male and female human lens epithelial cells

(2008) J. M. Flynn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Amyloid β -Protein Assembly as a Therapeutic Target of Alzheimers Disease

(2008) Ghiam Yamin et al.   CURRENT PHARMACEUTICAL DESIGN

Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17β- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells

(2008) E. Kamanga-Sollo et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Potential role of G-protein-coupled receptor 30 (GPR30) in estradiol-17β-stimulated IGF-I mRNA expression in bovine satellite cell cultures

(2008) E. Kamanga-Sollo et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Seladin-1 Is a Fundamental Mediator of the Neuroprotective Effects of Estrogen in Human Neuroblast Long-Term Cell Cultures

(2008) Paola Luciani et al.   ENDOCRINOLOGY

Role of Dickkopf-1, an Antagonist of the Wnt/ -Catenin Signaling Pathway, in Estrogen-Induced Neuroprotection and Attenuation of Tau Phosphorylation

(2008) Q.-G. Zhang et al.   JOURNAL OF NEUROSCIENCE

Estrogen synthesis in the brain—Role in synaptic plasticity and memory

(2008) Yasushi Hojo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of estrogen receptor-β regulates hippocampal synaptic plasticity and improves memory

(2008) Feng Liu et al.   NATURE NEUROSCIENCE

Improvement of Prepulse Inhibition and Executive Function by the COMT Inhibitor Tolcapone Depends on COMT Val158Met Polymorphism

(2008) Stella G Giakoumaki et al.   NEUROPSYCHOPHARMACOLOGY

Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex

(2008) C. C. Lapish et al.   PSYCHOPHARMACOLOGY

Estrogens and progesterone as neuroprotectants: what animal models teach us

(2007) Meharvan Singh   Frontiers in Bioscience-Landmark