Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism

(2019) Gisela Geoghegan et al.   Molecular Metabolism

SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferation

(2019) Vivien Freihen et al.   INTERNATIONAL JOURNAL OF CANCER

Genome-wide mapping of DNA-binding sites identifies stemness-related genes as directly repressed targets of SNAIL1 in colorectal cancer cells

(2019) Sven Beyes et al.   ONCOGENE

TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer

(2018) Jinfeng Xiang et al.   Cell Death & Disease

Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis

(2018) Felix Bormann et al.   Cell Reports

Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells

(2018) Dusan Hrckulak et al.   Genes

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

(2017) Kaja C. G. Berg et al.   Molecular Cancer

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells

(2017) Sabine Jägle et al.   PLoS Genetics

Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing

(2016) Oskar Schnappauf et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-92a Promotes Colorectal Cancer Cell Growth and Migration by Inhibiting KLF4

(2016) Huiqing Lv et al.   ONCOLOGY RESEARCH

A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate

(2016) Antonis Giakountis et al.   Cell Reports

Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells

(2016) Caroline Theresa Seebauer et al.   OncoImmunology

TCF/LEF Transcription Factors: An Update from the Internet Resources

(2016) Dusan Hrckulak et al.   Cancers

Rapid Reversible Photoswitching of Integrin-Mediated Adhesion at the Single-Cell Level

(2015) Laith F. Kadem et al.   ADVANCED MATERIALS

ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGF  Signaling Pathway

(2015) X.-Q. Li et al.   CANCER RESEARCH

Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

(2015) Jurian Schuijers et al.   Cell Stem Cell

A versatile modular vector system for rapid combinatorial mammalian genetics

(2015) Joachim Albers et al.   JOURNAL OF CLINICAL INVESTIGATION

Fitting Linear Mixed-Effects Models Usinglme4

(2015) Douglas Bates et al.   Journal of Statistical Software

Standardizing chromatin research: a simple and universal method for ChIP-seq

(2015) Laura Arrigoni et al.   NUCLEIC ACIDS RESEARCH

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

(2014) D. Mouradov et al.   CANCER RESEARCH

SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer

(2014) Kerstin Rönsch et al.   Molecular Oncology

The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition

(2014) Nate P. Hoverter et al.   NUCLEIC ACIDS RESEARCH

Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer

(2014) Sabine Jägle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4

(2013) W Tang et al.   BRITISH JOURNAL OF CANCER

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

(2013) Anguraj Sadanandam et al.   NATURE MEDICINE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer

(2012) Yong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal

(2012) J. H. van Es et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

TCF/LEFs and Wnt Signaling in the Nucleus

(2012) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3

(2012) Seth Frietze et al.   GENOME BIOLOGY

Integrin  7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion

(2011) P. Neri et al.   BLOOD

Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

(2011) Felipe de Sousa E Melo et al.   Cell Stem Cell

Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing ofCDX1andEPHBtumor suppressor genes in colorectal cancer

(2011) Kerstin Rönsch et al.   Epigenetics

Multiple Wnt/ß-Catenin Responsive Enhancers Align with the MYC Promoter through Long-Range Chromatin Loops

(2011) Gregory S. Yochum   PLoS One

T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

(2011) M. L. Angus-Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

(2010) Frédéric Varnat et al.   EMBO Molecular Medicine

An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase

(2010) Andrea Kranz et al.   GENESIS

Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles

(2010) Michal Mokry et al.   PLoS One

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

(2009) Sari Tuupanen et al.   NATURE GENETICS

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

(2009) V. Rodilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Screen for  -Catenin Binding Sites Identifies a Downstream Enhancer Element That Controls c-Myc Gene Expression

(2008) G. S. Yochum et al.   MOLECULAR AND CELLULAR BIOLOGY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

A genome-wide RNAi screen for Wnt/ -catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

(2008) W. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA