Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders

Oral glutathione administration inhibits the oxidative stress and the inflammatory responses in AppNL−G-F/NL−G-F knock-in mice

(2020) Hisanao Izumi et al.   NEUROPHARMACOLOGY

Cognitive Improvement with Glutathione Supplement in Alzheimer’s Disease: A Way Forward

(2019) Pravat K. Mandal et al.   JOURNAL OF ALZHEIMERS DISEASE

Editorial: Predictive Imagable Biomarkers for Neurodegenerative and Neurodevelopmental Diseases

(2019) Pravat K. Mandal et al.   Frontiers in Neurology

Quantitation of in vivo brain glutathione conformers in cingulate cortex among age‐matched control, MCI, and AD patients using MEGA‐PRESS

(2019) Deepika Shukla et al.   HUMAN BRAIN MAPPING

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

(2019) Ankita Nandi et al.   Oxidative Medicine and Cellular Longevity

Redox Signaling, Neuroinflammation, and Neurodegeneration

(2018) Gabriela Aguilera et al.   ANTIOXIDANTS & REDOX SIGNALING

Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI

(2018) Shankar Tumati et al.   Frontiers in Aging Neuroscience

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

The Emerging Role of Glutathione in Alzheimer's Disease

(2018) Sumiti Saharan et al.   JOURNAL OF ALZHEIMERS DISEASE

A Multi-Center Human Brain Glutathione Conformation Study from Magnetic Resonance Spectroscopy

(2018) Deepika Shukla et al.   JOURNAL OF ALZHEIMERS DISEASE

Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

(2018) Giuseppe Tardiolo et al.   MOLECULES

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

(2017) R Sinha et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders

(2017) Beihui Liu et al.   GLIA

Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy

(2017) Pravat K. Mandal et al.   JOURNAL OF ALZHEIMERS DISEASE

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

(2017) Hoi-Shan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress

(2017) Lisa D. Coles et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Phase IIb Study of Intranasal Glutathione in Parkinson’s Disease

(2017) Laurie K. Mischley et al.   Journal of Parkinsons Disease

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathionists in the battlefield of gamma-glutamyl cycle

(2016) Masayasu Inoue   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Transient glutathione depletion in the substantia nigra compacta is associated with neuroinflammation in rats

(2016) Mei-Li Díaz-Hung et al.   NEUROSCIENCE

A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder

(2016) Logan K. Wink et al.   Molecular Autism

A Short Review on the Current Understanding of Autism Spectrum Disorders

(2016) Hye Ran Park et al.   Experimental Neurobiology

The roles of glutaredoxins ligating Fe–S clusters: Sensing, transfer or repair functions?

(2015) Jérémy Couturier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease

(2015) Pravat K. Mandal et al.   BIOLOGICAL PSYCHIATRY

Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study.

(2015) Bernard Schmitt et al.   Redox Biology

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione

(2014) John P. Richie et al.   EUROPEAN JOURNAL OF NUTRITION

In Vitro and ex Vivo Uptake of Glutathione (GSH) across the Intestinal Epithelium and Fate of Oral GSH after in Vivo Supplementation

(2014) Jennifer Kovacs-Nolan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1)

(2013) Koji Aoyama et al.   AMINO ACIDS

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Energy metabolism and glutamate-glutamine cycle in the brain: a stoichiometric modeling perspective

(2013) Francesco A Massucci et al.   BMC Systems Biology

Glutathione-complexed iron–sulfur clusters. Reaction intermediates and evidence for a template effect promoting assembly and stability

(2013) Wenbin Qi et al.   CHEMICAL COMMUNICATIONS

N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases

(2013) Mary J. Holmay et al.   CLINICAL NEUROPHARMACOLOGY

Efficient nitrosation of glutathione by nitric oxide

(2013) Bernd Kolesnik et al.   FREE RADICAL BIOLOGY AND MEDICINE

A clinical trial of glutathione supplementation in autism spectrum disorders

(2013) Janet K. Kern et al.   MEDICAL SCIENCE MONITOR

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reduced Glutathione: A Radioprotector or a Modulator of DNA-Repair Activity?

(2013) Anupam Chatterjee   Nutrients

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells

(2012) Enrico Desideri et al.   Autophagy

Mitochondrial glutathione: Features, regulation and role in disease

(2012) Montserrat Marí et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism

(2012) Antonio Y. Hardan et al.   BIOLOGICAL PSYCHIATRY

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis

(2012) Kalavathi Dasuri et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Ascorbate-glutathione-α-tocopherol Triad in Abiotic Stress Response

(2012) András Szarka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease

(2012) Sönke Arlt et al.   NEUROCHEMICAL RESEARCH

Modern methods for delivery of drugs across the blood–brain barrier

(2011) Yan Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Brain oxidative stress: Detection and mapping of anti-oxidant marker ‘Glutathione’ in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy

(2011) Pravat K. Mandal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control

(2011) Chitranshu Kumar et al.   EMBO JOURNAL

Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers

(2011) Jason Allen et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Different Behaviors of Glutathione in Aqueous and DMSO Solutions: Molecular Dynamics Simulation and NMR Experimental Study

(2011) Rong Zhang et al.   JOURNAL OF SOLUTION CHEMISTRY

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Edith Lubos et al.   ANTIOXIDANTS & REDOX SIGNALING

p38MAPK/p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration

(2010) Simone Cardaci et al.   BIOCHEMICAL JOURNAL

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Cadmium - glutathione solution structures provide new insights into heavy metal detoxification

(2010) Olivier Delalande et al.   FEBS Journal

The use of thiols by ribonucleotide reductase

(2010) Arne Holmgren et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

(2010) Jeremy W. Gawryluk et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Glutathione as an oral whitening agent: A randomized, double-blind, placebo-controlled study

(2010) Nutthavuth Arjinpathana et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T

(2010) I-Y Choi et al.   Multiple Sclerosis Journal

Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze

(2009) F.E. Harrison et al.   BEHAVIOURAL BRAIN RESEARCH

Reaction between nitric oxide, glutathione, and oxygen in the presence and absence of protein: How are S-nitrosothiols formed?

(2009) Agnes Keszler et al.   FREE RADICAL BIOLOGY AND MEDICINE

MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis

(2009) Radhika Srinivasan et al.   MAGNETIC RESONANCE IMAGING

Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease

(2009) Robert A. Hauser et al.   MOVEMENT DISORDERS

Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation

(2009) Carin Thomas et al.   REDOX REPORT

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The production of reactive oxygen species by complex I

(2008) Judy Hirst et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of Neuronal Glutathione Synthesis

(2008) Koji Aoyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Intramuscular injections: a review of best practice for mental health nurses

(2008) A. COCOMAN et al.   Journal of Psychiatric and Mental Health Nursing

Protein Levels and Activity of Some Antioxidant Enzymes in Hippocampus of Subjects with Amnestic Mild Cognitive Impairment

(2008) Rukhsana Sultana et al.   NEUROCHEMICAL RESEARCH

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study

(2008) Daisuke Matsuzawa et al.   PLoS One