Editorial Material
Neurosciences
Alan J. Lerner
Summary: Non-invasive tests for detecting cerebral amyloidosis and Alzheimer's disease are being introduced in clinical care. However, there is a need for careful consideration of how to use and communicate the results, as well as the potential unintended consequences of biomarker tests.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Chieh-Hsin Lin, Hsien-Yuan Lane
Summary: This study longitudinally monitored plasma GSH levels and cognitive function in MCI patients, showing a significant decline over a 2-year period, while these levels remained relatively stable in healthy individuals. Both baseline GSH levels and changes in GSH levels were found to significantly influence cognitive decline in MCI patients, suggesting that blood GSH concentration may be a potential biomarker for monitoring cognitive changes in MCI.
Article
Neurosciences
Heather Sandison, Nini G. L. Callan, Rammohan V. Rao, John Phipps, Ryan Bradley
Summary: This study aimed to investigate the effect of a multimodal, individualized care plan based on potential contributors to cognitive decline on cognitive function in individuals with OCI. The results showed that multiple measures of cognitive function improved after six months of intervention.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Rulin Geng, Yu Zhang, Miao Liu, Shengfeng Deng, Jingwen Ding, Hongfei Zhong, Qiuyun Tu
Summary: This study investigated the relationship between serum uric acid and cognitive function in older adults, finding a significant positive correlation between the two. Age also significantly influenced the association between serum uric acid and cognitive function. These findings support a link between serum uric acid and cognition, suggesting that a slight increase within the normal range may enhance cognitive ability.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Paloma Bermejo-Bescos, Karim L. Jimenez-Aliaga, Juana Benedi, Sagrario Martin-Aragon
Summary: This study aimed to explore the effects of quercetin and rutin on the intracellular redox homeostasis, BACE1 activity, and APP expression in AD mice. The results showed that both quercetin and rutin could improve the antioxidant capacity, reduce lipid peroxidation, and downregulate the expression of APP and BACE1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Mehnaz Ahmed, Nathan Herrmann, Jinghan Jenny Chen, Mahwesh Saleem, Paul Oh, Ana C. Andreazza, Alexander Kiss, Krista L. Lanctot
Summary: The study found that GPX was elevated in VCIND patients as a compensatory response to persistent oxidative stress. Increased GPX in VCIND patients was associated with poorer cognitive outcomes, especially verbal memory.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rao Song, Xiaojia Wu, Huan Liu, Dajing Guo, Lin Tang, Wei Zhang, Junbang Feng, Chuanming Li
Summary: This study improved the N biomarker in individuals with mild cognitive impairment (MCI) using radiomics, and demonstrated its value in predicting cognitive progression. Additionally, the study clarified the predictive value of single A/T/N biomarkers for MCI cognitive progression.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xue-Yan Huang, Lu-Lu Xue, Ting-Bao Chen, Li-Ren Huangfu, Ting-Hua Wang, Liu-Lin Xiong, Chang-Yin Yu
Summary: Currently, the treatment of Alzheimer's disease (AD) is symptomatic due to lack of effective drugs. Miracle fruit seeds (MFSs) have been studied for their lipid-lowering and antidiabetic effects, but their therapeutic effects in AD have not been reported. This study aimed to provide data resources and a potential drug for AD treatment. MFSs were found to improve learning memory function and increase surviving neurons in an AD mouse model. Furthermore, network pharmacological approaches and molecular docking studies identified key targets and implicated the insulin signaling pathway and the Wnt pathway in the therapeutic effects of MFSs on AD. These findings offer potential possibilities and drug candidates for AD treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Polymer Science
Ravi Gangalla, Sampath Gattu, Sivasankar Palaniappan, Maqusood Ahamed, Baswaraju Macha, Raja Komuraiah Thampu, Antonella Fais, Alberto Cincotti, Gianluca Gatto, Murali Dama, Amit Kumar
Summary: The study isolated Bacillus amyloliquefaciens RK3 from a contaminated soil, which was then used to generate a potential polysaccharide with anti-Alzheimer's activity. The purified polysaccharide significantly impacted plaques formed by amyloid proteins during Alzheimer's disease, indicating its potential for various industrial and pharmaceutical applications.
Article
Geriatrics & Gerontology
Aladdin H. Shadyab, Linda K. McEvoy, Steve Horvath, Eric A. Whitsel, Stephen R. Rapp, Mark A. Espeland, Susan M. Resnick, JoAnn E. Manson, Jiu-Chiuan Chen, Brian H. Chen, Wenjun Li, Kathleen M. Hayden, Wei Bao, Cynthia D. J. Kusters, Andrea Z. LaCroix
Summary: The study examined the association between epigenetic age acceleration and cognitive impairment, finding that intrinsic AgeAccel was not significantly associated with cognitive impairment overall, but was associated with impairment among women who developed coronary heart disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Scott Ayton, Stuart Portbury, Pawel Kalinowski, Puja Agarwal, Ibrahima Diouf, Julie A. Schneider, Martha Clare Morris, Ashley I. Bush
Summary: This paper proposes an updated version of the iron hypothesis in Alzheimer's disease, suggesting that brain iron levels are associated with disease progression and may play a role in neurodegeneration. Further research is needed to validate the hypothesis.
ALZHEIMERS & DEMENTIA
(2021)
Article
Biochemistry & Molecular Biology
Zhibin Liang, Pamela Maher
Summary: Alzheimer's disease is a common age-associated disease with no effective treatments. Using phenotypic screening assays, Sterubin from Yerba Santa was identified as a potential drug candidate for AD treatment. Sterubin exhibits neuroprotective and anti-inflammatory effects, and can prevent memory decline.
Article
Cell Biology
Magdalena Mroczek, Christopher Clark, Loic Dayon, Gene L. Bowman, Julius Popp
Summary: This study identified cerebrospinal fluid proteome alterations associated with neuropsychiatric symptoms (NPS). These alterations are related to the pathophysiology of Alzheimer's disease (AD) and cognitive decline, and may represent independent processes from AD. Furthermore, some of these protein changes were found to be associated with accelerated cognitive decline.
Article
Health Care Sciences & Services
Caterina Formica, Lilla Bonanno, Fabio Mauro Giambo, Giuseppa Maresca, Desiree Latella, Angela Marra, Fabio Cucinotta, Carmen Bonanno, Marco Lombardo, Orazio Tomarchio, Angelo Quartarone, Silvia Marino, Rocco Salvatore Calabro, Viviana Lo Buono
Summary: Alzheimer's disease is the most common form of neurodegenerative disorder and its prodromal phase is mild cognitive impairment. The use of artificial intelligence for diagnostic and predictive analysis in neurodegenerative disorders is challenging. This study proposes a Machine Learning Model trained on a dataset of clinical and neuropsychological data to predict cognitive decline in MCI and AD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
Sangjoon Lee, Tae Kyoo Kim, Ji Eun Choi, Yunjung Choi, Minsu You, Jeewon Ryu, Yoo Lim Chun, Suji Ham, Seung Jae Hyeon, Hoon Ryu, Hye-Sun Kim, Heh-In Im
Summary: The dysregulation of MeCP2-mediated epigenome in the striatum is linked to defects in cognitive behavior and neuronal activity in an AD animal model, even in the early stages of AD pathogenesis. MeCP2 may serve as a potential target for the diagnosis and treatment of AD at both asymptomatic and symptomatic stages.
