Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer’s Disease

The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders

(2019) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma

(2019) Fatima Bilal et al.   Frontiers in Pharmacology

The Intra-nuclear SphK2-S1P Axis Facilitates M1-to-M2 Shift of Microglia via Suppressing HDAC1-Mediated KLF4 Deacetylation

(2019) Juan Ji et al.   Frontiers in Immunology

A Pilot Microbiota Study in Parkinson’s Disease Patients versus Control Subjects, and Effects of FTY720 and FTY720-Mitoxy Therapies in Parkinsonian and Multiple System Atrophy Mouse Models

(2019) Guadalupe Vidal-Martinez et al.   Journal of Parkinsons Disease

Fingolimod (FTY720) improves the functional recovery and myelin preservation of the optic pathway in focal demyelination model of rat optic chiasm

(2019) Mona Hashemian et al.   BRAIN RESEARCH BULLETIN

Age-Dependent Changes to Sphingolipid Balance in the Human Hippocampus are Gender-Specific and May Sensitize to Neurodegeneration

(2018) Timothy A. Couttas et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease

(2018) Henryk Jęśko et al.   MOLECULAR NEUROBIOLOGY

Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase

(2018) Joanna Motyl et al.   NEUROPHARMACOLOGY

Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements

(2018) Mariangela Sociale et al.   Cell Reports

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

(2018) Vijay R. Varma et al.   PLOS MEDICINE

Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway

(2018) Panpan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Glial Activation in AβPP/PS1 Mice is Associated with Infiltration of IFNγ-Producing Cells

(2018) Ronan J. Kelly et al.   JOURNAL OF ALZHEIMERS DISEASE

The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration

(2018) Henryk Jęśko et al.   MOLECULAR NEUROBIOLOGY

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

(2018) Nigel Turner et al.   Nature Communications

Fingolimod enhances myelin repair of hippocampus in pentylenetetrazol-induced kindling model

(2017) Mohammad Gol et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation

(2017) Róisín M. McManus et al.   Journal of Neuroimmune Pharmacology

Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-κB pathways in activated microglia in cerebral ischemia reperfusion

(2017) Danying Su et al.   JOURNAL OF NEUROIMMUNOLOGY

Clinical characterization of an APP mutation (V717I) in five Han Chinese families with early-onset Alzheimer's disease

(2017) Guili Zhang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Alzheimer Disease

(2017) Richard J. Caselli et al.   MAYO CLINIC PROCEEDINGS

FTY720 (Fingolimod) reverses α-synuclein-induced downregulation of brain-derived neurotrophic factor mRNA in OLN-93 oligodendroglial cells

(2017) Ismael Segura-Ulate et al.   NEUROPHARMACOLOGY

Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens

(2017) Kareem R. Rumah et al.   Frontiers in Cellular and Infection Microbiology

Drug Repositioning for Alzheimer’s Disease Based on Systematic ‘omics’ Data Mining

(2017) Ming Zhang et al.   PLoS One

The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration

(2016) Sofia Anastasiadou et al.   EXPERIMENTAL NEUROLOGY

Effects of fingolimod administration in a genetic model of cognitive deficits

(2016) D. Becker-Krail et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing

(2016) Scott Bidlingmaier et al.   MOLECULAR & CELLULAR PROTEOMICS

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Rosa Luisa Potenza et al.   Neurotherapeutics

Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway

(2016) Sizhao Lu et al.   PLoS One

Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer’s disease

(2016) Nurgul Aytan et al.   Scientific Reports

Growth factor treatment to overcome Alzheimer's dysfunctional signaling

(2015) Marc-Antoine Lauzon et al.   CELLULAR SIGNALLING

The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis

(2015) Samuel F. Hunter et al.   CNS DRUGS

Progressive inflammatory pathology in the retina of aluminum-fed 5xFAD transgenic mice

(2015) AI Pogue et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Fingolimod induces neuroprotective factors in human astrocytes

(2015) Franziska S. Hoffmann et al.   Journal of Neuroinflammation

Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and AβAccumulation

(2015) Maja Jazvinšćak Jembrek et al.   Oxidative Medicine and Cellular Longevity

Sphingolipid Metabolism Correlates with Cerebrospinal Fluid Beta Amyloid Levels in Alzheimer’s Disease

(2015) Alfred N. Fonteh et al.   PLoS One

Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation

(2015) Io-Guané Rivera et al.   Toxins

The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer

(2015) N C Hait et al.   Oncogenesis

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

(2014) Kazuya Fukumoto et al.   BEHAVIOURAL BRAIN RESEARCH

Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells

(2014) Marthe-Susanna Wegner et al.   BIOCHEMICAL PHARMACOLOGY

Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells

(2014) Gauri A. Patwardhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

Sphingosine-1-Phosphate Mediates COX-2 Expression and PGE2/IL-6 Secretion via c-Src-Dependent AP-1 Activation

(2014) Chih-Kai Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of S1P1 Receptor Regulates PI3K/Akt/FoxO3a Pathway in Response to Oxidative Stress in PC12 Cells

(2014) Fatemeh Safarian et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Testing Aβ toxicity on primary CNS cultures using drug-screening microfluidic chips

(2014) A. Ruiz et al.   LAB ON A CHIP

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

Fingolimod for the treatment of neurological diseases—state of play and future perspectives

(2014) Robert Brunkhorst et al.   Frontiers in Cellular Neuroscience

Animal models of Alzheimer disease: historical pitfalls and a path forward

(2014) Sarah E. Cavanaugh   ALTEX-Alternatives to Animal Experimentation

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

(2014) Timothy A Couttas et al.   Acta Neuropathologica Communications

Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with Memantine

(2013) Fatemeh Hemmati et al.   BEHAVIOURAL BRAIN RESEARCH

Ceramide and the mitochondrial respiratory chain

(2013) Aviram Kogot-Levin et al.   BIOCHIMIE

AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose

(2013) Kaipeng Huang et al.   CELLULAR SIGNALLING

Ablation of Ceramide Synthase 2 Causes Chronic Oxidative Stress Due to Disruption of the Mitochondrial Respiratory Chain

(2013) Hila Zigdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

(2012) Ruben van Doorn et al.   ACTA NEUROPATHOLOGICA

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism

(2011) N Hagen et al.   CELL DEATH AND DIFFERENTIATION

NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells

(2011) Walter J. Lukiw   EXPERIMENTAL NEUROLOGY

Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease

(2010) Xianlin Han   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease

(2010) Jian Guo Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory, Apoptotic, and Survival Gene Signaling in Alzheimer’s Disease

(2010) Walter J. Lukiw et al.   MOLECULAR NEUROBIOLOGY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING