Article
Oncology
Won Gun Kwack, Ji-Youn Sung, Seung Hyeun Lee
Summary: High Romo1 expression is associated with poor response to EGFR-TKIs treatment and shorter survival in lung adenocarcinoma patients. It indicates the need for active surveillance and tailored therapeutic approach for this subgroup. Additionally, Romo1 may serve as a potential predictive and prognostic biomarker for this patient population.
FRONTIERS IN ONCOLOGY
(2021)
Article
Fisheries
W. M. Gayashani Sandamalika, H. M. V. Udayantha, D. S. Liyanage, Chaehyeon Lim, Gaeun Kim, Hyukjae Kwon, Jehee Lee
Summary: In this study, the Romo1 homolog from the black rockfish was identified and characterized. The results showed that SsRomo1 plays an important role in immune response and tissue homeostasis.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jie Liu, Chuan Xia, Huixue Dong, Pan Liu, Ruizhen Yang, Lichao Zhang, Xu Liu, Jizeng Jia, Xiuying Kong, Jiaqiang Sun
Summary: This study reveals the molecular basis of Ms2-induced male sterility in wheat, showing that Ms2 interacts with TaRomo1 and regulates the biosynthesis of ROS signals, thus affecting wheat anther development.
Article
Biochemistry & Molecular Biology
Tiemo Sven Gerber, Hagen Roland Witzel, Arndt Weinmann, Fabian Bartsch, Mario Schindeldecker, Peter R. Galle, Hauke Lang, Wilfried Roth, Dirk Andreas Ridder, Beate Katharina Straub
Summary: This study investigated the levels of 4-hydroxy-nonenal (4-HNE) in liver carcinomas and analyzed their correlation with clinical data and survival outcomes. The results showed that lower levels of 4-HNE were associated with unfavorable survival outcomes and aggressive tumor behavior in hepatocellular carcinoma (HCC). However, in intrahepatic cholangiocarcinoma (iCCA), 4-HNE levels were not correlated with prognostic parameters or survival outcomes.
Article
Pathology
Eva Tsoneva, Polina Damyanova Dimitrova, Metodi Metodiev, Velizar Shivarov, Mariela Vasileva-Slaveva, Angel Yordanov
Summary: This study examined the expression of ROMO1 in cervical cancer patients and found that its levels were significantly higher in early stage tumors compared to advanced tumors, suggesting the possible role of ROS in the progression of cervical cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Eva Tsoneva, Mariela B. Vasileva-Slaveva, Stoyan G. Kostov, Angel D. Yordanov
Summary: ROMO1, a newly discovered protein, plays a significant role in cancer cell invasion and growth by modulating the production of reactive oxygen species (ROS) through regulating mitochondrial membrane potential and permeability. Overexpression of ROMO1 is strongly associated with lymph node metastasis and a poor prognosis in cancer patients, making it a promising prognostic factor for solid malignant tumors.
Article
Biotechnology & Applied Microbiology
Qinglin Zhang, Jiadong Pan, Fangmei An, He Nie, Qiang Zhan
Summary: This study found that decreased expression of SLC39A1 is associated with clinical features and survival rates in early-stage hepatocellular carcinoma (EHCC), with patients showing lower expression having poorer prognosis. The expression level of SLC39A1 may serve as a potential diagnostic and prognostic biomarker for EHCC patients.
Article
Biochemistry & Molecular Biology
Adam Kowalewski, Damian Jaworski, Jedrzej Borowczak, Mateusz Maniewski, Krzysztof Szczerbowski, Paulina Antosik, Justyna Durslewicz, Marta Smolinska, Joanna Ligmanowska, Dariusz Grzanka, Lukasz Szylberg
Summary: Resistance to systemic therapy is a major challenge in the treatment of renal cell carcinoma (RCC). This study explores the connection between TOLLIP expression, tumor characteristics, patient survival, and resistance to therapy in RCC. The findings suggest that TOLLIP may play a role in autophagy-related signaling and contribute to the development of chemoresistance in RCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biotechnology & Applied Microbiology
Boksoon Chang, In Kyung Hwang, Seung Hyeun Lee
Summary: Elevated serum Romo1 levels were significantly associated with early recurrence in patients with lung adenocarcinoma treated with surgical resection. Combination with CEA levels could result in a higher predictive value for disease-free survival.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Lingling He, Wenjing He, Ji Luo, Minjuan Xu
Summary: Identification of key genes and the potential biomarker ENC1 in uterine corpus endometrial carcinoma (UCEC).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fangfang Zhao, Rongliang Wang, Yuyou Huang, Lingzhi Li, Liyuan Zhong, Yue Hu, Ziping Han, Junfen Fan, Ping Liu, Yangmin Zheng, Yumin Luo
Summary: This study found that plasma levels of syndecan-1 were significantly higher in AIS patients receiving rt-PA thrombolysis, and higher levels were associated with poor prognosis. Syndecan-1 may serve as a potential marker for predicting patient outcomes in this population, and adding it to conventional models could improve risk stratification.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Zhao Liu, Jiaxin Liu, Ruimiao Liu, Man Xue, Weifan Zhang, Xinhui Zhao, Jiang Zhu, Peng Xia
Summary: ZNF132 is downregulated by promoter methylation in various cancer types, including prostate cancer and esophageal squamous cell carcinoma. This study found that ZNF132 is downregulated in BC tissues and hypermethylation contributes to its downregulated expression. Furthermore, ZNF132 shows promise as a diagnostic and prognostic marker in BC.
Review
Biochemistry & Molecular Biology
Yu Jin Ahn, Hyeyoung Kim
Summary: Lutein, obtained from foods like dark green leafy vegetables and egg yolk, has antioxidant properties and can inhibit inflammatory mediators and signaling pathways, thus preventing the development of inflammatory diseases. This review discusses the anti-inflammatory function of lutein in various organs against diseases such as neurodegenerative disorders, eye diseases, diabetes, osteoporosis, cardiovascular diseases, skin diseases, liver injury, obesity, and colon diseases.
Article
Oncology
Dirk Andreas Ridder, Lana Louisa Urbansky, Hagen Roland Witzel, Mario Schindeldecker, Arndt Weinmann, Kristina Berndt, Tiemo Sven Gerber, Bruno Christian Koehler, Federico Nichetti, Annekathrin Ludt, Nadine Gehrke, Joern Markus Schattenberg, Stefan Heinrich, Wilfried Roth, Beate Katharina Straub
Summary: The role of Tak1 in hepatocellular carcinoma (HCC) development has been investigated and it has been found that high nuclear Tak1 expression is associated with poor prognosis and vascular invasion in HCC patients.
Article
Oncology
Jun Woo Bong, Jung Ae Lee, Yeonuk Ju, Jihyun Seo, Sang Hee Kang, Sun Il Lee, Byung Wook Min
Summary: Resection margin involvement after rectal cancer surgery is a negative prognostic factor, with mid-rectal cancer, pathologic stage III, mucinous/signet ring cell carcinoma, and emergency surgery patients being more frequently affected. Neoadjuvant chemoradiotherapy is a significant preventive factor for resection margin involvement. Patients with resection margin involvement show better overall survival after adjuvant treatment.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Engineering, Civil
Min-Jae Kim, Taekgeun Oh, Doo-Yeol Yoo
Summary: This study investigated the mechanical properties and microstructures of three ultra-high-performance strain-hardening cementitious composites with different mix proportions and curing conditions. The results indicate that the inclusion of ground granulated blast furnace slag (GGBS) affects the strength and ductility of the materials significantly. Wet curing conditions are more effective in enhancing the energy absorption capacity compared to air curing conditions.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2022)
Article
Engineering, Civil
Huihui Li, Lifeng Li, Doo-Yeol Yoo, Meng Ye, Cong Zhou, Xudong Shao
Summary: This paper proposed a novel non-prismatic prestressed CSW-UHPC composite box girder to enhance the cracking resistance and reduce the dead weight of highway bridges. Experimental and numerical analyses showed that the shear lag effect of the UHPC flanges in the stress concentration region was more pronounced than in the non-stress concentration region, and the boundary conditions and loading forms significantly influenced the shear lag behavior.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2023)
Article
Engineering, Civil
Meng Ye, Lifeng Li, Doo-Yeol Yoo, Lianhua Wang, Huihui Li, Xudong Shao
Summary: This study focuses on the use of ultrahigh-performance concrete (UHPC) in precast segmental beams to enhance bridge performance and durability. The shear behavior of the dry-jointed segmental beams was investigated through testing various specimens with different joint types and shear span-to-depth ratios. The results showed that shear capacity, stiffness, and cracking load of the dry-jointed segmental beams were lower than those of the monolithic specimen, and the number of shear keys also influenced the shear behavior. The study also evaluated UHPC design codes and proposed a simplified strut-and-tie model for estimating shear strength.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2023)
Article
Gastroenterology & Hepatology
Jun Woo Bong, Younghyun Na, Yeonuk Ju, Chinock Cheong, Sanghee Kang, Sun Il Lee, Byung Wook Min
Summary: This study compared the overall survival of underweight and non-underweight patients with colorectal cancer (CRC) using health insurance registry data from South Korean patients. It was found that underweight patients had worse survival rates. A nomogram to predict survival in underweight patients was constructed and found to have better predictive capability than the TNM staging system.
BMC GASTROENTEROLOGY
(2023)
Article
Engineering, Civil
Soonho Kim, Yun Sik Jang, Taekgeun Oh, Seung Kyun Lee, Doo-Yeol Yoo
Summary: With the increasing use of wireless electronic devices, electromagnetic pollution has become a serious threat. This study investigates the advantages of adding carbon fibers to strain-hardening cementitious composites (SHCCs) to enhance their mechanical and electrical properties as electromagnetic shielding materials. The results show that the addition of carbon fibers improves the tensile performance, energy absorption capacity, electrical conductivity, and EMI shielding effectiveness of the SHCCs. This study provides a basis for evaluating the EMI shielding effectiveness of damaged structures.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2023)
Article
Construction & Building Technology
Gi Woong Kim, Taekgeun Oh, Seung Kyun Lee, Seung Won Lee, Nemkumar Banthia, Eunjong Yu, Doo-Yeol Yoo
Summary: The effects of steel and polyethylene (PE) fiber hybrid reinforcement on the mechanical performance of cementless ultra-high performance alkali-activated concrete (UHP-AAC) were studied. The compressive and tensile strengths were reduced when steel fibers were replaced with PE fibers. The best performance was observed in the hybrid specimens with a medium-grade fine aggregate-to-binder (FA/B) ratio.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Rongzhen Piao, Taekgeun Oh, Gi Woong Kim, Hong-Joon Choi, Nemkumar Banthia, Doo- Yeol Yoo
Summary: This study investigates the effect of silicon dioxide nanoparticles (nano-SiO2) on the microstructure and mechanical properties of eco-friendly, cementless ultra-high-performance fiber-reinforced alkali-activated concrete (UHP-FRAAC). The results showed that the addition of nano-SiO2 improves the packing density of UHP-AAC and generates abundant C-(A-)S-H gels to increase its density. The optimal dosage of nano-SiO2 in UHP-FRAAC was suggested to be 2% by mass of silica fume.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Booki Chun, Taekgeun Oh, Hong-Joon Choi, Seung Kyun Lee, Nemkumar Banthia, Doo-Yeol Yoo
Summary: This study investigates the self-healing capacity of ultra-rapid-hardening fiber-reinforced cementitious composites. Different lengths of polyethylene (PE) fibers were incorporated with different volume fractions. The fiber reinforcing index was proportional to the tensile performance, with the length of the PE fiber being more dominant. Specimens with 2% medium-length fibers showed the most appropriate self-healing behavior.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Chemistry, Physical
Haowei Li, Jun Li, Xiaoyu Wang, Caiyue Xie, Yifei Wang, Xifeng Ding
Summary: A-type cation-deficient perovskite material has been explored as a prospective cathode for PCFCs, which can reduce polarization resistance and enhance hydration capability. This research provides an effective methodology for designing high-performance cathodes to enhance the efficiency of PCFCs.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Gastroenterology & Hepatology
Sunseok Yoon, Woong Bae Ji, Jung Sik Kim, Kwang Dae Hong, Jun Won Um, Byung-Wook Min, Sun-Il Lee, Sanghee Kang, Yeonuk Ju, Jin Kim, Jung Myun Kwak, Se Jin Baek
Summary: This study compared the oncologic outcomes of D3 and D2 lymphadenectomy in patients with clinical stage 2/3 right colon cancer, including overall survival and disease-free survival. The results showed that D3 lymphadenectomy was associated with a significantly higher 5-year disease-free survival rate compared to D2 lymphadenectomy, while there was no significant difference in overall survival between the two groups. Therefore, D3 lymphadenectomy may improve oncologic outcomes for patients with right colon cancer.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Construction & Building Technology
Joo Ha Lee, Doo-Yeol Yoo
Summary: This study aims to design a high-performance fiber-reinforced cementitious composite (HPFRCC) material for reinforcing masonry walls and assess its impact on in-plane shear performance. The study found that HPFRCC significantly enhances the shear strength and energy dissipation capacity of masonry walls.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Gi Woong Kim, Taekgeun Oh, Booki Chun, Seung Won Lee, Chung-Chan Hung, Doo-Yeol Yoo
Summary: By modifying the surface of steel fibers with an EDTA-electrolyte solution, the mechanical performance of UHP-AAC was improved, leading to higher fiber bond strength and tensile strength. The best tensile performance was achieved when straight steel fibers were surface-refined by the EDTA-electrolyte solution for 6 hours. The Weibull distribution model was used to predict crack width, and it was found that the surface treatment using EDTA solution had marginal influence on the median microcrack width of UHP-AAC, while straight and twisted fibers produced wider cracks.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Jiale Zhou, Peng Yu, Doo-Yeol Yoo, Lie Yu, Lu Ke
Summary: This study investigates the effect of different types of stirrup and cross-sectional dimensions on the torsional behaviors of ultra-high-performance fiber-reinforced concrete hollow beams. The results show that the inclusion of flanges substantially influences the torsional strength of the beams, attributed to the section torsional plastic resistance moment and UHPFRC tensile capacity in flanges.
DEVELOPMENTS IN THE BUILT ENVIRONMENT
(2023)
Article
Surgery
Kwang Dae Hong, Keehoon Hyun, Jun Won Um, Seo-Gue Yoon, Do Yeon Hwang, Jaewon Shin, Dooseok Lee, Se-Jin Baek, Sanghee Kang, Byung Wook Min, Kyu Joo Park, Seung-Bum Ryoo, Heung-Kwon Oh, Min Hyun Kim, Choon Sik Chung, Yong Geul Joh
Summary: This study investigated the surgical outcomes for recurrent rectal prolapse through a multicenter retrospective analysis, including 153 patients. The results showed no significant difference in postoperative complications and re-recurrence rate between the perineal and abdominal approaches. The perineal approach was primarily used for older and fragile patients with recurrent rectal prolapse.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2022)