Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein

GxxxG motifs hold the TIM23 complex together

(2015) Keren Demishtein-Zohary et al.   FEBS Journal

Cooperation of TOM and TIM23 Complexes during Translocation of Proteins into Mitochondria

(2015) Karin Waegemann et al.   JOURNAL OF MOLECULAR BIOLOGY

Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes

(2015) Yu Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unlocking the presequence import pathway

(2015) Christian Schulz et al.   TRENDS IN CELL BIOLOGY

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

c-di-AMP recognition byStaphylococcus aureusPstA

(2014) Martina Müller et al.   FEBS LETTERS

Architecture of the TIM23 Inner Mitochondrial Translocon and Interactions with the Matrix Import Motor

(2014) See-Yeun Ting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mgr2 Functions as Lateral Gatekeeper for Preprotein Sorting in the Mitochondrial Inner Membrane

(2014) Raffaele Ieva et al.   MOLECULAR CELL

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

Molecular Basis of the Dynamic Structure of the TIM23 Complex in the Mitochondrial Intermembrane Space

(2014) Rakhi Bajaj et al.   STRUCTURE

Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation

(2014) Christian Schulz et al.   Nature Communications

Signal recognition initiates reorganization of the presequence translocase during protein import

(2013) Oleksandr Lytovchenko et al.   EMBO JOURNAL

Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force

(2013) Ketan Malhotra et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Genetic Analysis of Complex Interactions Among Components of the Mitochondrial Import Motor and Translocon in Saccharomyces cerevisiae

(2012) B. A. Schilke et al.   GENETICS

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Mechanisms of Protein Sorting in Mitochondria

(2012) D. Stojanovski et al.   Cold Spring Harbor Perspectives in Biology

In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work

(2011) T. Shiota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into the mitochondrial protein import system

(2010) Toshiya Endo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone

(2010) Koyeli Mapa et al.   MOLECULAR CELL

Interaction of the Tim44 C-Terminal Domain with Negatively Charged Phospholipids

(2009) Milit Marom et al.   BIOCHEMISTRY

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import

(2009) Yasushi Tamura et al.   JOURNAL OF CELL BIOLOGY

Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

(2009) Dejana Mokranjac et al.   MOLECULAR BIOLOGY OF THE CELL

Thirty years of protein translocation into mitochondria: Unexpectedly complex and still puzzling

(2008) Dejana Mokranjac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fluorescence Mapping of Mitochondrial TIM23 Complex Reveals a Water-Facing, Substrate-Interacting Helix Surface

(2008) Nathan N. Alder et al.   CELL

Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria

(2008) Du\[sbreve]an Popov-Čeleketić et al.   EMBO JOURNAL

Residues of Tim44 Involved in both Association with the Translocon of the Inner Mitochondrial Membrane and Regulation of Mitochondrial Hsp70 Tethering

(2008) D. Schiller et al.   MOLECULAR AND CELLULAR BIOLOGY